Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ABRAXAS1P2
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:18086832-18089890  UCSC
Coordinates (T2T) chr8:18354285-18357346  UCSC
Coordinates (hg19) chr8:17944341-17947399  UCSC
Strand -
Parental Sequence NM_139076.3
Parental seq. overlap 1658 bp
Parental seq. overlap (%) 34.8%
Genomic Region Intergenic
Retrocopy Summary ABRAXAS1P2, located on chr8:18086832-18089890, is a retrocopy of the parental gene ABRAXAS1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ABRAXAS1
Full Name abraxas 1, BRCA1 A complex subunit
Also known as ABRA1|CCDC98|FAM175A
Coordinate chr4:83459517-83485100
Strand -
Gene summary This gene encodes a protein that binds to the C-terminal repeats of breast cancer 1 (BRCA1) through a phospho-SXXF motif. The encoded protein recruits ubiquitin interaction motif containing 1 protein to BRCA1 protein and is required for DNA damage resistance, DNA repair, and cell cycle checkpoint control. Pseudogenes of this gene are found on chromosomes 3 and 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ABRAXAS1P2
Bonobo Pan paniscus ABRAXAS1P2
Gorilla Gorilla gorilla ABRAXAS1P2
Orangutan Pongo abelii ABRAXAS1P2
Gibbon Nomascus leucogenys ABRAXAS1P1
Crab-eating macaque Macaca fascicularis FAM175AP2
Golden snub-nosed monkey Rhinopithecus roxellana ABRAXAS1P2
Green monkey Chlorocebus sabaeus Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ABRAXAS1P2
ATTATTACACAACTATAACGCAACACAAACAATAATCTCTCCCCTAGTTTAGAGTCCTTTGCACGAAATTTAGCAAATCCTTAATTTTGAGTACAGTACAAGCCTGGTAATCCAGTGTGTTTGGGATAGGCTGGTGGAACTCAGAACTGATACATATATACATACATGTCTATCACATTCACTGTCTATTAGGTGTAAATCATCTTTTTATGTAAAAGACACTACTGGTTTGAGGATAGAGTTGTCTAGGAATGTTTTGTCCTGCTGTGACAGCATCACTATGCATCCCAGTGTAACATTCCTACAAAGGGAAGATCTCTTAACCAGGCATACTTACATTTGCTAGTTAGAAAACCATTCTGAGCAGTTTTAACTCCATTCAGTTGAATGGTGTACTACATTGTATGAGCTATTTGTGGACCAGATATAAATGACTATCACCCAGAACCACTTTCATTCAACATATGTAAAATGTGATGAGTGTTAACATTTTAAATAAGCGATCTGCTTAATGAACACTGATTGGTATGAAGGGGAAGTGTCATTCTTTACCTCACTCCTGAAACACTTTTCTATCCAAAGGTTGGTTTGAGTCAGTATTGGCGTCATACAACCACTTACTATAAAATAAGTTTACTGGTGGTAATGTGATGGAATTTATTCCGGATATCTGATGTTATAAACTTTAGGGTCCCTGAAATATGCAGGATCCTTGTATGTAACTGGCATAAACCCTGTAAAGAGATAATTAAAGTTCTTGACAAAGCATAATGAGCAAAATTTCAGCTAGCTCAATACAGTTGTTGAGGTGCTCTTTCTTACCCATTGTTTGAGCTCTCTTAATTGCTTTTGTGATTTGTTTCTTCCCACAAAGACCTGTAAAATAAAAAGCTTCCTTATTCATAAAAAAGTCAATATTTAAAGTTAGTATTAGAAAAGCTAGAATAGCCTTATTTTCACAATGTGGAAAGAAATTTATATGAAATTTATCTGAGTCATTAAAATTATCCTTAGGTGATAATTTTTTAGAAGTACATTACAGCTAGTGTTGCCAGATAAAATGCTGGATCTCACGCAGTACCTTTGCAAAACATGGAGTGTTCACGGCTGTTAGACACACAAGACAAACCATCTAAAACAGATACTGATAGTAGTAACCAATAAAAAAGCATCCAAAATGAGCAGCCCAGAAACAGATGAAGAGATTGAAAAGATGAAGGTTTTGGTGAATATTCACGGTCACCTACATTTTGATCCTTTTAACCTTAAAAGGAGATTTTTTTAATTTGGCTGATGGGTAAAGTCAAACATTTCCATTGTTTTTACTAGGTTGAGCTACTTGCAGTAATACAGGTAAGTTCATTTGTTTTTACTATATTCACCTCTTTGCAGTAATCCACAGATAAGTCTTAGTGCATTTATTTTACAAAGTACTTTTTCAAACATCAGATCCTTTTATTTCCAAACCTTTTTTCGCCTTTCAATAAGTTGTTGAGGGAAAGGCTTACACACATTCTTTAGAATTGGAAAAGTGATAGCATTACTGATTCCCAAATAGATGATGCTGAAGTTGTTTATACAATTGACATTCAGAAATATATTCCATGCTATCAGTTTTTTAGTTTTTATAATTCTTCAGGTGAAGTAAATAAGCAGGCACTGAGGAAAATATTATCAAATTCACAAAAAATGTGGTAGGTTGTTACAAATTCCATCGTCATTCAGATCAGATCATGACATTTAGAGAGAGGCTGCTTCACAAAAACTTGCAGGAGCATTTTTCAAACCAAGACCTGGTTTTTCTGCTATGAACACCAAGTATAATAACAGAAAGCCGCTCTACTCATCGACTGGAACATGCCTTATATAAACCTCGAAAAGGACTTTTTCACAGGGTACCTTCAGTGGTTGCCAATCTGGGCATGTCTGAACAACTAGGTTATAAAACTGTATCAGGTTCCTGTATGTCCACTGGTTTTAGCCGAGCAGTACAAACACACAGCTCTAAATTTTTTGAAGAAGATGGATCCTTAAAGGAGGTACATAAGATAAATGAAATGTATGCTTCATTGTAAGAGAAATTAAAGAGTATATGCAAAAAAGTGGAAGACAGTGAACAAGCAGTAGATAAACTAGTAAAGGATGTAAACAGATTAAAACGAGAAATTGAAAAAAGGAGATGAGCCCAGATTCCAGCAGAACGAGAGAAGAGCATCCAAAAAAGACCCTCAGGAGAACATTTTTCTTTGTCAAACATTATGGACCTTTTTTCCAGATTCTGAATTCTTCATGCATGTGTTATGTCTTTAAAAAAACAGACATGTTTCTAAAGGTAGCTCTAACAACCACCACCATCTCGATGTAGTAGACAATCTGACCTTAATGGTAGAAAACACTGACATTCCTGAAGCTAGTCCAGCTAGTACACCACAAATGGTTAAGCATAAAACCTTAGACTTAGCTGACAGATGGCAGTTCAAGAGATGAC
>NM_139076.3
CTCTTGTGTAGCCTGAGGCGGCGGTAGCATGGAGGGGGAGAGTACGTCGGCGGTGCTCTCGGGCTTTGTGCTCGGCGCACTCGCTTTCCAGCACCTCAACACGGACTCGGACACGGAAGGTTTTCTTCTTGGGGAAGTAAAAGGTGAAGCCAAGAACAGCATTACTGATTCCCAAATGGATGATGTTGAAGTTGTTTATACAATTGACATTCAGAAATATATTCCATGCTATCAGCTTTTTAGCTTTTATAATTCTTCAGGCGAAGTAAATGAGCAAGCACTGAAGAAAATATTATCAAATGTCAAAAAGAATGTGGTAGGTTGGTACAAATTCCGTCGTCATTCAGATCAGATCATGACGTTTAGAGAGAGGCTGCTTCACAAAAACTTGCAGGAGCATTTTTCAAACCAAGACCTTGTTTTTCTGCTATTAACACCAAGTATAATAACAGAAAGCTGCTCTACTCATCGACTGGAACATTCCTTATATAAACCTCAAAAAGGACTTTTTCACAGGGTACCTTTAGTGGTTGCCAATCTGGGCATGTCTGAACAACTGGGTTATAAAACTGTATCAGGTTCCTGTATGTCCACTGGTTTTAGCCGAGCAGTACAAACACACAGCTCTAAATTTTTTGAAGAAGATGGATCCTTAAAGGAGGTACATAAGATAAATGAAATGTATGCTTCATTACAAGAGGAATTAAAGAGTATATGCAAAAAAGTGGAAGACAGTGAACAAGCAGTAGATAAACTAGTAAAGGATGTAAACAGATTAAAACGAGAAATTGAGAAAAGGAGAGGAGCACAGATTCAGGCAGCAAGAGAGAAGAACATCCAAAAAGACCCTCAGGAGAACATTTTTCTTTGTCAGGCATTACGGACCTTTTTTCCAAATTCTGAATTTCTTCATTCATGTGTTATGTCTTTAAAAAATAGACATGTTTCTAAAAGTAGCTGTAACTACAACCACCATCTCGATGTAGTAGACAATCTGACCTTAATGGTAGAACACACTGACATTCCTGAAGCTAGTCCAGCTAGTACACCACAAATCATTAAGCATAAAGCCTTAGACTTAGATGACAGATGGCAATTCAAGAGATCTCGGTTGTTAGATACACAAGACAAACGATCTAAAGCAGATACTGGTAGTAGTAACCAAGATAAAGCATCCAAAATGAGCAGCCCAGAAACAGATGAAGAAATTGAAAAGATGAAGGGTTTTGGTGAATATTCACGGTCTCCTACATTTTGATCCTTTTAACCTTACAAGGAGATTTTTTTATTTGGCTGATGGGTAAAGCCAAACATTTCTATTGTTTTTACTATGTTGAGCTACTTGCAGTAAGTTCATTTGTTTTTACTATGTTCACCTGTTTGCAGTAATACACAGATAACTCTTAGTGCATTTACTTCACAAAGTACTTTTTCAAACATCAGATGCTTTTATTTCCAAACCTTTTTTTCACCTTTCACTAAGTTGTTGAGGGGAAGGCTTACACAGACACATTCTTTAGAATTGGAAAAGTGAgaccaggcacagtggctcacacctgtaatcccagcacttagggaagacaagtcaggaggattgattgaagttaggagttagagaccagcctgggcaacgtattgagaccatgtctattaaaaaataAAATGGAAAAGCAAGAATAGCCTTATTTTCAAAATATGGAAAGAAATTTATATGAAAATTTATCTGAGTCATTAAAATTCTCCTTAAGTGATACTTTTTTAGAAGTACATTATGGCTAGAGTTGCCAGATAAAATGCTGGATATCATGCAATAAATTTGCAAAACATCatctaaaatttaaatttgtcctacatttgtacttgctaaatctggcagccttaATTATTACACAACTATAACACAACACAAACAGTAATCTCTCCCCTAGTTTAGAGTCCTTTGCATGAAATTTAGCAAATCTATCATTTTGAATACAGTACAAGCCTGGTAATCCAGTGTATTTGGGATAGGCCAGTGGAACTCAGAACTGATACATATATACATGTATGTCTATCATATTCAATGTCTATTAGGTGTAAATCATCTCTTCATGTAAAAGACACTACTGGTTTGAGGGTAGACTCGTCTAGGAATATTTTGTCCTTCTGTGACAGCACCACTATCCATCCCAATGTAACATTTCTACAAAGGGAAGATATCTTAACCAGGCATACTTATATTTGCTAGTTGGAAAATCATTCTGAACAGTTTTAATTCCATTCTATTGAATGGATTATTGTATGAGCTATTTGGGGATCAGATATAAATGACAATCACACAGAACCACTTTTATTCAACATAGATAAAATGTGATGAGTGTTAACATTTTAAATAAGCAATCTGCTTAATGGACATTGGTATGAAGGGGAAGTGTCATTCTTTACCTCACTCCTCAAACACTTTTCTATCCAAAGGTTGGTTTGAGTCAGTATTGGCATCATACAACCACTTACTGTAAAATAAGTTTATTAGTGGTAACGTGATAGAATTTATTCCCGATATCTGATGTTACAAACTTTAGGGTCCTTGAGATATGCAGGATCCTTGTATGTAACTGGCATAAACCCTGTAAAGAGATAATTAAAGTTCTTGACAAAACATAATGAGCAAAATTTCAGCTAGCTCAATTCAGTTGTTGAGGTATTCTTTCTTACCCATTATTTGAGCTCTCTTAATTGCTTTTGTGATTTCTTTCTGTTTCTTCCCACAAAGACCTGTAAAATAAAAAGCTTTCTTATTCATAAAAAATGTCAATATTTAAAGTTTGCAAtttttttttttgagatggagtctccctgtgtcacccaggctggagtacagtggtgctctctcgcctcactgcaacctccgccacccaggctcaatcgattatcttgcctcagcctccttagtaactggaattacaggcatgcaccgccacacccggataatttttttgtatttgtagtagaaacggggtttcaccatattggccaggctggtcctgaactcctggcctcaggtgatctgcccacctcagcctcccaaagtgctgggattacaggtgtgagccaacatgcccagccTCAACAAGTTTTTAAGTcaaggattggtaaatcatttttgtcaagggccacaataataatctaggttttgtgggccatacagtctccatcactgccactcaactctgctgttgtagctcgaaaacaaccatatggcactacgtaaacaaaactacaaaaacaagtggggttgggtgcagtggctcacacctgtaatcccagcactttgggaggcctaggcaggtggatcacctgaggtcaggaattcaagaccagcctggccaacatggagaaacccaatctctaaaaatacaaaaattagccaggcgtggtggtgcatgcctgtaatcccagctattcgggaggctgaagcatgagaatcacttgaacccaggaggcagaggttgcagtgagccgagattgtgccacagcactccagcctgggtgacagtgagattccatctcaaaaaaaaaaaaaagtggcatttgtatatgatgaacctaatcaagataaaaagggagcaggtcgaatttggcctatgggccatagtttgctgacaccAAGTTTAAGTATCAATCTAGGAATGATTATAGTATATTCCAAAACATCAACAACAGTTTTTTAAAGCCCAGTTTTTCTATATAGTTAACTCTGCATAAGACAGCAAAATAATAATCCTCTTGGCCTAAGAGACTTTTTCATAGTAACTAGCTCTAGTCCCTGTAGTATCTGATCTAGTAGTAATTTATAGCACAATTTGAAAATTTGAGTTTTCTTAAATGATAGAAATAGATTGATATAATTCGTATCTACATTTATATTCCCATAATAAAAAAGAACATACCTGTAATGTGCCTTCCATAAATGCATCCAGTAAATGGAGAAACAAACTGGGACAAAAGCTGTTTTGGAGTTTTATGTGGAGGGGAAAAAAAAGTATCTGTTATTTATTTCTGAATGTGTAAATTTCAAAAAACAACCTTCAGGTTATATAAAGCTTTACTAAATTTCAGACACATTTCATAAAATATAAGAAAAAAATATTGTTATCCTCCTGTTACCTTTTAAATATTTTCTATCCAGTGTGTCAAGTCTATATATAATTAAACAGCAGATTAATCAGCA

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