Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name GPS2P1
Plot displaying the genomic locations of a retrocopy (in chr9) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr9:2875386-2876515  UCSC
Coordinates (T2T) chr9:2879182-2880311  UCSC
Coordinates (hg19) chr9:2875386-2876515  UCSC
Strand -
Parental Sequence NM_004489.5
Parental seq. overlap 1050 bp
Parental seq. overlap (%) 88.8%
Genomic Region Intergenic
Retrocopy Summary GPS2P1, located on chr9:2875386-2876515, is a retrocopy of the parental gene GPS2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name GPS2
Full Name G protein pathway suppressor 2
Also known as AMF-1
Coordinate chr17:7312661-7315360
Strand -
Gene summary This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes GPS2P2
Bonobo Pan paniscus GPS2P2
Orangutan Pongo abelii GPS2P2
Gibbon Nomascus leucogenys GPS2P1
Green monkey Chlorocebus sabaeus GPS2P1
Crab-eating macaque Macaca fascicularis GPS2P1
Rhesus Macaca mulatta GPS2P1
Baboon Papio anubis GPS2P2
Golden snub-nosed monkey Rhinopithecus roxellana GPS2P2
Marmoset Callithrix jacchus GPS2P1
Gorilla Gorilla gorilla Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>GPS2P1
GAGAAAGCACAGAGAAGGCGGTCCCTGTTTGAGGTCTGGAGTCAGAGACAGAGCCAGACGCCCAAGGCCCGAGCGCCCACGGCAGCACCATGCCCGCAGTCTTGGAGCACCCCAAGCTTTCCAACGCCATGGCCAGAACACTGCACCAAGCACATTGTGATGGAGCAGGAGCATAAGCGACAGGAGAAAGAAGAGGTGGACAAGATGACGGAACAGAAGATGAAGGAAGAACAGGAGAGAAGGAAGAAAAAGGAGATGGAGGAGAGAATGTCACTAGAGGAGACCAAGGAACAAATTCTGAAGTTGCAGGAGAAGCTTTTGGCCCTACAGGAAGAGAAGCACCAGCTTTTCCTGCAGCTCAAGGAAGTTTTACATGAGGAAGAAAAACGGAGGCGAAAGGAACAGAGTGACCTGACCACCCTGACATCAGCTGCATACCAGCAGAGCCTGACTGTTCACACAGGTACATTACTCCTCAGCACGCAGGGGAGCCCTGGAGGACACAATCGCCCAGGCACCCTCATGGCAGCTGACAGAGCCAAACAAATGTTTGGACCCAAATTGCTTACGATCCGGCACTACGTTGGCCCAGCAACTGCTTTTGCGGAGACACCAGAGCATGGACAATTCCAAGGCAGTCCTGGTGGTGCCTATGGGACTGCTTAGCCCCCACCTCACTATAGGCACACACAGCCAGCTTATAGTCCTAGTCAGCAGCTCAGAGCTCCTTCGTCTTTCCCTGCAGTGCATTACCTATCTCAGCCACAGCCACAGCCCTGTGTCCTGCACAGCCACTTTCAGCCCACTGAGACAGATTTCCTACAGCCTGGTGGTGCCCTATCCTTGCAAAAGCAGATGGAACATGCTAACCAGCAGACTGGCCTCTCCCACCCATCCTCTTTGCGTCCCATGCACCCCCAGGCTCTGCATCCAACCCCTGGACTCCTTGCTTCCCCACAGCTCTCTGTGCAGATGCAACCAGCAGGAAAGTCGGGCTTTGCAGCTACAAGCCAACCTGGCCTTTGGCTCCCCTTCATCCAACACAGCCGGAACCTGCAATTCTACCACAAGTGACCATCAGATTATATCTTCAACACCATGCCCTTCCACCCCACCGTGGGTGAGGGTAC
>NM_004489.5
GGAGCCGCTGAGAAAGCGCAGAGAAGGCGGGCCCCGTCTGAGGTCTGGCAGTCAGAGACAGCCGGGCGCCCACGGCCCGAGCGCCCACGGCAGCACCATGCCCGCACTCCTGGAGCGCCCCAAGCTTTCCAACGCCATGGCCAGGGCGCTGCACCGGCACATTATGATggagcgggagcgcaagcggcaggaggaagaagaggtggataagatgatggaacagaagatgaaggaagaacaggagagaaggaagaaaaaggagatggaagagagaaTGTCATTAGAGGAGACCAAGGAACAAATTCTGAAGTTGGAGGAGAAGCTTTTGGCTCTACAGGAAGAGAAGCACCAGCTTTTCCTGCAGCTCAAGAAAGTTTTACATGAGGAAGAAAAACGGAGGCGAAAGGAACAGAGTGACCTGACCACCCTAACATCAGCTGCATACCAGCAGAGCCTGACTGTTCACACAGGAACTCATCTCCTCAGCATGCAGGGGAGCCCTGGAGGACACAATCGCCCAGGCACCCTCATGGCAGCTGACAGAGCCAAACAAATGTTTGGACCCCAAGTGCTTACGACCCGGCACTACGTGGGCTCAGCAGCTGCTTTTGCAGGGACACCAGAGCATGGACAATTCCAAGGCAGTCCTGGTGGTGCCTATGGGACTGCTCAGCCCCCACCTCACTATGGGCCCACACAGCCAGCTTATAGTCCTAGTCAGCAGCTCAGAGCTCCTTCGGCATTCCCTGCAGTGCAGTACCTATCTCAGCCACAGCCACAGCCCTATGCTGTGCATGGCCACTTTCAGCCCACTCAGACAGGTTTCCTCCAGCCTGGTGGTGCCCTGTCCTTGCAAAAGCAGATGGAACATGCTAACCAGCAGACTGGCTTCTCCGACTCATCCTCTCTGCGCCCCATGCACCCCCAGGCTCTGCATCCAGCCCCTGGACTCCTTGCTTCCCCCCAGCTCCCTGTGCAGATGCAGCCAGCAGGAAAGTCGGGCTTTGCAGCTACCAGCCAACCTGGCCCTCGGCTCCCCTTCATCCAACACAGCCAGAACCCGCGATTCTACCACAAGTGACCATCAGATTATATCTTCAACACCACACCCCCCACCCCATCGTGGGTGAGGGTATCCCCTGTGTGTCCCAGGCCAATAAAATCTACCTGCCACTG

Publications

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