Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HMGN1P18
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr21). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:121050939-121052001  UCSC
Coordinates (T2T) chr7:122366273-122367336  UCSC
Coordinates (hg19) chr7:120690993-120692055  UCSC
Strand +
Parental Sequence NM_004965.7
Parental seq. overlap 977 bp
Parental seq. overlap (%) 75.9%
Genomic Region Intragenic (CPED1)
Retrocopy Summary HMGN1P18, located on chr7:121050939-121052001, is a retrocopy of the parental gene HMGN1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HMGN1
Full Name high mobility group nucleosome binding domain 1
Also known as HMG14
Coordinate chr21:39342315-39349088
Strand -
Gene summary The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HMGN1P14
Bonobo Pan paniscus HMGN1P13
Gorilla Gorilla gorilla HMGN1P14
Orangutan Pongo abelii HMGN1P14
Gibbon Nomascus leucogenys HMGN1P23
Green monkey Chlorocebus sabaeus HMGN1P29
Crab-eating macaque Macaca fascicularis HMGN1P10
Rhesus Macaca mulatta HMGN1P9
Baboon Papio anubis HMGN1P11
Golden snub-nosed monkey Rhinopithecus roxellana HMGN1P17
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HMGN1P18
TCAAGGAAGAGCCCAAGAGGAGATTGGCGCAGTTGTCAGCTAAACCTGCTCCTGCAAAAGTGGAAGCGAAGCTGAAAAAGGCAGCAGCGAAGGATAAATCTTCAGGCAAAAATGTGCAAACAAAAGGGAAAAGGAGAGCAAAGGGAAAACAGGCCAAAGTGGCAAACCAAGAAACTAAAGAAGATTTACCTGCAGAAAACGGGGAAATGAAAACTGAGGAGAGTCCAGCCTCTGATGAAGCAGGAGAGAAAGAAACCAAGTCTGATTAATACAGTATACCATGTCTTACCAGCAGTCCCTGACTCCCCTCTTGTACAATCCAGAGGAATATTTTTACCAATTATTTTGTAAATGCAAGTTTTTTAGTAGCTCTAGAAACATTTTTAAGAAGGAGGGAATCCCACCTCCTCCCATTTTTTAAATGTAAATGCCTTTTTTTTTTTTAGAGGTAAAATCATTTGCTGGTTGTTTATTTTTTTGGCACAACCAGAAAATAGTGTGGGATATTGAATTATGGGAGGCTTTGACTGTCTCGGGTGTCAGCTTAACATTCCATAGATGGGGGTTAGTTTTTATATCCTATAAAACAAAGCATATTAAATGGAAATATGAAGTCAGTCCTGCATTTAATGTCTTGAACATTTTAAATTACTTCTATGCCCTTGCTGTTTTTTAGTAGAATTGTTTTCCAAAGAAAACCACTCCTTGATCCTGGCTTCTCCCTGTCAGAATTGTGTGCACTCTGTAAGATCTGTGGTTGTGGTAGTCCTGTTTTCCTAATAACGTTGTTATGCTGTGAAAGATTAAAAATTTGAATATGTAGTGTATATGCTATTCAGTTGTGAATTGGTGAAATGTATGTAACAGCTTATCAACATGTGAAGATATTGATAGCCCCTTAAGGAAAATTTGCTTCCAAATTTTAAGCTGGAAAGTCGCTGGAATAACTTTAAAAAAGAATTACAATACGTGGCTTTTTAGATTTTCGGTATGTATGTTAAGAATTGTGTACAAGTTTAAGTGTCTGTACTGATCCACATCCAATAAAATCTCAATTATGAAA
>NM_004965.7
ATCCGGTTCTCCCACCGCCCCCGCTGTGGGTCTCAGCAGCTCGGGCGGCGGGAGGAGTGGCAGCGGCAAGGCAGCCCAGTTTCGCGAAGGCTGTCGGCGCGCCGCGGCCCGCAGGCACCCGGCACGCGCCTTCCCCGCAGGCACCCGGCACGCGCCTTCCCCGCCGCCACGATGCCCAAGAGGAAGGTCAGCTCCGCCGAAGGCGCCGCCAAGGAAGAGCCCAAGAGGAGATCGGCGCGGTTGTCAGCTAAACCTCCTGCAAAAGTGGAAGCGAAGCCGAAAAAGGCAGCAGCGAAGGATAAATCTTCAGACAAAAAAGTGCAAACAAAAGGGAAAAGGGGAGCAAAGGGAAAACAGGCCGAAGTGGCTAACCAAGAAACTAAAGAAGACTTACCTGCGGAAAACGGGGAAACGAAGACTGAGGAGAGTCCAGCCTCTGATGAAGCAGGAGAGAAAGAAGCCAAGTCTGATTAATAACCATATACCATGTCTTATCAGTGGTCCCTGTCTCCCTTCTTGTACAATCCAGAGGAATATTTTTATCAACTATTTTGTAAATGCAAGTTTTTTAGTAGCTCTAGAAACATTTTTAAGAAGGAGGGAATCCCACCTCATCCCATTTTTTAAGTGTAAATGCTTTTTTTTAAGAGGTGAAATCATTTGCTGGTTGTTTATTTTTTGGTACAACCAGAAAATAGTGTGGGATATTGAATTATGGGAGGCTCTGACTGTCTCGGGTGTCAGCTTAACATTCCACAGATGGGGGGTTAGTTTTTATATCCTATAATACAAAGCATATTAAATGGCAATATGGAGTCAGTCCTGCATTTAATGTCTTGAACATTTTAAATTACTTCTATTACCATGTTGTTTTTTAGTAGAATTGTTTCCTAAAGAAAACCACTCTTTGATCATGGCTCTCTCTGCCAGAATTGTGTGCACTCTGTAACATCTTTGTGGTAGTCCTGTTTTCCTAATAACTTTGTTACTGTGCTGTGAAAGATTACAGATTTGAACATGTAGTGTACGTGCTGTTGAGTTGTGAACTGGTGGGCCGTATGTAACAGCTGACCAACGTGAAGATACTGGTACTTGATAGCCTCTTAAGGAAAATTTGCTTCCAAATTTTAAGCTGGAAAGTCACTGGAATAACTTTAAAAAAGAATTACAATACATGGCTTTTTAGAATTTCGTTACGTATGTTAAGATTTGTGTACAAATTGAAATGTCTGTACTGATCCTCAACCAATAAAATCTCAGTTATGAAAATA

Publications

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