Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SNRPEP9
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:24513403-24513705  UCSC
Coordinates (T2T) chrX:24097734-24098036  UCSC
Coordinates (hg19) chrX:24531520-24531822  UCSC
Strand +
Parental Sequence NM_003094.4
Parental seq. overlap 260 bp
Parental seq. overlap (%) 16.6%
Genomic Region Intragenic (PDK3)
Retrocopy Summary SNRPEP9, located on chrX:24513403-24513705, is a retrocopy of the parental gene SNRPE. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SNRPE
Full Name small nuclear ribonucleoprotein polypeptide E
Also known as HYPT11|SME|Sm-E|snRNP-E
Coordinate chr1:203861599-203871152
Strand +
Gene summary The protein encoded by this gene is a core component of U small nuclear ribonucleoproteins, which are key components of the pre-mRNA processing spliceosome. The encoded protein plays a role in the 3' end processing of histone transcripts. This protein is one of the targets in the autoimmune disease systemic lupus erythematosus, and mutations in this gene have been associated with hypotrichosis. Several pseudogenes of this gene have been identified. [provided by RefSeq, Jun 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SNRPEP12
Bonobo Pan paniscus SNRPEP13
Gorilla Gorilla gorilla SNRPEP12
Orangutan Pongo abelii SNRPEP11
Gibbon Nomascus leucogenys SNRPEP11
Green monkey Chlorocebus sabaeus SNRPEP10
Crab-eating macaque Macaca fascicularis SNRPEP10
Rhesus Macaca mulatta SNRPEP10
Baboon Papio anubis SNRPEP11
Golden snub-nosed monkey Rhinopithecus roxellana SNRPEP3
Marmoset Callithrix jacchus SNRPEP14
Mouse lemur Microcebus murinus SNRPEP9
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SNRPEP9
TACCATGGTGCACTGTGGCCAGGGCCAAAAAGTGCAGAAGGTGAATATAGCCCATCAACCTTACCTTCATCTTCAGATACTTGCAAAATAGATCTCGGATTCAGGTATGGCTCTATGAGCAAGTGAATATGCTGATAGAGGGCCGTGTCATTGGTTTTGACGAGTCTGTGAACCTCATATCAGATGATGCAGAAGCGATTCATTGTGAAACAAAGCCAAGAAAACCCCTGGGCCAGATCGTGCTAAAGGAGATCATATTCTGCCACAAAATGTCTCTAACCAGAAATGATCAAGGAAGTGAGA
>NM_003094.4
CTTTATTCCGGAAGTTGCTCTCAGAGGCAGCGTGCGGGTGTGCTCTTTGTGAAATTCCACCATGGCGTACCGTGGCCAGGGTCAGAAAGTGCAGAAGGTTATGGTGCAGCCCATCAACCTCATCTTCAGATACTTACAAAATAGATCGCGGATTCAGGTGTGGCTCTATGAGCAAGTGAATATGCGGATAGAAGGCTGTATCATTGGTTTTGATGAGTATATGAACCTTGTATTAGATGATGCAGAAGAGATTCATTCTAAAACAAAGTCAAGAAAACAACTGGGTCGGATCATGCTAAAAGGAGATAATATTACTCTGCTACAAAGTGTCTCCAACTAGAAATGATCAATGAAGTGAGAAATTGTTGAGAAGGATACAGTTTGTTTTTAGATGTCCTTTGTCCAATGTGAACATTTATTCATATTGTTTTGATTACCCTCGTGTTACTACAAGATGGCAATAAATACTATGGGATTGTTTGTATTAAAAAATTTACATTGCTTCTTACTATTCAGCAGTAGAAACTTTTTACACAGTAACACCATTCGTTGCTGGTATTTAGTTTTCTGAAGGGTCGCAGTTGCCTTGAGCACTTGGTATTCGCAGAGCTTGGACCTGTAGATTTTGAGGCAGATTAGGAATTCTGCCTGATGGGTAAGCTTCCAGTATTGGGAGGTGGAGAAGGGGAGGGTTCAGAAAAATAAATAAGAGTTATTGCACTAACAAAAGTCTTCATCACTTGTAGTTCTGGATGCTGGAATACCAGAGTTTCTAACCTAAATATGTTGGGTACATTATTTAATGGGGTCAGTATTGCTCAACACTCTCATTGAGTCACTGTGAGGTCTTTGTGAATTTTATCGCTAAGATCAGAATGTGAGAAGTATTTGGATATAGGGAAAGAATGAAGTGCCTTTCAAGTACATTAAAAATCAGTTAAGAGTTTACAGGAAAGAGACTGAGATTGGTAATCTGAAAAGGACCACAAGCATAGCTGGTAGGCAAATTGTTAGGCAGAATAATGGTATGTTGGAGAAATACACCTGTCTCTTATTCTTATCTCTTAAGAATTTTGGTTCTTCCCCCAGTGATTGCTGGTTGAATTCTTATATGGACAGGTTTCCCTTCCCCCAGTATCGCACATGGTTCTAGTTAGAATCCTGTTAGATAGTGAGCATCTGCTGTTAGCTAGACACTGTTGAATCAATACAGTGAAACAGACAGGTAAGCAGGTGGTTTTAATGCCTCATTCTAAGTGCTATTTAAATTGGATCTTGAAAGATGAATAAGGCCTGCCTTAAGTTCTGCTAAAGGCCATGTTGTTATTAAGGACGGGTGAGGAAGGACCAAGAAGTCTGGCTCCTGCTTTTCTACATGCCTGTGAAGGAGACTTTTCATGAAACTGAATAAAAGAAATCCTTTCCGAGATAGAGGAGATTTGTAGGTGAATGCAGAAGTGTATCCAGCTTTGAACCATGCATTCCATCTATATTCCTCCTGTCTGAACTCATGCTCTTTTGATTATGTTTTGAAATAAAGGGCTGCATTAGTTCTTTTAA

Publications

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