Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RNF14P3
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:98997610-98999928  UCSC
Coordinates (T2T) chr7:100230923-100233241  UCSC
Coordinates (hg19) chr7:98595233-98597551  UCSC
Strand -
Parental Sequence NM_001201365.2
Parental seq. overlap 1595 bp
Parental seq. overlap (%) 35.4%
Genomic Region Intragenic (TRRAP)
Retrocopy Summary RNF14P3, located on chr7:98997610-98999928, is a retrocopy of the parental gene RNF14. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RNF14
Full Name ring finger protein 14
Also known as ARA54|HFB30|HRIHFB2038|TRIAD2
Coordinate chr5:141966807-141990292
Strand +
Gene summary The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RNF14P3
Bonobo Pan paniscus RNF14P3
Gorilla Gorilla gorilla RNF14P3
Orangutan Pongo abelii RNF14P3
Gibbon Nomascus leucogenys RNF14P2
Green monkey Chlorocebus sabaeus RNF14P3
Crab-eating macaque Macaca fascicularis RNF14P2
Rhesus Macaca mulatta RNF14P2
Baboon Papio anubis RNF14P1
Golden snub-nosed monkey Rhinopithecus roxellana RNF14P1
Marmoset Callithrix jacchus RNF14P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RNF14P3
TATTTTCTTCCCCAAGCTTTAGGTAAGGAGAAGAGGGGTCAAGAGTTAAACTTAGAGCCCTTCTGTCTCTGGGAAGCACCCCTGTAAGACACTGTGTTGGAGCTCCCTCAGTACTACTCCCTACAACTGGGGTGGGTAGAAAAGCCTTACGGAAATTATACTGAGAGCCTGATGTACTTCATGTTACTCACATTCCTTCCAGCCTAGGTTTCTGCCAAGTCAGTCCTCTTTGGAGGGAGCCGTTTAGTCTGTAACCGACTGGATGGTGCAGCATCATTTTGATCTACTGCTTTTCAGAATATAAACTTATAATAATTAAAAAAATGTAATACCACAAACACTGTGGATCACTTGGTATTTATTAGTGGTGTATGTGGTCCACTGGTTTCAGGCCAAATCTAGAATTTAGTGATAATGACTCAGGAAGAATTTAAGTTCGATTCAATTTTCCTGGGCAGTAGAGCCTAGACTTAAGGTGACTTGTCTTTGCTACGTTTGTTCCACATTCTCTTTCTTTACCTTCTGCGTGTGGGGACATGTTGTCAGAAGACTGAGAAGCTCAGGAGGTGAGCTGCTGGCCCTGGCGAGTATTTAAGATGGAGATGAATTCGGAAAAGCAAAGCCTGTCTGAGGTGGAGAAATCAGCATCGATCGGGATTTGCCACAGAACTTCAAGTTATTTGTGAGCGGCAATTCAGATGAGTGCCCCCAGAATAGTAGCTTTGAATATACCATTTGCTTTCTCCCTCCACTTGTGCTGAACTCTGAACTGCCACCAGATTATCCATCCTCCTTCCCACCTTCATTCACACTTAGTGGCAAATTGCTGTCACCAACTCAGCTCTCTGCTCTATGCAAGCACTTAGACAACCTATGGGAAGAACACAGTGGCAGTGGGATCCTGTCTGCCTGGATGCAGTTTCTTAAGCAAGAGACCCTGGTGCACCCCAATATTGTCTCTCCCTCTGAGCTCACGATAAGTTCTCAGGAAAAAGTGCCGAGAAGGATAGCTCAAGCCCCTCCCATCAGAGCTAGATTTTGGAGGAGCTGCTGGATCTCATGTAGATCAAGAGGAAATTGTGGATGAGAGAGCTGTGCAGGATGTGGAATCACTGTCAAGTCTGATCCAGGAAATCTTGGACTTTGATCAAGCTTAGCAGATAAAATGCTTTAATAGTAGACTGTTCCTGTACGACATCTGTTTCTGCGAGAAGCTGGGCAGTGAATGCATGTACTTCTTGGAGTGAAGCCTGTGTACTGCAAAGCCTATCTGAAGGACTGCTTTGAAATCCAGATCAGAGATGGCCAGGTTCAATGCCTCAACTGCTCAGAACCAAAGTGCCCTTCGGTGGCCACTCCTGGCCAGGTCAAAGAGCCAGCGGAAGCAGAGTTCTCTGCCCGTCATGGCTGCCTTCTCCTCCCATCCACCTTGGAGCTGGTGGCAGATGTGGTGTGCTGCCCCCGCCTGTGGGGGCCTGCAGGGCCTGGCTGTACCACGGGCATCTGCTCCAGCTGTAACTTTGCCTTCTGTACCTTGTGCAGACTGACCTACCATGGGGCCTCTCCATGTAAGGTGATGGCAGAGAAATTAACAGACTTACAAAACGAATACCTGCAAGCAGATGAGGCCAAGACAAGATTTCTGTAACAGAGGTAAGGTAAGAGGGTGAGTCAGAGGGCACTGGAAGAGATGGAAAGAAAGGAGTGGCTAGAAGAGAACTCGAAGAGATGCCCATGCTGTGGAATTCACATAGAGAAGTGAGGTGGATGCCATGTACTGGCTGCAGGCTCTATTTCTATTGGGTCGGCATGGGTTCTCTCTCTAGCAACCCCTTACAAACATTTCGCCAACCCTACTTCACCGTGTTGTAACCGGCTGTTTCATGCTTGGATATGAATGGAGACATTGGGGAAGATGAGATTGAAGACTAGTTAACTACTGCTCGAGCTATGGAAGTGGATTGGTTTTCCCTAATCTTTCGTCAAGTACACAAAGTAACCTCACAGGATATTTACAGTACTATTCATTCACTCTTCCTGTGTAGAAGAGATGGAAGAACATGGCTTATATTTTCATCTGGTGAAGGAGCATTCATACTTTTTTTTAATGTAAGTTGAGAAAAAAATTCTAAGCCAAAGGTTCAGAAAATGAAGCTACAGa
>NM_001201365.2
GGGCTTCCTCACTTTTTTCCTCACGAAGAGGTCTCTGGTCTCCCCTCTCTGAGCACTCTGAGATGGCAGGATTTTCATAATATATGTAGTATGAGTTCCACATCTTGGCCTCTTACCCAGCTTCAGCAGTCTCAGCTCCACCAGTTAGAGAATAAATGGGATTTGCATGAACTCCACTCTGAGCTGAAATACAGACTGCGGTGTTAATATCCTTTTCTTCTGATTGTTATTAACAGGTCCTTATGTCGTCAGAAGATCGAGAAGCTCAGGAGGATGAATTGCTGGCCCTGGCAAGTATTTACGATGGAGATGAATTTAGAAAAGCAGAGTCTGTCCAAGGTGGAGAAACCAGGATCTATTTGGATTTGCCACAGAATTTCAAGATATTTGTGAGCGGCAATTCAAATGAGTGTCTCCAGAATAGTGGCTTTGAATACACCATTTGCTTTCTGCCTCCACTTGTGCTGAACTTTGAACTGCCACCAGATTATCCATCCTCTTCCCCACCTTCATTCACACTTAGTGGCAAATGGCTGTCACCAACTCAGCTATCTGCTCTATGCAAGCACTTAGACAACCTATGGGAAGAACACCGTGGCAGCGTGGTCCTGTTTGCCTGGATGCAATTTCTTAAGGAAGAGACCCTAGCATACTTGAATATTGTCTCTCCTTTTGAGCTCAAGATTGGTTCTCAGAAAAAAGTGCAGAGAAGGACAGCTCAAGCTTCTCCCAACACAGAGCTAGATTTTGGAGGAGCTGCTGGATCTGATGTAGACCAAGAGGAAATTGTGGATGAGAGAGCAGTGCAGGATGTGGAATCACTGTCAAATCTGATCCAGGAAATCTTGGACTTTGATCAAGCTCAGCAGATAAAATGCTTTAATAGTAAATTGTTCCTGTGCAGTATCTGTTTCTGTGAGAAGCTGGGTAGTGAATGCATGTACTTCTTGGAGTGCAGGCATGTGTACTGCAAAGCCTGTCTGAAGGACTACTTTGAAATCCAGATCAGAGATGGCCAGGTTCAATGCCTCAACTGCCCAGAACCAAAGTGCCCTTCGGTGGCCACTCCTGGTCAGGTCAAAGAGTTAGTGGAAGCAGAGTTATTTGCCCGTTATGACCGCCTTCTCCTCCAGTCCTCCTTGGACCTGATGGCAGATGTGGTGTACTGCCCCCGGCCGTGCTGCCAGCTGCCTGTGATGCAGGAACCTGGCTGCACCATGGGTATCTGCTCCAGCTGCAATTTTGCCTTCTGTACTTTGTGCAGGTTGACCTACCATGGGGTCTCCCCATGTAAGGTGACTGCAGAGAAATTAATGGACTTACGAAATGAATACCTGCAAGCGGATGAGGCTAATAAAAGACTTTTGGATCAAAGGTATGGTAAGAGAGTGATTCAGAAGGCACTGGAAGAGATGGAAAGTAAGGAGTGGCTAGAGAAGAACTCAAAGAGCTGCCCATGTTGTGGAACTCCCATAGAGAAATTAGACGGATGTAACAAGATGACATGTACTGGCTGTATGCAATATTTCTGTTGGATTTGCATGGGTTCTCTCTCTAGAGCAAACCCTTACAAACATTTCAATGACCCTGGTTCACCATGTTTTAACCGGCTGTTTTATGCTGTGGATGTTGACGACGATATTTGGGAAGATGAGGTAGAAGACTAGTTAACTACTGCTCAAGATATGGAAGTGGATTGTTTTTCCCTAATCTTCCGTCAAGTACACAAAGTAACTTTGCGGGATATTTAGGGTACTATTCATTCACTCTTCCTGCGTAGAAGATATGGAAGAACGAGGTTTATATTTTCATGTGGTACTACTGAAGAAGGTGCATTGATACATTTTTAAATGTAAGTTGAGAAAAATTTATAAGCCAAAGGTTCAGaaaattaaactacagaatattaaatattataatgtgcccaaagctctgaatagttaaaaattaaatattTATTTTCTTCCCCAAGCTTTAGGTAAGGAGAAGAGGGGTCAAGAGTTAAACTTAGAGACCCTTTGTCTCTGAGAAGCATCCTTCTAAGACATTCTGTTGGAGTTCCCTCAGTACTATTCCTTACAACTGGAGTGGGTAGAAGCCTTATGAAAATTATACTGAGAACCTGATCTCGTTTACTCCATGTTAATCACATTCCTACCAACCTAAATTTCTGCCAAGTCAGTTCTCTTTGGAGGAAGCCCATTACTCCGTAACTGACTGGATGGTCCAGTGTCATTTTGATCTGCTTTTCAGAATGGAAATTTATAATATAAATATATGTTTTAATACCACAAACACTGTGGGGCACTTGATATTTATTAGTGGTGTATATGGTCCACTGGTTTCAGGCCAAATCTAGAATTTAGTGATACTGGCTCAGAAGAATTTAAGTTCTATTCAGCCTTCCTGGGTGTTAGAACCTAGATTCAAAATGGCTTGTCTTTGCTACTTTTGTTCCACATTCTCTCTCTTTACCTTTGCCCTACCTTCTGTTTGTAAGGATGATTTTAATATTAATTCCAGGAACACATGTTTTTATTTCCTCTGCTGGAATAGGAGAAAGCTTAATATATTCCCAAGCTGAATGTTCTTGAATTATATCTGCATTTACCACTGTATATGCATATAGTGACAGTATAACCTGTCTATACTACAGTAGTTCCAGTCCTAACTTTCTGAATTATTTTTAAAGATCTTCTCTAACAAGCTATGGGAATTTGGCTTCATACTCTTTCTTTGCAACAGCAGTGTTCTGGGTGATAATTTTGAATTGATACCTGTTCCTTTTTCTGGGTTTTGTTGGCTTTTTGAAAAATTGTCTTTCCTTATCATTGGTGGGAGGCTTGGTAGCAAAGTAACATTTTTTGGAAAAGAGGACAGAAAAATTGAACTACAGCTTGAGAACGTATTCTTTTTTTCCTACTTTGTTATTGCAAATTGAGGAATCACTTTTAACTGTTTTAGGTGTGTGTGTCCAGAGTGAGCAAGGATTATGTTTTTGGATTGTCAAAGAGGATGCTTAGTCttaaaataaaaataaatttaaaaatcatcttataattagaaCAGAGTTGCTGCTATTTGTTCTGTCACCAAGGCAACTAATCACATTTTAAAACTGTTCGGCATATAACATATTCTTAAAGTAAGAAAAAAAAGGTCACAGAATAGCATCTCTTTTACCTGGGCTTGTGACTGAGCTTAGGTTTTAGGGCCCATATTTTGTTTAAACCAGATAGTTTCATGGTCTTCCATTCAGGACATTTTGTGTAAAAATTGAGGTTAATTTgctgggcacagtggctcacgcctgtaatcccagcactttgggaggcctaggcgggcggatcacgaggtcaggagttcgagaccatcatggctaacacggtgaaaccccgtctctactaaaaatacaaaaaattagctgggcatggtggcaggcgcctgtagtcccagctactcaggaggctgaggcaggagaatggcatgaacctgggaggtggagcttgcagtgagccgagatagcgccactgcactccagcctgagcgacagagcgagactccttctcaaaaaaaaaaaaaaaaaaaaTTGAGGTTAAAGAATAAATTAAAGATAAGAAATGGAAATTAAAATGATTTGTTCTACAGTATATACCTGAGAAGAGTGATTTCTGTGATCAAAGAGTTCAATTCAGATTTATTCAGAAAGAGCTACTCAGAAGCTCTATAGTTCGTGAGCTACTTGATATTTTCTAGAGATCATTTTATGTTAAGCTGTTATACATTGTTGATGATGTCATAGAAGTAGGAAAGAAGCCTTTATAATACAGTTTTATGAAAGAAATGGGAGCCTTTTTTCCCATTTATGATATTAAAAACAACACAGGTATTTGGTGTTTAGTCTCAAAAATTTGTTTGGTCACCTTAGTGATTCTTAGGTACAAAGTCTTCATCACTCAATTTTAACAAAGAAAATAGGGCTTATAAAGTTATACTTTTGAAGCATGAGTTATGAGCTAATTTTAAGATGTATAGTTTTGGTAGAGTACTTTTGTCTCAGTAAAATGAAAGATTTGGGTAACTCCCCAAATGCCCTGTAAAACAAATGGGTTTGTGGAAGGTTGTGGTGTCAGCAAAATATATGATAGAATAAAGAGTTTTGTACCTAC

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