Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name NTAN1P2
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr8:86481607-86483023  UCSC
Coordinates (T2T) chr8:87601842-87603258  UCSC
Coordinates (hg19) chr8:87493836-87495252  UCSC
Strand -
Parental Sequence NM_173474.4
Parental seq. overlap 602 bp
Parental seq. overlap (%) 36.3%
Genomic Region Intragenic (RMDN1)
Retrocopy Summary NTAN1P2, located on chr8:86481607-86483023, is a retrocopy of the parental gene NTAN1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NTAN1
Full Name N-terminal asparagine amidase
Also known as PNAA|PNAD
Coordinate chr16:15037853-15056074
Strand -
Gene summary The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NTAN1P1
Bonobo Pan paniscus NTAN1P1
Gorilla Gorilla gorilla NTAN1P1
Orangutan Pongo abelii NTAN1P2
Gibbon Nomascus leucogenys NTAN1P2
Green monkey Chlorocebus sabaeus NTAN1P1
Crab-eating macaque Macaca fascicularis NTAN1P2
Rhesus Macaca mulatta NTAN1P2
Golden snub-nosed monkey Rhinopithecus roxellana NTAN1P2
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NTAN1P2
TACAGAGCCTCCTTTCAAGATCGAGGTCCAGAGGAGCAGCTGCGTGCCGCGTGAGCTTTAGCAGGAGGACCAGTGATTAGCATTTACGATGCAAAGACAGAACAACTTCGTATAGGACTGTACTCCTGGACACCATTTCCACATGTGGATTTCTGCTTGCAGCAAGATGACAAGCAAATACTAGAGAATCTTTCCACTTCGTGTCTGGCCGAGCCACCCCACTTTGTTGAACATATTAGATCTACCTTGATGTTTTTAAAAAAAAATACTGCTCCAACTAACACACTGTTTCCTGGAAATAAAGCCCTACTCTACAAAAAAAATGAAGATGGCTTGTGGGAAAAGATCTCTTCTCCAGGAAGCTAAAAAAATAGGAATTACCAAAGAAAGCAGAACCTTCTTGGCCTGACAGAGACCATTGGTGGGGCCAGCAAGAATCCAAATTTGGAACCTACATCCATTGGGTCTTAGGTCTTCTCCTTCCTTCCTCAGTGTTTTTCAAATGACTTTCAAGCCTGGGCGGCTGCCTCCACGATGCCACTGCTCATCGAGGGGCAGCGAGTGCGGCTGCCACAGTCCGCCGGGGACCTCGTCCGAGCCCACCTGCCTCTGGAGGAAACAGCCAGATGTATCAGAGGTCAGTCTGTTCAACAACTGGGACCCCAGGGCCTTCTGTATGTTCAGCAAAGAGAGCTCGCAGTGACCTCCCCAAAGGATGGCTCCGTCTCCATTTTGGGTTCTGATAATGCCACTACTTGTCACATTGGGGTCCTGTTGCACACAGGTTATGGCGCCACCTGCTTGACACATTGTGATGGAACCGACACCAAAGCTGGGGTCCCCTTGATCATGAACTCCATAAAGTCTTTTTCCGACTGCGCTCAATGTGGAAGCCTGGAAGTATACCTCGTGGGAGGCTTCAGTGATGTGGGAGGCAGTTGTCACAAAAACTCACTCATTAACTTCTTAGTGAATTTGACAGGCAAGAAGATGACATTCACTTAGTGATACTATGATTATGTGTGACAGAATTAAATGACCAGGAAGAAAACGAATAACACTTTCTAATAATATATGGCATTGCTGTCAACTTAAGACTGCAAAGATTTACAGAGCCTCCt
>NM_173474.4
GAggcgggacgcgcggcccgaggggcgggggcggcgggcggcCCGGGGCTGCAAAGCGGGGGGCCGCCGCCTCCCTGGGCCTGCCTGGGCGGCCGCCTCCGCGATGCCGCTGCTCGTCGAGGGGCGGCGAGTGCGGCTGCCGCAGTCAGCCGGGGACCTCGTCCGAGCCCACCCGCCTTTGGAGGAAAGAGCCAGACTTCTCAGAGGTCAGTCTGTTCAACAAGTGGGACCCCAGGGCCTTCTGTATGTTCAGCAAAGAGAGCTTGCAGTGACCTCCCCAAAGGATGGCTCCATCTCCATTCTGGGTTCTGATGATGCCACTACTTGTCACATTGTGGTCCTGAGGCACACAGGTAATGGGGCCACCTGCTTGACACATTGTGACGGAACCGACACCAAAGCTGAGGTCCCCTTGATCATGAACTCCATAAAATCCTTTTCTGACCACGCTCAATGTGGAAGGCTGGAAGTACACCTTGTTGGAGGCTTCAGTGACGACAGGCAGTTGTCACAAAAACTCACTCATCAACTTCTTAGTGAATTTGACAGGCAAGAAGATGACATTCACTTAGTGACATTATGTGTGACAGAATTAAATGACCGGGAAGAAAACGAAAACCACTTTCCAGTAATATATGGCATTGCTGTCAACATTAAGACTGCAGAGATTTACAGAGCATCCTTTCAAGATCGGGGTCCGGAGGAGCAGCTTCGTGCTGCGCGAACTTTAGCAGGAGGACCAATGATTAGCATTTATGATGCAGAGACAGAACAACTTCGTATAGGACCGTACTCCTGGACACCATTTCCACATGTGGATTTCTGGTTGCACCAAGATGACAAGCAAATACTAGAGAATCTTTCCACTTCGCCTCTGGCTGAGCCACCCCACTTTGTTGAACATATTAGATCTACCTTGATGTTTTTAAAAAAACACCCATCTCCAGCTCACACACTGTTTTCTGGAAATAAAGCCCTACTCTACAAAAAAAATGAAGATGGCTTGTGGGAAAAGATCTCTTCTCCAGGAAGTTAAAAAACATGAATTACCAAAGAAAGCACCTTCTTGGCCTGACAGACCATTGGTGGGGCTGGCACGAATCCAGATCTGGATCCTACATCTGTTGGGTCTTAGGCCTCCTTCCCTCCTCAGTGTCTTTCAAATGACTTTCATCAAATGACTTTCAAAATAAAACCTTATTTTGGCAAA

Publications

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