Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PA2G4P6
Plot displaying the genomic locations of a retrocopy (in chr9) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr9:89449441-89451764  UCSC
Coordinates (T2T) chr9:101613146-101615476  UCSC
Coordinates (hg19) chr9:92064356-92066679  UCSC
Strand +
Parental Sequence NM_006191.3
Parental seq. overlap 2174 bp
Parental seq. overlap (%) 91%
Genomic Region Intragenic (SEMA4D)
Retrocopy Summary PA2G4P6, located on chr9:89449441-89451764, is a retrocopy of the parental gene PA2G4. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PA2G4
Full Name proliferation-associated 2G4
Also known as EBP1|HG4-1|p38-2G4
Coordinate chr12:56104559-56113910
Strand +
Gene summary This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PA2G4P3
Bonobo Pan paniscus PA2G4P3
Gorilla Gorilla gorilla PA2G4P3
Orangutan Pongo abelii PA2G4P4
Gibbon Nomascus leucogenys PA2G4P1
Green monkey Chlorocebus sabaeus PA2G4P2
Crab-eating macaque Macaca fascicularis PA2G4P3
Rhesus Macaca mulatta PA2G4P3
Baboon Papio anubis PA2G4P2
Golden snub-nosed monkey Rhinopithecus roxellana PA2G4P3
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PA2G4P6
GGCTTTCGCTGGCCCTCTCCTCGAGGATCGAGGGAGCTCTGACCACAGCCTGTGGCTGGGAAGGGAGGCAGAGGGGCGGCTCAGGGGAAACGAGGCTGCAGTGGTGGTGGCAGGAAGATGTCAGGCAAAGACGAGCAGCAGGAGCAAACTATCGCCGAGGACCTGGTCGTGACCAACTATAAGATGGGGGGGTGACATTGCCAATGGGGTACTTCGGTCCTTGGTGGACGCATCTAGCTCAGGTGTGTCAGTACTGAGCCTGTGTGAGAAAGGTGATGCCGTGATTATGCAAGAAACAGGGAAAATCTTCAAGAAAGAAAAAGAGATGAAGAAACGTATTGCTTTTCCCACCAGCATTTTGGTAAATAACTGTGTATGTCACTTCTCCCCTTTGAAGAGAGACCAGGATTATATTCTCAAGGAAGGTGACTTGGTAAAAATTGACCTTGGGGTCCATGTGAATGGCTTCATCACTAATGTAGCTCGTACTTTTCTGACTGATGTAGCTCAGGGGACCCAAGTAACAGGGAGGAAAGCAGATGTTATTAAGGCAGCTCACCGTTGTGCTGAAGCTGCCCCATGCCTGGTCACACCTGGAAATCAGAACACACAAGTGACAGAAGCCTGGAACAAAGTTGCCCACTTATTTAACTGCATGCCAATAGAAGGTATGCTGTCACACCAGCTGAAGCAGCATGTCATCGATGGAGAAAAAACCATTACCCAGATTCCCACAGACAAGCAGAAGAAGGACCATGAAAAAGCTGAATTTGAGGTACATGAAGTATATGCTGTGGATGTTCTCATCAGCTCAGGAAAGGGCAAGACCAAGGATGCAGGAGAGAGAACCACTATGTACAAATGAGACCCCTCCAAACAGTATGGACTGAAAATGAAAACTTGACATGCCTTCTTCAGTGACATGAAAAGGCGTTTTGATGCCATGCCATTTACTTCAAGAGCATGTGAAGATGAGAAGAAGGCTTGGATGGGTGTGGTGGAGTGCGCCAAACATGAAATGCTGCAACCATTTAATGTTCTCTATGAGAAGGAGGGTGAATTTGTTGCCCAGTTTAAATTTACAGTTCTGCTCCTGCCCAATGGCCCCATGCAGATAACCAGTGGTCCCTTCCAGCCTGACCTCTATAAGTCTGAGATGAAGGTCCAGGATGCAGAGCTAAAGACCCTCCTCCAGAGTTCTGCAAGTCGAAAAACCCAGGaGGCCTCCAAGACTGCAGAGAATGCCACCAGTGGGGAAACATTAGAAGAAAATGAAGCTGGGGACCAAGGTGGGTCCCATCTCCCCAGCTTGCTGCTCCTGCCTCATCCCCTTCCCACCACACCCTAGACTCTGTGAAGTGCAGTTCTTCTCCACCTAGGACTGCCAGCAGAGTGGGGGTGTCCCTGCCGCCACCCCAGTTTTGCAACCCACTCCCTTCCAACAACAACCAGCTCCATCTGACTCTGGTCTTGGGAGGCGAGGCTTCCCAACCACAGAAGACTTTAATTGAACAAAAGAAATTAAATAATAAAATCAGGAGTCAAAATTCATTGTCTTCAAGCCCCTCTTCCTAGCCTTTTCTTCTACTCTCTGCTTGGTCAAGGTTTGTAACCCTACGATAGAACAGGGCTAAATTAGCCACCACCACTGAAAACTCAGCCGAATTTTTTTATACCATTCTGATGTTAGCATTTTTCCATCTATTTGGGGGCTTTTTCTTCTTTTTCCATTCTCCCCAAGTATTTTATCTGGCTTCAAAATTAGGAGGATTATTTTTCAGATAGTTTTTATTCGGTGTGGCCGACTCCTCATCTGATTCAGGCTGTCAGTCAGGCCCCTCCCATTTTAGGAGCTGGAGCCTTCACTTATGAAGCAATTCCCATCTATGAAATGGATCCTCATTTGTCAATCTTTTTTCTTCCATTTTCACAAAGCTATAAAGAAATAATCCATCTCAACCTTACCCTTTTCTCTGGAGTCAATGGGGTCTTCCCTCACTCCATCTTACACAAACCTGAGCTGGAAGCTCAACTGGATTTGTTCCCTGTTTGAAATATTGTGATCTCCCTCCCTTGAAAGAAAAACGAAGAACCAGAGGAGTAGACTGACTGAAGATAAAACTCCTGGCTTTCTGAAGCTATGGATTTGGATTGGATTGCTGGGACTTTGTAGAGAAAGGTGACAAATTTCAGTACCTCCGGCATGCTGTCCCAGGAAACTAGGGCTCCCACTAACTTATGAGGTTTTTAAACACATTGAAAATGAAATGACATTAAAATAAATTTGGATTTGCTCAT
>NM_006191.3
agcccgcgcgctcgcagcttctcgctctcgcctgcctgcccgctcccttgcttgctcgcgctttcgctcgccctctcctcgAGGATCGAGGGGACTCTGACCACAGCCTGTGGCTGGGAAGGGAGACAGAGGCGGCGGCGGCTCAGGGGAAACGAGGCTGCAGTGGTGGTAGTAGGAAGATGTCGGGCGAGGACGAGCAACAGGAGCAAACTATCGCTGAGGACCTGGTCGTGACCAAGTATAAGATGGGGGGCGACATCGCCAACAGGGTACTTCGGTCCTTGGTGGAAGCATCTAGCTCAGGTGTGTCGGTACTGAGCCTGTGTGAGAAAGGTGATGCCATGATTATGGAAGAAACAGGGAAAATCTTCAAGAAAGAAAAGGAAATGAAGAAAGGTATTGCTTTTCCCACCAGCATTTCGGTAAATAACTGTGTATGTCACTTCTCCCCTTTGAAGAGCGACCAGGATTATATTCTCAAGGAAGGTGACTTGGTAAAAATTGACCTTGGGGTCCATGTGGATGGCTTCATCGCTAATGTAGCTCACACTTTTGTGGTTGATGTAGCTCAGGGGACCCAAGTAACAGGGAGGAAAGCAGATGTTATTAAGGCAGCTCACCTTTGTGCTGAAGCTGCCCTACGCCTGGTCAAACCTGGAAATCAGAACACACAAGTGACAGAAGCCTGGAACAAAGTTGCCCACTCATTTAACTGCACGCCAATAGAAGGTATGCTGTCACACCAGTTGAAGCAGCATGTCATCGATGGAGAAAAAACCATTATCCAGAATCCCACAGACCAGCAGAAGAAGGACCATGAAAAAGCTGAATTTGAGGTACATGAAGTATATGCTGTGGATGTTCTCGTCAGCTCAGGAGAGGGCAAGGCCAAGGATGCAGGACAGAGAACCACTATTTACAAACGAGACCCCTCTAAACAGTATGGACTGAAAATGAAAACTTCACGTGCCTTCTTCAGTGAGGTGGAAAGGCGTTTTGATGCCATGCCGTTTACTTTAAGAGCATTTGAAGATGAGAAGAAGGCTCGGATGGGTGTGGTGGAGTGCGCCAAACATGAACTGCTGCAACCATTTAATGTTCTCTATGAGAAGGAGGGTGAATTTGTTGCCCAGTTTAAATTTACAGTTCTGCTCATGCCCAATGGCCCCATGCGGATAACCAGTGGTCCCTTCGAGCCTGACCTCTACAAGTCTGAGATGGAGGTCCAGGATGCAGAGCTAAAGGCCCTCCTCCAGAGTTCTGCAAGTCGAAAAACCCAGAAAAAGAAAAAAAAGAAGGCCTCCAAGACTGCAGAGAATGCCACCAGTGGGGAAACATTAGAAGAAAATGAAGCTGGGGACTGAGGTGGGTCCCATCTCCCCAGCTTGCTGCTCCTGCCTCATCCCCTTCCCACCAAACCCCAGACTCTGTGAAGTGCAGTTCTTCTCCACCTAGGACCGCCAGCAGAGCGGGGGGATCTCCCTGCCCCCACCCCAGTTCCCCAACCCACTCCCTTCCAACAACAACCAGCTCCAACTGACTCTGGTCTTGGGAGGTGAGGCTTCCCAACCACGGAAGACTACTTTAAATGAAAAAAAGAAATTGAATAATAAAATCAGGAGTCAAAATTCATCGTCTTCAAGCCCCTCTTTCTAGCCTTTTCTACTACTCTCTGCTTGGTCAAGGTTTGTGCCCCACTACAGAACAGGGCTAAATTAGCCACCACCACTGAAAACTCAGCCGAATTTTTTTATACCACTCTGATGTCAGCATTTTTTCCATCTGTTTGGGGCTTTTTCCTCTTTTTTCCATTCTCCCCAAATATTTTATCTGGCTTCAAAATTAAGAGGATTATTTTTCAGATTGTTTTTATTCAGTGTGGCCGATTCCTCATCTGATTCAGGCTGTCCAGTCAGGCCCCTCCCATTTTAGGAGCTGGAGCCTTCATTTATGAAGAGATTCTCATCTATGAAATGGATCCTCATTTGTAAATCTTTTTTCTTCCATTTTCACAAAGCTGTAAAGAAATAATCCATCTCAACCTTACCCTTTTTCTCTGGAGTCAGTGGGGTCTTTCCTCGCTCCATCTTACACAGACCTGAGCTGGAAGCTCAACTGGTTTTGTTCCCTGTTTGAAATATTGTGATCTCCCTCCCATGAAAGAAAAACCAAGAACCAGAGGCGTAGACTGACTGAAGACACAACTCCTGGCTTTCTGAAGCTATGGACTTGGATTGGATTGCTGGGGGTTTGTAGAGAAAGGTGACAAATTTCAGTACCTCTGGCATGCTGTCCCAGGAAACTAGGGCTCCCACTAACTTATGAGGTTTTTAAACACATTGAAAATGACATGACATTAAAATAAATTTGGATTTGCTCATAATGA

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