Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name BRWD1P3
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr21). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:17031458-17033452  UCSC
Coordinates (T2T) chr7:17160602-17162606  UCSC
Coordinates (hg19) chr7:17071082-17073076  UCSC
Strand -
Parental Sequence NM_001007246.3
Parental seq. overlap 884 bp
Parental seq. overlap (%) 28.2%
Genomic Region Intergenic
Retrocopy Summary BRWD1P3, located on chr7:17031458-17033452, is a retrocopy of the parental gene BRWD1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name BRWD1
Full Name bromodomain and WD repeat domain containing 1
Also known as C21orf107|DCAF19|N143|WDR9|WRD9
Coordinate chr21:39184176-39321595
Strand -
Gene summary This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>BRWD1P3
TCTTAGAAGAGACTTCAGCAAGCAGCTCCAGAGTAGGGGCCATAATTCTCTATTTGTTTTGTACTAGTACCACAAGAGGATGCCTTGTAACTGCTCTTTGGTCATGATAGTGGTAGTGAATCCATTCATGTAAAATGCAATATGTCTGTTGGTTTGGGGGCACTTAAGATTCCACAGAGGTTTAGTATAATGCTCTCCCTTCTTTCTTTTTGAGTGGTGAAGAAACTAAATTTCTAGCACAGCATGACTGCTCATAGCCTGTGTTCTGTTGCTATCTGCTATGGGGGGGCACATATTGTTTTCTTAATGCATTTGCTGGTTGGTCAAGGAGGGATGGGACTTTTGAATTTGTGTCCAGACACATAGATCCTACATATGGGCTCTTCTGCGGAGGATTATCTGAGATCCTAAAATAAAAGGAAAGGTATTTAATTTTAATTTGTCACTACTTCATAAAGAGACTAAAGTATGGCAGTATTGTCCAAATTAATTTTAAAACCGAAGAAGTCAAGAATGTTCATATAAATTAAAGAAATTAAATTTTTCCTTATAAAAGTTTCCATTTTTAAGAAGTTGAATCAAACATAAGACCTTTCATCTTTAATATTGTATAGTGTAATGCTATGTTGAAAAATCAACACTTATTTGGCATTAAATGGGAAGCCCAGTGCCTGTCTTGGAGTCGGAGCTGTACTTCCTCATCAGCTGGTACCTGTTGACCAGCCTGTGTCAGAGAGTGGCCTAGGTACCAGTGCTGGAGCTGAAGCAGCACCAGTTGCTGCTGAAGAGGTTGGACTAGGAGGGCAACGAACACAACAGTCTAAAAATTTGAGACATAATTATTAGACTGAATGCAAAGAATTGGTCTTGTCCATTAAGCATGTGGCTCCTGATCACCTGCTGTGGGTCTGCCAGTGCTTCAATCTTATTTTGGTTAAAGAAATTCCACTCGGTATTTCAAGAGTCACTTCTTTCCTTGGTGCAGGAAGGCAGTCTTTGTTACATACAGCAGAACATAGGTTAATGTGGAGATGTGTTCTGCTTTGTGTTAATAGCTTTAAGCATTGTGGAGGAAAGGTGATAATATATGTAAGTCATGCTGTGAACTATACAATTCTCTGCATTTAGCATAGAACATTGAATTCTGCTGTGTGTTTCATGGGCCCTTCTGCGTTTAAAAAATTGATAAAGACACATATGTTAGCTAAAAAGCTTGAATTTATTCTGAGATGTGTTTGAAGTTTTATCACTGTGAATTCTTAATCTTCCACTTTGAAGCTCCCTCATAACTTCATTGAACGTAATTGTATGTGTCTAATAAACTCTTTAAGTGCTAGGAGTATTTCATTTGATATTTAGATTCTGAAAATCCTTTGTTATAAAGGGAAGTGATTTTATAAATTTGGAAGCAGCTTGAAAACACACACCAAAAATGTAAAATTGCATGGTTCTTTTCTTCACCAATTTAATTTTTTTGCAAAGTTATGTGCTAGCAAAATGTTTGGAATTGCTATCCTTTTTCTGTTAGCTTGGTATAAATGACTTAAACTAAGTATGTACATGTGATATGATCCATGTGTACATCTGATTAAACTGTTAATGGGCAAAGATTGTTGGTTCTTTTGATCCTAAGCATACATTAAATTACATCCCATGATTATTTTTTGTTACAAGc
>NM_001007246.3
AGGCGGCGCGCACGGTATggcggcggcggcggcggcggcggcgCGCGCCTGAGAAGAGGGGACGCCAGCCCGGTCAGGCCTCGGCGCGGCCTACAcgctccgctcgctcgctcgctcCCGCCTCCCGCCCCGCGCCCGGCCATGGCGGAGCCGTCGTCCGCCCGACGCCCGGTGCCTCTCATCGAGTCGGAGCTGTACTTCCTTATCGCCCGGTACCTATCGGCGGGCCCGTGTCGGAGAGCGGCCCAGGTGCTGGTGCAGGAGCTGGAGCAGTACCAGTTGTTGCCGAAGAGATTGGACTGGGAGGGCAACGAGCACAACAGGAGCTACGAGGAGTTGGTCTTGTCCAATAAGCATGTGGCTCCTGATCATCTTTTGCAAATCTGCCAGCGCATCGGTCCTATGTTGGATAAAGAAATTCCACCCAGTATTTCAAGAGTCACTTCTTTACTTGGTGCAGGAAGGCAGTCTTTGCTACGTACAGCAAAAGGTACCTTAATTTGAAGAAGTGTTCTGCTTTGTATTAATAGCCTAATAATTATTATAATTGTGAAGTAATGTAAGCATTGTGGAAGAAAGGTGATAATGTAACTATAAATCATGCTGTGGACTATAAAATTCTCTGCATTTAGCATAGAACATTGAATTTTATTACATAAGTGTTTAATGGGTCCTTCTGCATTAAAAAGTTGATAAAGATATAGATGTTAAGCTAAAAAGCTTGAATTTATTCTGAGATGTTGTTTGAGGTTTTATCAATGTGAGTTCTTAATTTTCCATTTTGTAGCTCACTCATAACTTCATTGAATGTAATTGTATGTGTCTAATAAACTCTTTAAATGCTAGAGGTATTTCATTTGATATTTAGCTTCTGAAAGCCCTTTGTTATAAAGGGAAGTGATTTTCTAAATTTGGTAGCAGCTTGAAAACAAGCACCACAAATGTAAAACTGCATGGTTCTTTTTTTACTAATTTAATTTTTTTGCCAAGTTATGTGCTAGCAAAATGTTTGAAATTGCTATTCTTTTTCTGTTAGCTTGGTATATATGACTTAGACTAAGTATATGTATGTGATATAAtatatgtgtacatgtggctaaactgctaatgggcaaagattgttggttcttctgatgctgagtatacatcaagttcatcccatgattattttttattacgagctattgctgatgtgatgctactcttagctgcaccaccagtataaagcttaactgagaaagaacacccctccctcttagttccgtgccagactggtttgttagctttagttgtttcttagtgctctagccatgtcaccctgtggcactaatcaggacactgtttatattcttcctcttctgtgtccctattcactttgtaattattctattttagctggttatatggtagttaattggtagcctgttttcctttgttttctttacttgtgtcaagctccatgtcgttgttttgtgatgagcagtgatttagaactggccagacCTTAGAAGAGTCTTCAGCAAGCTGCCCTAGGGTAGGGGCGTATTCTCTGTTTGTTTTGTACTGGTACCCCAGGAGGATGCCTTGTAACTGCTCTTTGGTCATGATAGTGGTAATGAATCCATTCATGTAAAATGCAATATGTCTGTTAGTTTGGGGCACCCGAGGCTCAGTAGAGGTTTAGTATGATGCCTTCCCTTTCTTCTTTGAGTTATGAAGAAACTAATTTCTGGCACAGTGTGACTGCTTCAAACCTATGTTCTGCTGCTATCTCCTATAGAGGAGGGCAGACTTTTTTTTCTTAGTGCATTTGCTGGTAGGTCAAGGAGGGATGGACTTTGAATTAGTGTTCAGAGTCACAGATCCTACGTATGTGCTCTTCAGTAGAGGATTTTCTGTGATCCTACAATGAAGGGAAAGCTATATAATTTATTGGTACTTCCTAAAGATAGAGACTAAAGTCATGGTAGTATTGGCCAAATTAATTTTAAAACTGAACAAGTCATGAATTTTCATATAAATCAAAGAACTTTTTCCTTATAAAAGCTTCCATTTTTGAAAAGTTGGATCAGTTGTAAGACCTTTCATCTTTAGTATTGTATGATATAATTCTACATTGAAAAATAAACACTTGGCATTAAATGggacttggagtcaaaagatctggttttatggtccatcttttaccaatcatttgctgtggatctctttaaaggtcctggaacctttgagcctcagttacctcacttgtaaattggcaaaaatacctacctcacagggttgttgtgaggattcaatgagctaatgtatgttgaaagcactttgtgaattgtaaagtgctacacaaatgttagttgttgttGCTGCTGTATCTGAGATGTCTTAATTTTCTTTTTCTTCAGAAATAGTCTAATAAACCTCCAGGGCTTTTCTGTTAAAGTATACTAGTTGGTAAAATGTTGAATAAACAGTTTATTACAATATA

Publications

PMID - Link Title