Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CBX1P2
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:17098392-17100319  UCSC
Coordinates (T2T) chrX:16681015-16682944  UCSC
Coordinates (hg19) chrX:17116515-17118442  UCSC
Strand -
Parental Sequence NM_001127228.2
Parental seq. overlap 1671 bp
Parental seq. overlap (%) 73.1%
Genomic Region Intragenic (REPS2)
Retrocopy Summary CBX1P2, located on chrX:17098392-17100319, is a retrocopy of the parental gene CBX1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CBX1
Full Name chromobox 1
Also known as CBX|HP1-BETA|HP1Hs-beta|HP1Hsbeta|M31|MOD1|p25beta
Coordinate chr17:48070059-48101478
Strand -
Gene summary This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CBX1P4
Bonobo Pan paniscus CBX1P4
Gorilla Gorilla gorilla CBX1P3
Orangutan Pongo abelii CBX1P4
Gibbon Nomascus leucogenys CBX1P3
Green monkey Chlorocebus sabaeus CBX1P5
Crab-eating macaque Macaca fascicularis CBX1P5
Rhesus Macaca mulatta CBX1P5
Golden snub-nosed monkey Rhinopithecus roxellana CBX1P2
Marmoset Callithrix jacchus CBX1P8
Baboon Papio anubis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CBX1P2
AAACCATTTTTTAACAAATCCTAAGAAGTAACTGATACCCAAAATGCTCTGTCTTGAGTCATGAGATCCATCAGTTCTTGATATTATCTAGACTTGGATCTAGAGCTACATTGTAAAATCTTTTTAGGCATGTGTTAGATTTCTTTGAAAACTTTGTTTGAATGTAAACTTCACACCACACTCTCAGTTTTTGTCTTAATAAAACTATAGATATATAATCTATGGAGAAAAAACAAAACAAGAAGAAAGTGGAGGAGGTGCTAGAAGAGGAGGAACAGGAATATGTGGTGGAAAAAGTTCTCTACCGTCGATTGGTAAAGGGCAAAGTGGAGTACCTCCTAAAGTGGAAGGGATTCTCAGATGAGGACAACACATGGGAGTCAGAAGAGAACTTGGATTGCCCTGACCTCATGAGTTTCTGCCGTCACAGAAAACAGCACATGAGATAGACAAATCAGAGGGAGGCAAGCACAAAGCTGATTCTGATTCTGAAGATAAGGGAGAGGAGAGCAAACCAAAGAAGAAGAAAGAAGAGTCAGAAAAGCCACGAGGCTTTGCTCAGGGTTTGGAGCCGGAGCAGATTATTGGAGCTACAGACTCCAGTGGAGAGCTCATGTTCCTGATGAAAGGGAAAAATTCTGATGAGGCTGACCTCGTCCCTGCCAAGGAAGTCAATGTCAAATGCCCACGGGTTGTCATATCCTTCTATGAGGAAAGGCTGACGTGGCATTCCTACCCCAAAGAGGATGATGACAAGAATTAACTCTCCTGAGTACCAGCCTCTATCACATCTGACTGTGGGTTTCAGGTGGGAAGGAAAGAAGTTCTACTTGTCTTGACACCATAGAGGTAGCTTGAGAAGATGCCCTTTGAAGAGCCAGTATCGTTTCTGTGCCCTGCAGCAGCCCAAGTGTTTTAAAGCCATTCCAAGCTGTATAGTTTGCACACCCGTCCCAGTGGAGGGGAAGGGGGATAAGTGCTTCAAGGCAACCTTTTCTGCACTTTGCTGAGAAAAAGCAAAGGGCCCTTTATGAAGGACAAAACTTGCAGAACTGGGTGTGTGGGAGAGCAAAAAAATACTGTAGATAATCAAAGAGCATCTCCGCAACGCACAACTTTCTTCCCAATAGTGTTAACTCTACATTTTTACAGCGTAGCAAATGTGTAGTTTTTGGCTATTACTGGTGTATTATGTGGGAGAGGGAGGAATGGGGAGGGTGGAAAGGGAGATGGGTAGCATCATTTTGATTAAAATTTGGGGCCTGATAGGGGACATGGTGAAGCAATGCAAAGAACAGAAAACTAATGATTTGCTTCTATGTCCAGAATATTTTACCTTTGAAAAAAATGTCACTGGCACCATAAATACGGACTGTGAGAGACTTTAAAAGCTGTGAATGTCTGAAATCTATAAGCCATGGTGTTCCCTGCCTAAACTTAATGTACTTAGTCTCACAAAGGACTAAGCCAGTTAATAAGTTACCAGAGTTGCCATTTTGGAGATGGAAATTGACTGAGGAAGGAAGGTCTTTTATTGGAGAGTATACAGTACAAGCAGATCATTCTGCCTCAGAGGTGCTAATTCCTGAAATTAGAAGACCCTTTCTTTTCCAATAATAAAGTTATAAATATCAGCTTGTTCATCCTAGCCACTGGCTGAGGTGTTGGGGAAGGGAAAGAGGGTGGTAGAGGAGATAAGACAGGAGGGAAGTAAAGGGCCCATGCTCTTAGTTGGGACAACTTTTGGAGCCATTCTCTTTTGAGCTTTGAACTCTGAAACCATTGGTGGCAGAGTTCAGTCACTGACAGCACAAGTTTCACTGAATTGACTCAAGAGTTGAGTGATTTCAAAAGCCTTGGTCTCAGGAGATTAAACTTTCATACTGGGCAGTGGTTCACTTTAAAa
>NM_001127228.2
GCGAGCGGCGGGCAGCGCAGACTGCGAGGCTCTTTTGTTCGGCTGAGGGGAGGGCCGTTGGCCGGGGCCTGCGGTACGCCGCTTCAGTGAGGGACGCCACTGCGGCCACCCGGCTTGCTGCCTTCCTGGGCGCCACTCCCCCAGGCGACCCGACGCGACGCGCCAGCAGCGCAGCACCGATTCCTCTCGGGCTCTTGGGCGCTGCTCTGAGCAGCGTCACCCTTTACACCAGAAAGCTGGCGGGCACTATGGGGAAAAAACAAAACAAGAAGAAAGTGGAGGAGGTGCTAGAAGAGGAGGAAGAGGAATATGTGGTGGAAAAAGTTCTCGACCGTCGAGTGGTAAAGGGCAAAGTGGAGTACCTCCTAAAGTGGAAGGGATTCTCAGATGAGGACAACACATGGGAGCCAGAAGAGAACCTGGATTGCCCCGACCTCATTGCTGAGTTTCTGCAGTCACAGAAAACAGCACATGAGACAGATAAATCAGAGGGAGGCAAGCGCAAAGCTGATTCTGATTCTGAAGATAAGGGAGAGGAGAGCAAACCAaagaagaagaaagaagagTCAGAAAAGCCACGAGGCTTTGCTCGAGGTTTGGAGCCGGAGCGGATTATTGGAGCTACAGACTCCAGTGGAGAGCTCATGTTCCTGATGAAATGGAAAAACTCTGATGAGGCTGACCTGGTCCCTGCCAAGGAAGCCAATGTCAAGTGCCCACAGGTTGTCATATCCTTCTATGAGGAAAGGCTGACGTGGCATTCCTACCCCTCGGAGGATGATGACAAAAAAGATGACAAGAACTAACGCTCCTGAGTACCAGCCCCTGTCACATCTGACTGTGGGTTTCAAGTGGGAAGGGAAGGAGTTCTACTTGTCTTGACACCATAGAGGTGGCTTGAGAAGATGTCCTTTGAAGAGCCAGTATAGTTTCTGTGCCCTGCAGCAGCCCAAGTGCTTTAAAGCCGTTTCAAGCTGTATAGTTTGCACACCCATCCCAGTGGAGGGGAAAGGGGATAAGTGTTTCAAGGCAACCTTTTCTGCACTTTGCTGCGAAAAGCAAAGGGCCTTCTATGAAGGACAAAACTTGCAGAATTGGGTGTGTGGGAGAGCAAAAAAATACTGTAGATCTTCAAAGAGCATCTCCACAACCCACAGCCTTCTTCCCAATAGTGTTAACTCTGCATTTTTACAGCGTAGCATGTGTGTAGTTTTTGGCTATTACTGGTGTATTATTTGggggagggagggatggggaggggagaaagggagATGGGTAGCATCATTTTGATTAACATTTGGGGCCTGATAGGGGAAATGGTGAAGCAATGGAAAAGAACAGACAACTAATGATTTGCTTCTATGTCCAGAATATTTTACCTTTAAAAAAATGTCATTGGCACCATAAATAAGGACTGTGAGAGACTGTTTAAAAGCTGTGAAAGTCTGAAACCTATAAGCCAAGGTGTTCCCTGCCTAAACTTATTGCTGTTCCCACAAAGGACTAAGCCTGTTCATAAGTTACCAAAGTTGCCATTTTGGAGATGGAAATTGACGAGGAGGGAAGGTCTTTTATTGGAGAGTATACAGTACAAGCAGATCATTCTGCCTTAGAGGTGCTAATTCCCGAAATTAGAAGACCCTTTCTTTTCCAGTAACGAAGTTATAAATATCAGCTTGTTCATCCAAGCCACTGGCTGAGGTGTTAGGAAGAGGAAGAGGGTGGTAGAGGAGGTAAGACAGTAGGGAAAGACAAGGGCCCATGCTCTTAGTGGGGAAAACTCTTGGAGCCGTTTACTTTGAGCTTTGAACACTGAAACCATTGTTGGCAGGGTTCAGTCACTGACAGCACAAGTTTCACTGAATTGATCCAAGAGTTTAGTGATTTCAAAAGCCTTGGTCTCAGGAGAAGATTAAACTTTCATATTGGGCAGTGGTTCACTTTAAAacacacacatacacacacaAAACAATTTTTTAAGAAATCCTAATAAGTAACATACCCAAAATGCTCTGTCTTGAGTCATGAGAACCATCAGTTCTTGATATTGTCTAGACTTGCATCTAGAGCTACGTTGTAAAATTCTTTTAGGCATGTGTTAGATTTCTGTGTAAACTTTGTTTAAATGTAAACTTCATACTACATTGTCAGTTTTTGTCTTAATAAAACTATAGATTTATAA

Publications

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