Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CNOT7P1
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:69935471-69938187  UCSC
Coordinates (T2T) chrX:68368821-68371537  UCSC
Coordinates (hg19) chrX:69155321-69158037  UCSC
Strand -
Parental Sequence NM_013354.7
Parental seq. overlap 2012 bp
Parental seq. overlap (%) 28.2%
Genomic Region Intragenic (EDA)
Retrocopy Summary CNOT7P1, located on chrX:69935471-69938187, is a retrocopy of the parental gene CNOT7. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CNOT7
Full Name CCR4-NOT transcription complex subunit 7
Also known as CAF-1|CAF1|Caf1a|hCAF-1
Coordinate chr8:17221981-17246857
Strand -
Gene summary The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CNOT7P3
Bonobo Pan paniscus CNOT7P3
Gorilla Gorilla gorilla CNOT7P2
Orangutan Pongo abelii CNOT7P2
Gibbon Nomascus leucogenys CNOT7P2
Green monkey Chlorocebus sabaeus CNOT7P2
Crab-eating macaque Macaca fascicularis CNOT7P2
Rhesus Macaca mulatta CNOT7P2
Baboon Papio anubis CNOT7P2
Golden snub-nosed monkey Rhinopithecus roxellana CNOT7P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CNOT7P1
AAGGATAAAATATTTTCTGAAACAAATCTTCAGTCAAGTATAACATTTTGATGCTTGAGAATATATGAGAATATATATATATTGTCATATAGAGAGAGAGAGCTAATAAAATTACCTGAGGAGTGTAATGCTTGTTTTTTTTGTGTATATCTTTGCAATCTATTTTACATATATTGACAAAAGAGACTGTGAAATATTTAGCCATGCAGAATATGTGACCAGACCAGAGCATGTGTAGGATGTAGGAAGACTTTTCGGTAATCATTAACCCTACCCTGAAATGATTGACTACAAGTTATAATGTGTATTACCTATACTTCAATCAATAATATTAGCAAATCTCCAAATGTTAGTCACATTGGTTTGTCTCCCTTGTACATTCTTTACTCATGATATTACAGTGCTGTAACTGGGTGGTCCTTTTTAAACAAAACATTATTTTCAAAACAGAGGGTATTACTTGTTTTTAAAGCTTTTGTAAATAAAGGCTTCAAAAATGTTTTCTTATAAAaCACATTTAGGTTAAATTTGGCCTTAATTTAATATACTTGTTAGCAAGCGTGTGTGACAGAGTGGAGAAAGCTACATCATTGAATATTTTGATAAACTTTACCTACTTGGGAGTTTGGTTTATTTCTCCCTTTTCCTAAATTAACTAGCACTGACTGTAATTTATTTCTCTGTTTCATGTCTCTCCCTTCCATTCTGCAGGAGTTTTAGCTATTTGAGATTGTGGACCATCAGTTTTGTACTTTGGAGAGTGATTCTAACTCAAAACCTCTGTTTTATCAGAAATGTTGTTTTTACTTGATCTTAGCTGGAAAAATGACCATCTACCAACTTTACACAGCATTTACTCGGTTTTGACCCACAGAATGTAGCACATTTATTGTGCAAACTGTCAATTCAGTGAAACTAAAAAAAAGACAAGAAACTACTGAGGAGCTTAGTAACTGCTGTTTCTGTACATAATGTTTAATCTTCCAAGCACATCTAGTGTCTGTCAGTTTTTAATTGGCATGTGTAGGCTGCTCTGTGACTGAAGACTTTTCAAACCAGTCTTACCCCCTTCAGGAAAAATTCCTTGTGATTGAATACTTAGTATCTGCCAGGAAACTGGTACTCAAGATGTTGAAGCTACAGTTACTTTATGATAGCACACTTCCCTTGATCTGCTTATTTTTATTCCATCACTGTTTACCCTTGTTTTTTTAATTTCGTAGCCATACTTATGATGCTCTTGATTTGTTGGTTATACAAATTGATTTTTTTTAAAATCCAAAGATAACAAGTCTTTAGGTATATTTTGTACCAAATTAAATTAGAAGTCAAAAATTGTGCTTTCCTAGTTGCTACAAAGGTAAATAATGGAGAGATTTGGTACAAAACAAAATCCCCGCCACTGCCACTGCCGCCGGGTGCTGTCTCTATGGCCAGGGGGAGGAGGAGGAGTGAGAGCTCAGTGACACAAGTACATAAATAAAGGACAAAATATTCTCTGAAACAAATCTTCAATCAAGTATAACATTTTGATGCTTGGCATCTAGACTCCCTTGTGCCCTCACTATGCCAGCAGCAACTGTACATCATAGCCAAAGAATTTGTGAAGTTTGGGCTTGCAACGTGGATGAAGAGATGAAGAAAATTCATCAAGTTATCCGAAAATATAATTACGTTGCTATGGACACCGAGTTTCCAGGTGTGGTTGCAAGACCCACTGGAGGATTCAGGAGCAATGCTGACTATCAATACCAACTATTGCGGTGTAATGTAGACTTGTTAAAGATAATTCAGCTAGGACTGACATTTATAAATGAGCAAGGAGAATACCCTCCAGGAACTTCAACTTGGCAGTTTAATTTTAAATTTAATTTGACAGAGGACATGTATGCCCAGAACTCTATAGAGCTACTAACAACATCTGGTATCCAGTTTAAAAAACATGATGAGGAAGGAATTGAGACCCAGTACTTTGCAGAACTTCTTATGACTTCAGGAGTGGTCCTCTGTGAAGGGGTCAAATGGTTGTCATTTCACAGCAGTTACAACTTTGGCTATTTAATCAAAATGCTGACCAACTCTAACTTGCCTGAAGAAGAACTTGACTTCTTTGAGATCCTTCGATTGTTTTTACCTGTCATTTATGATGTGAAGTACCTCATGAAGAGCTGCAAACATCTCAAAGATGGATTACAGGAGGTGGCAGAACAGTTAGAGCTGGCATAGATAGGACCACCACATCAGGCAGGATCTAAATCATTGCTGACAGGAATGGCCTTTTTCAAAATGAGAGGAATGTTCTTTGAAGATCATACTGATGATGCCAAATATTGTGGTCATTTGTATGGCCTTGGTTCTGGTTCATCCTATGTACAGAATGGCACAGGGAATGCATATGAAGAAGAAGCCAACAAGCAGTCATGACATGAAATAGTCCTTTTATTTTTATTTTATTTTGAGCTACACACATGCTTGTATATAGGTTTTATCTCTGGTTGAATCCTTTGAACAACAGACAGTCCCTTCCCCCCGCCCTTTCATGGCCCATTTTATTGTCTGCCTTTCAGTACTAAGTATGATCGTTCCTATCTCAGATTa
>NM_013354.7
GTGCGAAAAGCGACGGCGCAGCACGGTGCGGCGCAGCTCCTGCTCGCCTTTCCCTTCGCTGGGCGAGAGGTGTCTATGGGGCACCCGCTGccgccgccgctaccgccaccgccaccgccaccgccGCCGAGTGCTGTCTCTATGGCgaggaggaggaggaggagCGCGAGCTCAGCGACACAAGTACATAAATAAAGGATAAAATATTTTATGAAACAAATCTTCAATCAAGTATAACATTTTGATGCTTGGCATCTAGACTCCCTTGTGCCCTCACTATGCCAGCGGCAACTGTAGATCATAGCCAAAGAATTTGTGAAGTTTGGGCTTGCAACTTGGATGAAGAGATGAAGAAAATTCGTCAAGTTATCCGAAAATATAATTACGTTGCTATGGACACCGAGTTTCCAGGTGTGGTTGCAAGACCCATTGGAGAATTCAGGAGCAATGCTGACTATCAATACCAACTATTGCGGTGTAATGTAGACTTGTTAAAGATAATTCAGCTAGGACTGACATTTATGAATGAGCAAGGAGAATACCCTCCAGGAACTTCAACTTGGCAGTTTAATTTTAAATTTAATTTGACGGAGGACATGTATGCCCAGGACTCTATAGAGCTACTAACAACATCTGGTATCCAGTTTAAAAAACATGAGGAGGAAGGAATTGAAACCCAGTACTTTGCAGAACTTCTTATGACTTCTGGAGTGGTCCTCTGTGAAGGGGTCAAATGGTTGTCATTTCATAGCGGTTACGACTTTGGCTACTTAATCAAAATCCTAACCAACTCTAACTTGCCTGAAGAAGAACTTGACTTCTTTGAGATCCTTCGATTGTTTTTTCCTGTCATTTATGATGTGAAGTACCTCATGAAGAGCTGCAAAAATCTCAAAGGTGGATTACAGGAGGTGGCAGAACAGTTAGAGCTGGAACGGATAGGACCACAACATCAGGCAGGATCTGATTCATTGCTCACAGGAATGGCCTTTTTCAAAATGAGAGAAATGTTCTTTGAAGATCATATTGATGATGCCAAATATTGTGGTCATTTGTATGGCCTTGGTTCTGGTTCATCCTATGTACAGAATGGCACAGGGAATGCATATGAAGAGGAAGCCAACAAGCAGTCATGACATGAAATAGTCCTTTTATTTTTATTTCGAGCTACACACATGCTTGTATATAGGTTTTATCTCTGGTTGAATCCCTCGAACAATAGACAGTACCTTTCCCCCCCCTTTCATGGCCCATTTTATTGTCTGCCTTTCAGTACTAAGTATGACCGTTCCTATCTCAGATCTTAATAAAAAGAAAAAAAAAAACGCATTCAGGTTAAATTTGGCCTTAATTTAATATACTTGTTAGCAAGCGTGTGTGACAGAGAGTGGGGAAAGCTACATCATTGAATATTTTGATAAACTTTACCGACTTGAGTTTGGTTTATTTTTCCCTTTTCCTAAATTAACTAGCACTGACTGTAATTTATTTCCCTGTTTCACGTCTCTCCCTTCCATTCTGCAGGAGTTTTAGCTATTTGAGATCGTGGACCATCAGTTTTGCACTTTAGAGAGTGTTTCTGACTCTAAACCTGTTTTATCAGAAAATTTGTTTTTTCTTGATCTTAGCTGGAAAAATCTGCCAACTTTACACAGTATTTACTTGGTTTTGACCCACAGAATATAGCACGTTGTGCAAACTGTCGATTCAGCGAAACTTAAAAAAGACAAGAAACTACTGAGGAGCTTAGTAACTGCTGTTTCTGTACGTAGTGTTTAATCTTCCAAGCACATCTAGTGTCTGTCAGTTTCTAATTGGCATGTGTAGGCTGCTCTGTGACTGAAGAATTTTCAAACCAGCTTTACACCCTTCAGGAAAAATCCCTTGTGATTGGATGTTTACTATCTGCCAGGAAACTGGTACTCAAGATGTTGAAGCTACAGTTATTTTATGATAGCACACTTCCCTTGATCTGCTTATTTTTATTCCATCACCATTTACCCTTTTTTTTTTTTTAAATTTTGTAGCCATTCTTATGATGCTCTTGATTTGTTGGTTACACAAATCAATTTTATTAAAAATCCAAAGATAAGTCTTTAGGTATATTTTGTACCAAATTAAATTAGAAGACAAAAATTGTGCTTTCATAGTTGCTACAAAGGTAAATAATGGAGAGATTTGGTACAAAACAACAAAatatatatatattctcatatatatatatataGCTGATAAAATTACCTGAGGAGTGTAATGCTTATTTTTTTGTGTATATCTTTGCAATCTATTTTATATATATTGACAAAAGAGACTGTGAAATACTTAGCCATGCAGAATATGTGACCAGACCAGAGCATGTGTAGGAAGACTTTACGGTAATCATTAACTCTACCCCGAAATGATGGACTACAAGTTATAATGTGTGTTACCTACACTTCAATCAGTAATATTAGCAAATCTCCAAATGTTAGTCACATTGGTTTGTCTCCCTTGTACATTCTTTATTCATGATATTACAGTGCTGTAACTGGGTGGTCCTTTTTAAACAAAACATTATTTGCAAAACAGAGGGTATTATTTGTTTTTAAAGCTTTTGTAAATAAAGGCTTCAAAATGTTTTCTTATAAATGTTGATGACTGGTGATTTTCTTTTGGAAATACTTATTTGGGGGATATTGTTCATTTTTATTTGGGCAACTCAACAGAATTCAGTAACTTCCTTCATTAACCCTAGATGATTATTAGTCCATTAATTGAAAAATCAGTCTGAGTTTTCTGCATTTCAAGTGTTGGCTTATTCTTGTTCTTTATGAGTACCTCAACTAGCTAATTAAGGACTGACTTCTGTTTCTCCTTTCCAGGAATGCATTTATTCCGAAGGATATACTTCACAAAGTAAATACATTTGGTATAACTGTGGCTTTTTAAAAAATCTAACACAATGTAGTAAGTTTCTAACTGGCTTCTTTTGTCTTCGTTAAAAAGGAAGTGAAGCTTCTTTTCGCTTGTGATTTGTTAGCTGAGAAAACTAATATTTAAATTCTGTTCAACTATTTGAGAAATCAATGCTGGATTTCAAATAGGAATGATAAAGATTGCCTTTTTATTAGCCACATAGTTGCTCAATCTCATAACTTGTATCATTTCTGGCTTCTGTCCCTAAAAAGTATagataatccctaacttactttcgacttaatgatttttcaactttacagtgggtgtattgagaggtaaccccatcaaaagtttaggagcgcctTAGGACCAAAGATGGGGTtatagtttctactgaatgtgtattgcttttgcaccattgcaaagtcaaaatttataacttgaaccatcgtaaattgggggactgtatgCTGTTGCCTGCATTAAATGCATCTTAGTATTTTTTCAGATGTAACCTCATTGTAGGTTGAGCAACCGTATAGTGTAACTTTTGTAGAGGAACATTTTGACTTTTACTGGGTCTAAGTTTTACTTTTTTATTTTGTTCCAGACAGTCTCAATGTTTGTAAAGTCTAGGTTCCAGATGTAAGATATTTGGCTGATATTTTAGTGTTACTGAGCCATTAATTAATTACAGGCTCATATATTCTGTTAAATCTACTAGAGcaagggttgtcaaactatggcccgtagccagaatcagcttgctgcctgtttttgtgtggcccatgaactgaaaatggcttttaaatggttgggaaaaataatcaaaagattatttcctgacatctgaaaattacatgaaattcaaattttagtgtctataagtttttattggaatgcagccacactaatttacatattatctatggatacttttttgctataatgggaaagttgagtagctgctacagaacctgtgtatgtgtgtcttgtttcacattgccgcttggcaagctacagaatcatggtgatgcagatattacctgaaagcatttggaatgccctgtgtattgctagatttattactttttctgctaccagttcatgccctgtatctcagaacaagaaaagtacctttgaatgttacactttcaaggcacattggaatatggactattttattatatgctggtacattgtgtttataatgcagtgtcaccataactggtaaaagaatagactgacagtatcagactaacatcacaatattcccaactggtgggaaagcaacagtcagaagaattagaaaatttaaatgaaacatcacagcaaaatttcacaaaagtaataaaaatgaggctgcaaccaaaatgtttacaagtagcctatttgttagccaagcaaagaaaaccatttactaatgctgaattacatcgtgcttgaagatagtaaccaacccaaagacatgtgtccagagaaaattaagacatcagccctttgatgagaacagtagtttgaagaatgaggattttggacacaacatcaaATGACACTGTTAATTCTTTGCCTCTTACTAGTCAGtactgcctagctttattttttgagaaaccattgctggatttgaagtgatcgaagaatttgtatggaactacaagtgggaatattttcaaaaaagttgataaacagtacaacctgaagtggaatctactaagatgtgatgcaaccgatgctgggaaaaatgcatgaagcagaaaaaaagtttatttggtcaaattttaaggcttgtgaaaacgtaagttgtttaaagcctgtagttactcacttgattattcatcagcaggtacttcacaggaaatattggtgttactgaactggtcaacagttaacttcatttgctcttgtggacttaaccatcttcagttccatgatttttttttttttgtgagaaacagaagctgaatatcctgatttgatttgccacacaggcgttcaatggcttagcagtgctaaagatttatttttatttttttgggctctgggctgacattgaaatttttctgaatgagaaaaaccatcctcaaccactgttttttaacactgagtaactttggaaattaacttttgccacagacttgaaaatgtttcttaatgaatttgacctgaaattacaaggtacaacaacataatatggtaaattcatttcaataaaaactaaaacttaagattgtcaagctgctttatatactttctgtgctatgagaagtcaaaacagcgctgtattgccaaatccatttttagtggatatattttcctgtagcagttttttggaccttgatgcagtgcaaagaaaatttttaaattttaaaagcatttaactgcaattaaatgcttttaaagtttcctcttaatcttctgttggaaatgaatcatcttgaatgaatgacatgctaaagggcaaataccaaaaagatgaatcctacaaatgccttacaagtgatgaatatgcttaactaaaatcacatgctcatgggtggatgtgtcagtatttagcagtaccttgacctgtttgtgtgaaaagacattttcaaagatgaaatacgtgaaatcccattacacatcagcattaacagattaacattttctatttattccaatgaggggataccaactttcagcccaaattgagcaaaatgttacctcccgtcccctgccaaaaaatcccattattcccattagtagaactctattactaaaaaaagaaaaaaaaattgtactcaatattttgagttttcaatttttagaataaaaatttggtgaaaagtttccttgagtacctaaataatgtccttcattttgtcttagcttgcaaagcctctaatatttgctacctgcccttttCaaaaaaaaaaaaaaaaaaaaaaaaaaGGCTTGTCCACCTCTCTACTAGAAGAAACTCAAGGGTCTATGTCTGTCCTGTTTGCTATTTCATCTGCATTGCCAAATGCAGTGGCTCCTCTGGGTAGGCAACCTGAGGTGGAATCAAATTATGAATGCATATGTTATCTCATGTCTATAAAATAAATGTGTTAGAATTTATAAATAAAGGGATAGGAAAAATGCTGATTATTCTGTGTGTCGGTGCTTTGTAGTGAAGGCCAGTTCACACATGCCATTTGCTATGTTGGTGTAATTTATATGAGAGTTTCTTTTATAACAACGTTACCTGTCATTTATTTTTCTATTAAGACATTATAGAAACGTAGGACTGTACACATCCAAATCCTGCAGAATTTTCATTTCAGGTTTTGAAAGTTAAAAAAATGTCACCATAGAATGAAAATTCCAAGAAAACAAGATTCATGTACATTATCACTAGACAATTTCCATTTGTTTTAAACAGTTTTCTACAGCATTAGTTACATTTAACGTTTAGTATAAAAGCAATTGAGCAATTTCTCTTTAGAAGTCCATTTCATTGCTTTGTAGCCATAGTCTGTAGGTGAATGAACAAGCTACATTTCTCCAGAATTACTCATTTTCTTTTTAAAGATAAACTGGTCAATACTCTCCTTCCTGGTATGGAGGAATTTTTTGTATATGAGAAGCATTCATGAATATAATCTGCCCTCTTGCTTTATTGTCATAGGAGGGGAAATTCACTGCTTTCACACCCTTCTGTTTTGGCTCTTTCTCCCAAAAGATAAGAATCTTTATTTAGTATCATACCAAGAAATTGGAGTTCCTTTAGCTTCAGACTATCATCATGGCTTCCAAATTGTTAGGAAATACAAGTTTGCAAGACCCCAAGGGGACTTAATATTTTACATCTTACTAGCCATGTCATAGGTTTTAAGTGCTTTTAATGGGGAACTGTTTCACTCATGCCATATACCTGTTTTGTTTTTCTAAAAAATTAATACTGTAAGTTGTGAGCAGGTGTCTTGTATCACTGCGAAACCCATGCATAATAAAAACTTGTTCTTGAGCTA

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