Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PDCL3P2
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:101871594-101872559  UCSC
Coordinates (T2T) chr8:102997453-102998418  UCSC
Coordinates (hg19) chr8:102883822-102884787  UCSC
Strand -
Parental Sequence NM_024065.5
Parental seq. overlap 896 bp
Parental seq. overlap (%) 86.2%
Genomic Region Intragenic (NCALD)
Retrocopy Summary PDCL3P2, located on chr8:101871594-101872559, is a retrocopy of the parental gene PDCL3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PDCL3
Full Name phosducin like 3
Also known as HTPHLP|PHLP2A|PHLP3|VIAF|VIAF1
Coordinate chr2:100562993-100577472
Strand +
Gene summary This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PDCL3P6
Bonobo Pan paniscus PDCL3P6
Gorilla Gorilla gorilla PDCL3P6
Orangutan Pongo abelii PDCL3P4
Gibbon Nomascus leucogenys PDCL3P8
Green monkey Chlorocebus sabaeus PDCL3P4
Crab-eating macaque Macaca fascicularis PDCL3P5
Rhesus Macaca mulatta PDCL3P5
Baboon Papio anubis PDCL3P7
Golden snub-nosed monkey Rhinopithecus roxellana PDCL3P4
Marmoset Callithrix jacchus PDCL3P3
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PDCL3P2
TGGAAACAAGATGCAGGACCCCAACACAGACACTGAGTGGAATGACATCTTAGACAAGAAGGGCATCTTACCCACCAAGGAAAGTATAAAAGAATCAGAAGAGAAGGCAGAAGAGGAGCAGCACATCCTTCAGCAGTCAGTGGTGACAACATACGAAGATATGACTTTGGAAGAGCTGGAGGATCATGAAGACGAGTTTAATGAGGAGGATGAACATGCTATTGAAATGTACAGATGGCAGAGACTCGCTGAGGGGAAAGCAATTAAACTGAAGAATAAATTTGGAGAAGTTTTGGAGATTTCAGGGAAGTATTATGTTCAAGAAGTTACCAAAGCCAGTGAGGGCTTGTGGGTCATCTTGCACCTTTGCAAACGAGGAATTCCCCTCTGTGCCCTGATAAATCAGCACCTCAGTGGACTTGCCAGGAAGTTTCCTGATGTCAAATTTATCAAAGCCAATTCAACCACCTGCATACCCAATTATCCTGATAGGAATCTGCCCATGGTATTTGTTTACTTGGAAGGAGACATCAAGGCTCAGTTGATCGGTCCTCTGGTGTTTGGCGGCATGAACCTGACCAGAGATGAGTTGGGGTGGAAACTGTCTGAATCTAGAGCAGTTAAGACGGACTTGGAGGAAAACCCTAAGAAGCCGATTGAAGGTGTATTGCTGTCTTCAGTGCAGAGCTCTGTCCCCATGAGGAGGGACAGCGATTCCAAGGGTGACTGAGGCTGCAGCTGCTATCACATGCTGAACTTTCTTGTGACAAATTGTCTGGATTTCTTTAAGAAAAGGAAAAGCAAGAATGAATCCTTCTGGTTTTTAGTTTTGTATAAATTATGTTTCAAATCTTTACATTTTAGAAATAATAATTGCTGGAAATTCTGTTAAATATTTTGGAACTCTTTTTTTAAACTATAGTATTTCCTCTAAAAAAATTAAAACCAGCTATTGGTATGGCa
>NM_024065.5
GCGCGTGCACAAAAGAGAGCTGAGGGGCGGGGGCGCTGCGGCACAGCTGGTTTGAGCAACTGAACTGGAAACAAGATGCAGGACCCCAACGCAGACACTGAATGGAATGACATCTTACGCAAAAAGGGTATCTTACCCCCCAAGGAAAGTCTGAAAGAATTGGAAGAGGAGGCAGAAGAGGAGCAGCGCATCCTCCAGCAGTCAGTGGTGAAAACATATGAAGATATGACTTTGGAAGAGCTGGAGGATCATGAAGACGAGTTTAATGAGGAGGATGAACGTGCTATTGAAATGTACAGACGGCGGAGACTGGCTGAGTGGAAAGCAACTAAACTGAAGAATAAATTCGGAGAAGTTTTGGAGATCTCAGGGAAGGATTATGTTCAAGAAGTTACCAAAGCTGGCGAGGGCTTGTGGGTCATCTTGCACCTTTACAAACAAGGAATTCCCCTCTGTGCCCTGATAAATCAGCACCTCAGTGGACTTGCCAGGAAGTTTCCTGATGTCAAATTTATCAAAGCCATTTCAACAACCTGCATACCCAATTATCCTGATAGGAATCTGCCCACGATATTTGTTTACCTGGAAGGAGATATCAAGGCTCAGTTTATTGGTCCTCTGGTGTTTGGCGGCATGAACCTGACAAGAGATGAGTTGGAATGGAAACTGTCTGAATCTGGAGCAATTATGACAGACCTGGAGGAAAACCCTAAGAAGCCGATTGAAGACGTGTTGCTGTCCTCAGTGCGGCGCTCTGTCCTCATGAAGAGGGACAGCGATTCCGAGGGTGACTGAGGCTACAGCTTCTATCACATGCCGAACTTTCTTGTGACAAATTGTCTGGATTTTTTAAAAAAGGAAAAAGCAAGAATGAATCCTTGTGGTTTTTAGTTTTGTATAAATTATGTTTCAAATCTTTACATTTTGGAAATAATCATTGCTGGAGATTCTGTTAAATATTTTGGAACTCTTTTTTTTTTTAAATTATAGTATTTCCTCTAAAAAAAATTAAAACCAGCCATTTGTATGGCAAATGTC

Publications

PMID - Link Title