Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MAXP1
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr14). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:135650940-135651454  UCSC
Coordinates (T2T) chr7:136958209-136958723  UCSC
Coordinates (hg19) chr7:135335688-135336202  UCSC
Strand +
Parental Sequence NM_002382.5
Parental seq. overlap 450 bp
Parental seq. overlap (%) 22.4%
Genomic Region Intergenic
Retrocopy Summary MAXP1, located on chr7:135650940-135651454, is a retrocopy of the parental gene MAX. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MAX
Full Name MYC associated factor X
Also known as bHLHd4
Coordinate chr14:65006101-65102541
Strand -
Gene summary The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MAXP1
Bonobo Pan paniscus MAXP1
Gorilla Gorilla gorilla MAXP1
Orangutan Pongo abelii MAXP1
Gibbon Nomascus leucogenys MAXP1
Green monkey Chlorocebus sabaeus MAXP1
Rhesus Macaca mulatta MAXP1
Baboon Papio anubis MAXP1
Golden snub-nosed monkey Rhinopithecus roxellana MAXP1
Marmoset Callithrix jacchus MAXP2
Crab-eating macaque Macaca fascicularis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MAXP1
TGCTGCAGTGGCTGCTCCCTGGGTTGTAGGAAGTGAGTGATAATGATGACGTCGGGGTGGAGAGTGACAAGCAACAACAGAGATTTCAATCTGCGGCTGACGAATGGGCCCATCATAATGCACTGGAATGAAATCGTAGGGACCACATCAAAGGCAGCCTCCAGTTTGTGGGACGCAGTCCCAACACTCCAAGGAGAGAAGGCCATAGAGTATATCCAGCATATGCGAAGGGAAAAACCACACGCCACTGAGATATTGATGACCTCAGCGGCAGAATGCTCTTCTGAAGGAGGAAGTCCGTGCACCGAAGGGGAGGTCAAGTGCCCAGCCACAGGCCAACTATCCCTCCTCAGACAGCATCCTCTACACCAATGCCAAGGGCAGCACCACCTCTGCCTTTGATGGGGGCTCCGACTGCAGCTCAGAGTTGGAGCCTGAAGAGGCCTGAAGTAGGAAGAAACTCCAGATGGAGGCCAGCTGAGTTACTCAGGGCAGGCCAGCAATAAACACTGTCT
>NM_002382.5
AGTGAGGAGGTGGTTCTTGCCCgtgttgtgtgtgtgtgtgagtgagagagcgagtgagtgagtgagtgagtgTGTGTGTGGGGGGGACTCGGCTTGTTGTTGTCGGTGACTTCcccctccccttcaccccttcccctccccgccGCCGCTGCAGTGGCCGCTCCCTGGGCCGTAGGAAATGAGCGATAACGATGACATCGAGGTGGAGAGCGACGAAGAGCAACCGAGGTTTCAATCTGCGGCTGACAAACGGGCTCATCATAATGCACTGGAACGAAAACGTAGGGACCACATCAAAGACAGCTTTCACAGTTTGCGGGACTCAGTCCCATCACTCCAAGGAGAGAAGGCATCCCGGGCCCAAATCCTAGACAAAGCCACAGAATATATCCAGTATATGCGAAGGAAAAACCACACACACCAGCAAGATATTGACGACCTCAAGCGGCAGAATGCTCTTCTGGAGCAGCAAGTCCGTGCACTGGAGAAGGCGAGGTCAAGTGCCCAACTGCAGACCAACTACCCCTCCTCAGACAACAGCCTCTACACCAACGCCAAGGGCAGCACCATCTCTGCCTTCGATGGGGGCTCGGACTCCAGCTCGGAGTCTGAGCCTGAAGAGCCCCAAAGCAGGAAGAAGCTCCGGATGGAGGCCAGCTAAGCCACTCGGGGCAGGCCAGCAATAAAAACTGTCTGTCTCCATCGTCTCATCCTCCTTTCAGTTCGTTGGTAGAGCCCTCAGAACCATTTAAGAGACTCtttatttttctctttctcccttttttttttaaatttttatttttaCGTAGAAGCTCTTGGACAACAGCTCTCGTTCTCCTTCCCCATTTCCACTGTATATTTTTTAATGTATTCCCTTCAGGGATTCCCTGTCCCCAACAGGAATTTTTAAACCAAAACACCCCAACTTGGCAGCTTTTTCTGTGGAGGACAGACGGCCGGCCGGACCTCTGAGCACATAGTGTCCTGCCCACCCTACCAGCTCCTCCAGCCCTGCCGGGCACATGCCCGGGGGACGCCTGCCCTGCCCAGGTGGCCTCCTGGCCCGCCCTCACCTCTGATAGACTTTGTGAATCTGAACTGCTCTACTTTGAGAAGATGACCGGTTTGGAGTAATCAGAATGAACCCTCCTCCTTTTTAAGGGTTTTTTTTTTTTCCTTTTTCTAAAAAGCTATGTATCGCTCCTATTGAAAGACCAGATCCTTAGAGAAGTTTGTGGTATAAAAAGGAAGTGGGGACAGATTCGCAGCACAGAGTCGCTGGCATGTTTCACTCCTGCTTCTCTCAGCCAGCTGTTTAAGCCTGCGGCGCCAGCCTCACGGAGGGCCGTGTGACACTCTCGTGGTATGTATGGGAGATGGCAGCAGTGAAGCAGCAGCCACCAGGGAGTGGCCATTTGGGGTTGGGACAGGGAGGGTGTTTTGGGTGGCATAGAGGTTTTGTATTGAGGGCCAGTGATGATGTTTTGATATTTATTTCCTGCTACTTAAATTTGAATCTGAGTGAATTGTACCTATTTCTGATGATGTCGGTCTTGCAAAGCGACAGATTCATAAAGTAATGATGAAATCTTTCTTTCTTCCCGTGTGTATTTCTAAGAAATAGAGCCAACTGATTTTGTATGTAAATACCAAGAGCAATTTACCTGGTACTAAACCCGCACCCCAGTGCGGACCCTTCCCAGCCCTCATCCCACTTCCTTTCCTACTGTCCTGGAACCTGTCTCCATTGTGTGATCCAGCCCTGGTTCTGGCTGTGGTCAGCAGATGCCAGTGAAGGGTTTTGTGTGTTTAGGCCTCATTTCTTTGTCTTTTTCCTACTCCGTTCCTGGCATTTGCTGATTTCTAGTGTATACTCTGTAGTCTCAGTTCGTGTTTGATTCCATTCCATGGAAATAAAAAGTATGTTGTACATACTGCCGAAGAATTGTCTTGCAAGTTAAGGCTTCCCCCTTTACTATAAGACTATAAATAAAAACTTATTTTATCCTT

Publications

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