Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PDCD10P1
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:50859668-50859994  UCSC
Coordinates (T2T) chr8:51233244-51233570  UCSC
Coordinates (hg19) chr8:51772228-51772554  UCSC
Strand +
Parental Sequence NM_145859.2
Parental seq. overlap 282 bp
Parental seq. overlap (%) 14.6%
Genomic Region Intergenic
Retrocopy Summary PDCD10P1, located on chr8:50859668-50859994, is a retrocopy of the parental gene PDCD10. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PDCD10
Full Name programmed cell death 10
Also known as CCM3|TFAR15
Coordinate chr3:167683298-167735810
Strand -
Gene summary This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PDCD10P1
Bonobo Pan paniscus PDCD10P1
Gorilla Gorilla gorilla PDCD10P1
Orangutan Pongo abelii PDCD10P1
Gibbon Nomascus leucogenys PDCD10P1
Green monkey Chlorocebus sabaeus PDCD10P2
Crab-eating macaque Macaca fascicularis PDCD10P1
Rhesus Macaca mulatta PDCD10P1
Baboon Papio anubis PDCD10P1
Golden snub-nosed monkey Rhinopithecus roxellana PDCD10P1
Horse Equus caballus PDCD10P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PDCD10P1
TTTCTTCTTATGGCAGCTGTTAATGTATAATAGTAGATAATTGAATGACTAGAGCCAGAATTCCAGGATGTAAATGAAAGTCACAAGCACTTACACAAATTCTCAGTAAGTTTCCAGTGAGCTCAATGACAGAGTGAGGATTCTGTAGACAATTAAGGATATAAAGAGTGAAATAAAAGAGCTCGATATAGTGAATAATGTCTTCAAGAAATATCAATACCAGAACTACGGGGCACTTGAACACCAAAAGAAAGTATTTTTAAAGTATTCTAAAAGTTTCAATGGTATTCTGAAAACTTATTTCAAAGATGACAAAGCAACAAATGT
>NM_145859.2
GGGTCCTTCCGGCGTCGCCGGAGTGAATTGATCCGGGAGTTGAAGAGGGCTGCAAGGTGGGAAGTGAAGTCAGTGCCTCAGTTGCTGCTTTCTCCTCTAAATCTTGGTCTCTTGTTTGGAAGTGACTAACAGCATTTTGGCATGAGAAAGCCCTAAAAAGATCAGTGTGTTTTTTGTGTCCAATTCTTTTATCACCAAAAAAGAGAAGAAATATTGCAGTGAATGAAGATTCCTCTGCATTTTAGCACTGCTTTTTCAACTGTAGTTGGCTTTTGAATGAGGATGACAATGGAAGAGATGAAGAATGAAGCTGAGACCACATCCATGGTTTCTATGCCCCTCTATGCAGTCATGTATCCTGTGTTTAATGAGCTAGAACGAGTAAATCTGTCTGCAGCCCAGACACTGAGAGCCGCTTTCATCAAGGCTGAAAAAGAAAATCCAGGTCTCACACAAGACATCATTATGAAAATTTTAGAGAAAAAAAGCGTGGAAGTTAACTTCACGGAGTCCCTTCTTCGTATGGCAGCTGATGATGTAGAAGAGTATATGATTGAACGACCAGAGCCAGAATTCCAAGACCTAAACGAAAAGGCACGAGCACTTAAACAAATTCTCAGTAAGATCCCAGATGAGATCAATGACAGAGTGAGGTTTCTGCAGACAATCAAGGATATAGCTAGTGCAATAAAAGAACTTCTTGATACAGTGAATAATGTCTTCAAGAAATATCAATACCAGAACCGCAGGGCACTTGAACACCAAAAGAAAGAATTTGTAAAGTACTCCAAAAGTTTCAGTGATACTCTGAAAACGTATTTTAAAGATGGCAAGGCAATAAATGTGTTCGTAAGTGCCAACCGACTAATTCATCAAACCAACTTAATACTTCAGACCTTCAAAACTGTGGCCTGAAAGTTGTATATGTTAAGAGATGTACTTCTCAGTGGCAGTATTGAACTGCCTTTATCTGTAAATTTTAAAGTTTGACTGTATAAATTATCAGTCCCTCCTGAAGGGATCTAATCCAGGATGTTGAATGGGATTATTGCCATCTTACACCATATTTTTGTAAAATGTAGCTTAATCATAATCTCACACTGAAGATTTTGCATCACTTTTGCTATTATCATTCTTTTAAGAATTATAAGCCAAAAGAATTTACGCCTTAATGTGTCATTATATAACATTCCTTAAAAGAATTGTAAATATTGGTGTTTGTTTCTGACATTTTAACTTGAAAGCGATATGCTGCAAGATAATGTATTTAACAATATTTGGTGGCAAATATTCAATAAATAGTTTACATCTGTTAAACATTTCTTTACTTGAAAAAATGCatatatatatgtgtgtatatatatatatatatatatatatatGAACAGAAGACCAAGACAACTTGGTGTAATGTCTAAAAAACTTCTAATGGGAGCTTATCAGCAGTTTATCAAATAATAAAGCAAGAATTTCTATTTTTGTCCTTAATCACTTTGGACACAGAGTAGTCAATGGAAATATTTTTGTTAATTACTTATAAGGTACTGAGTATTTTTATATGATTTCCAACCTGTTTTAAACGACTTATGAGTAAGAGATAGCATTTTCTAGTGTTTTTGCACTATAATGCCACTTTTTGAACTCTTGTGACAAATGTAGATTTGACTCTTAAAAATTAAGCCTTTCGTATACTGGGCCCTCATAAGCTTTGCACAATTTTTTCCCAAAAAATAGCCACAATTAATAGTAATTTGAAGCTATATCAACGGTTGGATTGAAATTGTCATGAGTGTTAATATTATATACACTCTTCAACTAGGTACAGTTTTATTTCACCATAGAGAAGTTTTAAGGAAATTATGTATCAAGTGTTCATGTTAAGTGGTTTCATTTTTCAATTATAAAATAAAGGGAAAAAATCAGAA

Publications

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