Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RAD23BP2
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:83663713-83666044  UCSC
Coordinates (T2T) chr7:84914167-84916499  UCSC
Coordinates (hg19) chr7:83293029-83295360  UCSC
Strand +
Parental Sequence NM_001244713.1
Parental seq. overlap 1697 bp
Parental seq. overlap (%) 43.2%
Genomic Region Intergenic
Retrocopy Summary RAD23BP2, located on chr7:83663713-83666044, is a retrocopy of the parental gene RAD23B. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RAD23B
Full Name RAD23 homolog B, nucleotide excision repair protein
Also known as HHR23B|HR23B|P58
Coordinate chr9:107283279-107332194
Strand +
Gene summary The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RAD23BP2
Bonobo Pan paniscus RAD23BP2
Gorilla Gorilla gorilla RAD23BP2
Orangutan Pongo abelii RAD23BP2
Gibbon Nomascus leucogenys RAD23BP2
Green monkey Chlorocebus sabaeus RAD23BP3
Crab-eating macaque Macaca fascicularis RAD23BP2
Rhesus Macaca mulatta RAD23BP2
Baboon Papio anubis RAD23BP2
Golden snub-nosed monkey Rhinopithecus roxellana RAD23BP2
Marmoset Callithrix jacchus RAD23BP4
Mouse lemur Microcebus murinus RAD23BP1
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RAD23BP2
GCTGTGGCTCAGTCTGCAACCCTCATCTCTGCCTTTGCTCCCACATCCACACCTATATCTATCACCCCAGCACCAACAACAGCATGTCCTGAACATGTACCTTCTAGTACAATGAAACAAGATAAACCTGCAGAAAAGTCAGCAGAAATACCAGTGGCTACTAGCTCAACATCAACTTAGAGTAGAGCAGGGGATTCTTCTCTGCCAAACCTTTTTGAAGTTGCAAGTACACTTGTAAAAGGTCAGTCCAATGAGAATATGGTAACTGAGGTCATGTCAATGGGCTATACACAAGAGCAAGCAATTGTGGCCCTGAGAGCCATTTTCAGCAATCCTGACAGAGCAGTGCAGTATCTTTTAATAGGAATACCTGGAGGTAGAAAAAATCAGGCTGTGGTTGAGCACCCCGCTCCTCCCCACCCAATCAGGTACTACTAGGACTCCTCAGTCTTCAGCAGTGTCTTCAGCTGCTGCAACTATGACAGCAACAACTACAAGTTCTGGGGAACATCCCCAAGAAATTTCACAGAATCAGTCTCAGTTTTGACAGATGAGACAAATTACTCAATAGAATCCTTCCTTGTTTTTCCAGCATTGTTATAACAGATAGGTCAAGAGAATCCTTAATTGCTGCAGCAAATTAGCCAACACCAGGAGCATTTTATTCAGATGGTAAATGAACTAGTTCAAGAAGCTGGTGAACATGGAGGAAGAGGTGGAAGTGGCAGGAGAGGAATTGCAAAGTTGGAAGTGGTCACATGAACTACATTCTAGTAACGTTAGGATAAAGAAGCTATAGAAAGGTTAAAGGCATTAAGATTTCCTGAAAGACTTATGATATGAGCATATTTTGTTTGTGAGAAGAATCAGTTTGGCTGCCAATTTTCTTCTATAGCAGAACTTGAATGAAGATTGAAAGGGACTTTTTTGTATCTTACACCTCACACCAGTGCATTACACTAACTATATCCAGTGGGTTGTCTGGAAAGACTTGGGGTCCTACCCACAATACTTTCTATATGATAGATTTTTAGGGGTGGGGAGGGTGAGATCTAGGATATAGGGCAGGGATGAATACAGTGCATGTACGCTTCAATTAGCAGGTGCTGCACATCCAAACGGTATGATTATACAGCCTGCTTTTGCAGGTCTTTATTTCTTCTACAAAGTAGGCGACTTTCCCTAGGTTTCACTCTTTTTAGTGTACTAGATTCAGAAATTTAGTGTAATGCCCTGGTTTATATTTCTTTGACTTAACATTGGTTTCAGAAAGAATCATTGGTATGTAGAATTTTCAGTCTGTTTCATGAAAACACTGGATAAGGGCTTTGTGGAATTAAAAGGAAACTCTATGGCAACTGTAAAGAGAAATGCCAAATTATTGATGGTTAAGAGAAATGCCAAATTATTGATGGTTAATTGTTGCTGCTTTACAAAAGTTTAAAATTAATGTATAAGAAATCCCATTCTTTCCTGTTAAATACATGGGGTGGGGTAGGGGAGAAAGGGAAGCTTTTCTTACAATGAAAATAACTACTTTAACTATTTTAAAATTTCTTGATAACTTAATTACAGGCCTTTTTAAAcAGATGTGCCCTTCTAACATGATCTGAGAAGCTGTATGAGTATAGACAAAGTTATTTTCCTGTTTACATTTTTTGTTTGTTTGGGGGAAAAATTGGTATGTTTCTGATTACTGTTTACTTCATTGATGTATTGCAGTAAAAGTTTTAAAACAATTGTTGCTTATTTGCTTTTGATGTATCCCTTAGTGAAATTAGCACTTTTAGGTCCAATGAAGAAATGCAGTATTCTCTCTTCCTCTTTCCCTTTCTTCAGCAGAAATGTGTTTATCAGCAAGTTGTGGGTCAAACTACTGCCTTTAAAAAAAAAAAAAACAACTCACAAAATTCTAATTCGGATCAAAATTAATGCAAACATTTCAGAACTAGATTTCTGATATTTGTAAATGATTTTCTTTATTAGTTAAGAACGTATTGCCACTGAAATAATTAGTGTTGTATTGCTTTCAAA
>NM_001244713.1
gatcaggggctttggtgttaagtagacctgagttccatttgtggttttgtaacttatttgctatgaccttgggcaaattacggttagtttcattctctgtataatagggataatacctgccttgcagagatgtgaagattagatgGTGAAAGCACTGAAAGAGAAGATTGAATCTGAAAAGGGGAAAGATGCCTTTCCAGTAGCAGGTCAAAAATTAATTTATGCAGGCAAAATCCTCAATGATGATACTGCTCTCAAAGAATATAAAATTGATGAGAAAAACTTTGTGGTGGTTATGGTGACCAAACCCAAAGCAGTGTCCACACCAGCACCAGCTACAACTCAGCAGTCAGCTCCTGCCAGCACTACAGCAGTTACTTCCTCCACCACCACAACTGTGGCTCAGGCTCCAACCCCTGTCCCTGCCTTGGCCCCCACTTCCACACCTGCATCCATCACTCCAGCATCAGCGACAGCATCTTCTGAACCTGCACCTGCTAGTGCAGCTAAACAAGAGAAGCCTGCAGAAAAGCCAGCAGAGACACCAGTGGCTACTAGCCCAACAGCAACTGACAGTACATCGGGTGATTCTTCTCGGTCAAACCTTTTTGAAGATGCAACGAGTGCACTTGTGACGGGTCAGTCTTACGAGAATATGGTAACTGAGATCATGTCAATGGGCTATGAACGAGAGCAAGTAATTGCAGCCCTGAGAGCCAGTTTCAACAACCCTGACAGAGCAGTGGAGTATCTTTTAATGGGAATCCCTGGAGATAGAGAAAGTCAGGCTGTGGTTGACCCCCCTCAAGCAGCTAGTACTGGGGCTCCTCAGTCTTCAGCAGTGGCTGCAGCTGcagcaactacgacagcaacaactacaacaacaaGTTCTGGAGGACATCCCCTTGAATTTTTACGGAATCAGCCTCAGTTTCAACAGATGAGACAAATTATTCAGCAGAATCCTTCCTTGCTTCCAGCGTTACTACAGCAGATAGGTCGAGAGAATCCTCAATTACTTCAGCAAATTAGCCAACACCAGGAGCATTTTATTCAGATGTTAAATGAACCAGTTCAAGAAGCTGGTGGTCAaggaggaggaggtggaggtggcagtggaggaATTGCAGAAGCTGGAAGTGGTCATATGAACTACATTCAAGTAACACCTCAGGAAAAAGAAGCTATAGAAAGGTTAAAGGCATTAGGATTTCCTGAAGGACTTGTGATACAAGCGTATTTTGCTTGTGAGAAGAATGAGAATTTGGCTGCCAATTTTCTTCTACAGCAGAACTTTGATGAAGATTGAAAGGGACTTTTTTATATCTCACACTTCACACCAGTGCATTACACTAACTTGTTCACTGGATTGTCTGGGATGACTTGGGCTCATATCCACAATACTTGGTATAAGGTAGTAGATTGTTGGGGGTGGGGAGGGAGGGATCTAGGATACAGGGCAGGGATAAATACAGTGCATGTCTGCTTCAATTAGCAGATGCCGCAACTCCACACAGTGTGTAAAATATATACAACCAAAAATCAGCTTTTGCAGGTCTTTATTTCTTCTGTAAAACAGTAGGTAACTTTTCCTAGGTTTCACTCTTTTTAGTGTACTAGATCCAGAAACTTAGTGTAATGCCCTGCTTTATATTTCTTTGACTTAACATTGGTTTCAGAAAGAATCTTAGCTACCTAGAATTTACAGTCTCTGTTTCATGGCAACACTGGATAATGGCTTTGTGAAATTTAAAAAATTTTTGTAGCGACTGTAAACAGAAATGCCAAATTGATGGTTAATTGTTGCTGCTTCAAAAATAAGTATAAAATTAATATGTAAGGAAGCCCATTCTTTCATGTTAAATACTTGGGGTGGGAGGGGAGAAAGGGAACCTTTTCTTAAAATGAAAATAATTACTGCTATTTTAAAATTTCTTGATCATTGAATGTGAGACCCTTCTAACATGATTTGAGAAGCTGTACAAGTATAGGCAGAGTTATTTTCCTGTTTACATTTTTTTTTTGTTTTGGGGAAAAAATTGGTAGGTGTCTAATTACTGTTTACTTCATTGTTATATTGCAGTAAAAGTTTTAAAACAACCATTGCATGTTTGCTTTTGATGTATCCCTTTGTGAAATTAGCACTTTTGGGGCCAATGGAGAAATGCAGCATTCACTCTCCCTGTCTTTTCCCCTTCCCTCAGCAGAAACGTGTTTATCAGCAAGTCGTGAGTCAAACTGCTGCCTTTTAAAAAACCCACAAAATGCTGATTCAGTTCAAAATTAATGCAAATGTTTCAAAACTGGGTTTCTGATATTTGTAAATGTGTTTCTTTATTAGATAAGAGTGTATTACCATTAAAGTCATTAGTATAATATTGCTTTCAAAAAGAAATGGTAGACAAAACTATAATCCAGCATCTTTTATTGCATTGGAAAGACTGGCAAAGTCTTTTGGATGGGTTGGGAGATGTGGCTGGAAAGTACTTTGGAAAATATACAATCAAGATATCTCATGGCATATTAAAAGAAAAATCTTAATAGCAGTGTTGGCTTTTATTTGGATTTTTTCATCTCAGTTTTTTCTGTGGAATCTCCTTCATTGGCATTGTTATTTAATCATAAACGGGGCAGATGTCTACTTGTTCAGTTTTTCAAATCTGTTTTCCTGAGTATAAATAAGAGTATTTAAAGAAATAATTTGGATTGCTTTTGTTTTTTGTTTCCTTTTTTTTAACCATCTGATACTAAGAAGATGAATTTGCACAGATTTCTCTGCATAATTTCTCAATATCTTTAGCACAGTATGGTGATGATGACTTTTAAGCATTTACATCACGTACTCATAACCTATTATGAAAATAAATGAAACTggctgggtatggtggctcatgcctataatcccagcactttgggaggccgaggtgggcagatcacttgaggccaggagattgagaccagcctgaccgtcatggcgaaaccccgtctatactaaaaatacaaaaaatagccaggcatggtggcgcacgcctgtggtcccagctacttgggaggctgaggcatgagaattgcttgaacccgggaagtgaaggttgccgtgagctgagatcacaccactgcCATAAACATGACAGGCTTTTGGACTTTGTATTACCTGTATGTTTTATAATGGATCATGCATAATTTCTCAGGAGAATAAAATGAGAATTCATATATACGTTCATCTTTCAAGTCAGAGCAATGAGTTGGGAAAAGAGGTGGCATTTCTGATCGGATAATGGAATACTCTCATTTATTTTATGACATTCTCTGTCTACTCAGATCATAGTGAAAACTGGAAACAAAAAAAAAAAACAGCCTCTTCTTGGAAAGTGACAGCAGAAGGTGGCATGGAGCTTGTGTCCTTGGACAACAAATCTGGATATACTAGGATTAATTATCAGAAGACAGCTCAGGCCAAGTTTTGATCGTTCCATACAGTACCTTGTTTATCTGCTTCTTAAAGAATCAGCCGAGACACCATAAAAGAAATAGGCTTTTTGTGCCTTTTGCTGTTAATGTTTAATTTACAAACTGTTTTGGTAAATCTCTTAATGTAAGTAGCTATTTGACTTTGGAATTTTGCATTCGAGGTATACTGTCATTTCTTGAAATCTTTTTCTCGTTTAGTTGCTCTGTGGGAAATGTGAGGAAGCCTAAGTTTGTATTTGTAAATTTCTTATGCCATCCTCTAGTCAAATTTTTTTTCATTGTTTAAAAATACGGAAGTGTTCCAATATAATTTTTTCCTGTACTGGATGGCTAGGATTCTAGAGAATTGATTATAAAATATTTTCAATACATCCAA

Publications

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