Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CBLL1P1
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:121025408-121026100  UCSC
Coordinates (T2T) chrX:119325267-119325959  UCSC
Coordinates (hg19) chrX:120159262-120159954  UCSC
Strand -
Parental Sequence NM_024814.4
Parental seq. overlap 584 bp
Parental seq. overlap (%) 14.6%
Genomic Region Intergenic
Retrocopy Summary CBLL1P1, located on chrX:121025408-121026100, is a retrocopy of the parental gene CBLL1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CBLL1
Full Name Cbl proto-oncogene like 1
Also known as HAKAI|RNF188
Coordinate chr7:107743836-107764997
Strand +
Gene summary This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CBLL1P1
Bonobo Pan paniscus CBLL1P1
Gorilla Gorilla gorilla CBLL1P1
Gibbon Nomascus leucogenys CBLL1P1
Crab-eating macaque Macaca fascicularis CBLL1P1
Rhesus Macaca mulatta CBLL1P1
Golden snub-nosed monkey Rhinopithecus roxellana CBLL1P1
Marmoset Callithrix jacchus CBLL1P1
Mouse lemur Microcebus murinus CBLL1P2
Pig Sus scrofa CBLL1P2
Cow Bos taurus CBLL1P1
Sheep Ovis aries CBLL1P1
Dolphin Tursiops truncatus CBLL1P2
Panda Ailuropoda melanoleuca CBLL1P2
Cat Felis catus CBLL1P1
Greater mouse-eared bat Myotis myotis CBLL1P1
Egyptian rousette Rousettus aegyptiacus CBLL1P1
Sloth Choloepus didactylus CBLL1P3
Orangutan Pongo abelii Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Baboon Papio anubis Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CBLL1P1
GGGACGTTCAGGTAAACAACTTAGGTGAAAAAGACGATACACCAGTCCATTTATGTGACAAATGTGAATTATCAATTAAAATCTATGGACGGATGATTACATGTAAGCATGTTTTTTGCTAGGTCTGTGCTATTTTACATGGAAAAGGAAGAGATAAGATGTGTCCAGGCTGTAGCAATCCTGTGAAGCAAATTGAGAAACATACACAAGGTTTTATCTTCATGTGTAGCACACTTCAAGGGTTCAAGAGGGACCTAGAGGCTCATATCAACTACTGTCATATGAGAGTGTAAAACCCTGTTGCTTGTGCCTGACTAGAAAATGTTCATCCTCCATGATACCCCATCACGAATTGAAATCCCTAACCATTTTATGATGCGGCCAGACAAGCACCATATGAGCCAATATTCCCCCAAAGCAGCACATTATGATACCTACTTTCTTTGCAGCATTTGCCACATGAGCTACATCATTAGCCCCAAGGATATTCATGCTCCTGCAGCAGAATTGTTCACGGCTTTACCTCCATCTCCTTCAGTAAGTCAAGGAACCTTTGTATTTCAACAAGAAAACATGGCAATTTCATAACTGTTCCTATTCAAAAGCACTCCAATTCAGGTGCTTGAGAACCACACCTACTTCCTCCACATTTGCTCACCATCATCCTGAATATCAAGGTCAACGAGTAGTATT
>NM_024814.4
ACTGTGCTCTGCGAGCCGAATCATGGATCACACTGACAATGAGTTACAAGGCACTAATAGTTCTGGATCCTTGGGTGGTCTTGATGTTCGCAGACGAATTCCTATAAAGCTCATCTCCAAACAAGCAAACAAAGCGAAACCTGCACCGCGAACTCAAAGAACTATAAACAGGATGCCTGCAAAGGCTCCACCTGGTGATGAAGAAGGATTTGATTATAATGAAGAAGAACGGTATGACTGTAAAGGGGGTGAGCTGTTTGCAAATCAGCGAAGATTTCCTGGACACCTTTTTTGGGACTTTCAGATAAACATCTTAGGTGAAAAGGATGATACACCAGTTCATTTCTGTGACAAGTGTGGATTGCCTATTAAAATCTATGGGAGAATGATTCCATGCAAGCATGTTTTTTGCTATGACTGTGCTATTTTACATGAAAAAAAGGGAGATAAGATGTGTCCAGGCTGTAGTGATCCTGTGCAGCGAATTGAGCAGTGTACACGAGGTTCTCTCTTCATGTGTAGCATTGTTCAAGGGTGCAAGAGAACATATTTGTCTCAGAGAGACTTACAGGCTCATATCAACCATCGCCATATGAGAGCTGGAAAACCTGTTACCCGTGCTTCACTTGAAAATGTTCATCCTCCTATTGCCCCACCACCAACTGAAATCCCTGAGCGTTTTATAATGCCACCAGACAAGCACCATATGAGCCATATTCCGCCAAAGCAGCACATCATGATGCCACCACCTCCTTTGCAACATGTGCCACATGAGCACTATAATCAGCCACATGAGGATATTCGTGCTCCTCCAGCAGAATTGTCCATGGCTCCACCTCCACCTCGATCGGTCAGTCAGGAAACCTTTCGTATTTCAACAAGAAAACACAGCAATTTAATAACCGTCCCTATTCAGGATGACTCAAATTCAGGTGCTAGAGAACCACCACCTCCTGCCCCAGCACCTGCTCACCATCATCCTGAATATCAGGGTCAACCAGTGGTATCGCACCCTCATCATATTATGCCTCCACAGCAACATTATGcaccacccccacctcctccaccaccaATAAGCCATCCAATGCCACATCCTCCCCAGGCTGCAGGTACTCCTCACTTGGTATATAGCCAAGCTCCACCTCCACCAATGACCTCTGCTCCACCACCAATAACCCCTCCCCCTGGACATATTATTGCCCAGATGCCACCTTATATGAATCATCCTCCTCCAGGACCTCCCCCACCTCAACATGGTGGTCCACCTGTAACTGCACCCCCTCCTCACCATTATAATCCTAACTCATTACCCCAGTTCACTGAAGATCAAGGAACTCTGAGCCCTCCATTTACACAACCAGGGGGAATGAGTCCTGGTATATGGCCTGCACCAAGAGGGCCACCACCACCTCCACGATTGCAGGGTCCGCCTTCTCAAACCCCACTTCCTGGACCACATCATCCAGATCAGACAAGATATAGACCGTATTACCAATGATAATAGTATTTTGAATGGAAGATATGAGGGGGAAAAAAACTTATGTGTAGTCAATCTTTTAAGCTTTGACTGTTTTGGGAAGGAAGAGTACCTCTTATCGAGGTAGTATAAAACACATAGGGTCTTGTTTCTTAAAATGGTTTTAAATCTTGACCTTAAGATTGATTTCAAGTACCATACTGTAGTACAGATAAGTGGCTCAGTTGAGCACAGCTATATTTTAACATCTCTTTGTTCCCCTAGTTTAGTAAATTGACCCAGAGGTGACCATTTGTAAAAAATTTGAAAAAATTTTTCATTGTTTTACTTCAAAAGTATTGTTTTGTTAAACCCAACGTTTAGTTTTTCTTGTGATACATTTTGTTAACCTGTGTAAAAGGATTAAATTTCAATATGGTTGTAAAAATGCTATTTTTATGTGAATTTAAGTGCAGCCACATACTGTTTTTTAAACCATATGTTTTACCACTAATTTCCCAAAGTTATAATAAAATCCTGAAAGTAAAAATCTACTAGAATTTGCTGTAAGGCAGACTGTTAAATGATAGAGAATTATTTCACATTTTAGGCACTGAAATGTTGAGGTTTCGAGGTATAGTAAGTATACAATGCACTTCACTTGGATGCCTTTTCATTTTTAGGCAGCCTCAGGAGCACCAAAATACATTGGAATTCTAGTACTAAGATATATTTGTTCGTAATGTTAAAAGACATTACTAATTATTTGGAAAGAGATGGCCAAAATAATCAACTCTACAGGCTTCAAGCTGGTGGGGGAATGCTGTTACTCATTAATGCTTTTTTACTGAATGGTCGGAATCACATATGCACCACACATACTGATCTTAAGTAACATTATTTTATAGAACTGTTTAAATGGGTTTAAATGGTGTTCTTTAGATGAAATGTGTTCTGTTTTGTTCATTGTCTTAAACTGAATAGGGCTGAATAGGCTTTATGTAATTCTTCATTTCATGGTAGAGTTTGATGCTGTGTTTAAGTGGGTTCTTGTTTATAGGATTTTCAACTACAGTTTGAATGCCATGGAGGAATTTGAATAATATATTAATGAAGGACATATTCTTGTAATCACAAATTTGCATTTGCTCAGGTTTCATTGCTGTGTGATAGGATTTTTCCTCTAACTTGAAATTTAAAAACTTTTATTTCCTATTCCTTTTGTCGGTAAAGCAGTCTGAATTTGGAACATTTTATCATGGAGTCAACAGTGAAGACTACCAGATAATTTTGTATTGGAGAAGAGGAAATAACAGCTAAATTGTGGATTTCAGTGCTTTACATGGTGCCTTTCGAGTCAGCTTTTACATTATAGGGGCTTGTTATAGTTTAGCTAAGATGACCACTTAACAGTTTATACAGAACTCATATGTATAAATCAACATTCTTAGGATATTATTTATATCCTTTGAATAAATCCCTGTGAAGTTTTTCCTCCCCACTAAAATGGTGCATAATAAAACATGAAATATGTAGTATGCAGATATCATTTATTAGATAGTTTGTAGTGTATACATTTAGAACATACTTCTTTTGACAAAGGGTGATCTGATTGCTAATTTACCATTTTATTCTGTCAGGTACAGGTGAAACAAATTCTCATCTTGAATGATCAGATGCAAAATCATTTCTGAACCCTAGAGCAGAAGTTAGAAATAACAAAATGGCCGTTTCAACCTTGACTGGCCAAAAATAACTAATAAACTTTTTTGTTTTAAGTCAGGCAAGTGATTTTCTACATTTAGCAGTTTGAAAGTCCAGTGTTAATGCAATATTTCTAGTGAGAAATGCTTGTTATTAAAAGCATGGGAGTGATAGTGTGAAATGGTGGTGAGTGCTTCTATCATATTACTGTAGGTACTTGGACTGGTGCAAACTTGATTCCTTTTCATCCCCCTGTTTAGGAGCTATTAAAATATTACTGTTAAAAATCCAAACCATTCTTTGTTCCATGTAATAAGAAAATAGCCAAAATCACTTTAGAGCTTCTCAACTATTTATGAAGAGCTATCCTGCTTTTATTGAAAGTCACTAGAGTTGAATGTGGTAAGAAACCACTTAGCCTATGTATTGGACGAGAAAATCAGTATCATGATAAAATTTTGAATTAAGAGAACCCTTGTAGAGTTTTTAAAAAATGATTTATTTTCAATTAGGTTTAAGAAATCTATGTTATGCAGGGAGGCATATCAGATGAATGTTGTAGCAGACAAAAGTTTTAAATCGTGTTAGACTTGAATTCATCAATTGTTTGAATGAGGGTGGGTGGGTAGAAGGATAACAAAATTACTGTTAGTGTTTCTTTCCTTACGGAAAAAGATGTGAATCCCAGCCTTATTTCAGGGAAGCCTTTGAAGCTATGATGGACATAAGTCTAAATTAAATGTATGTATGTTTCATTATATTGCTCTTAAGACTACTGAGGTGGCAGTTTAATTCTTAAAAACAATAAAATGGAAGCATAAATACTA

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