Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ZCRB1P1
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:71312324-71315996  UCSC
Coordinates (T2T) chrX:69746426-69750098  UCSC
Coordinates (hg19) chrX:70532174-70535846  UCSC
Strand -
Parental Sequence NM_033114.4
Parental seq. overlap 723 bp
Parental seq. overlap (%) 29.2%
Genomic Region Intergenic
Retrocopy Summary ZCRB1P1, located on chrX:71312324-71315996, is a retrocopy of the parental gene ZCRB1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ZCRB1
Full Name zinc finger CCHC-type and RNA binding motif containing 1
Also known as MADP-1|MADP1|RBM36|SNRNP31|ZCCHC19
Coordinate chr12:42312086-42326107
Strand -
Gene summary Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ZCRB1P3
Bonobo Pan paniscus ZCRB1P3
Gorilla Gorilla gorilla ZCRB1P3
Orangutan Pongo abelii ZCRB1P4
Gibbon Nomascus leucogenys ZCRB1P3
Green monkey Chlorocebus sabaeus ZCRB1P2
Crab-eating macaque Macaca fascicularis ZCRB1P3
Rhesus Macaca mulatta ZCRB1P3
Baboon Papio anubis ZCRB1P1
Golden snub-nosed monkey Rhinopithecus roxellana ZCRB1P1
Marmoset Callithrix jacchus ZCRB1P6
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ZCRB1P1
GAGAGTCTTTAATTTTCTACTTTGTATATTTCTATATTAACTTTGAAAGAACACCCATTTATTACCTTTTAACTAGTAAAAGCAATAAAAATAAGAAAAGTTAATACTATCATAGTAATACTATTGTTGTCATTCCAAGAAAAAAATATATTAAAAATATTTATTTGAAAAATTCTGTCTGCAGGTAGTTATATGGGAATGGGATTAGAGAATCCACAAACTTCCTGAAGACCGAAAAGTTGAATGATTTATTGTTATTTATGTTAATACACTTTTCATGAAAATTTTGTCTTTAAATATGGGTGTTTTGTCATATTTCTTGTAGCTTTATCCCAATCTGGATAAATTGTAAATACCTATAAAATAAATTGTAAATACCTAATAAAATATAAAGTAACATAGCTCTAAAAGGCTTAAAATCAAACACAGGTGTTATTTGTCTGCCCTACCCATAGCACCAAATTCCATTCCCTAGAAGAAACTACTCATATGTGCATGCATGTCGCTAAATAAAATACATATATTTCTGTCACTTAATAAAAGAATAAAGGGGATTATTCAATCTCTTATACTTCTCCTACCTGAAAAAAGATATTTTAAAATTTTATTTGAGCTCCTGAACCAGAAGAAATTGAGGAAGTAGTAGAAAGTGAAGATGAAGGGGAGAATCCTGCTCTTGACAGCCTCAGTCAGGCCATAGCATTCCAGCAAGCCAAAATTGAAGAACAAAAAAAATGGAAACCCAGTTCAGGAGGCCCCTCAACATCAGGTGAGTCAAGACCCCCAAGGATAAAGAACAGCACATATTTCCGTGATGAGGAAGAACTTAGTGATTAAAATCTTGCCCTAGCACAGTAATAAAAATCAAGATTTGTTAGTAACAATCTTGACGATCTAATTTTAATAAAAATAAGAATACTATCATGTTAATACTATTACTGTCATCCCAAGAAAAATGATATAAACAAAAAAAGAGGAAGCATTGCTATTGACAATGGAAGAGCAGCTGTGTTCATCTGAAGGCGAAACTACTTTGATAAATCCAAGTGTTATGAATGTGGGGAAAATGGACACTTAAGTTATGCCTGTCCGAAAAATATGCTTGGAGAACGTGAGCCTCCTCCCAGGACTCGTGATGCCAAGGCCGCTGCGAGCAGCTATGAAGAGTCGGGGTTGAGCCCCAGCTGAGCCGAGGGCTCGCACTCTTCTGGTCTCCCAGGACCGTCACACCTGAAGAAATGAGTGGTGGATTGGCTCCAAGTAAGAGCACAGTGTATGTATCCAGCTTGCCCTTTTCCCTGACAATGACTTGTACCGGATATTTTCCAACTATGGCAAAGTTGTAAAGGTTACCATAATGAAAGATAAAGATATCAGGAAGAGTAAAGGGGTTGCATTTATTGTATTTTTGGATAAAGACTGAACAAAACTGTACCAGGGCAATAAACAACAAACAGTTATTTGGTAGAGTGATAAAAGCAAGCATTg
>NM_033114.4
AAACAGTCGGGAAGAAGCACCGTGGCTGCTATTATCTGCTCTCCGCGCCTGACCCCTCCCAGGACTCGTGATGCCAAGGCCGCTGCGAGCGGCTACGAAGAGTCGGGGTTGAGCCCCAGCTGAGCCGAGGGCTCGCACTCTTCTGGTCTCCCAGGCCCAACCCACCTGAAGAAATGAGTGGTGGATTGGCTCCAAGTAAGAGCACAGTGTATGTATCCAACTTGCCTTTTTCCCTGACAAACAATGACTTGTACCGGATATTTTCCAAGTATGGCAAAGTTGTAAAGGTTACCATCATGAAAGATAAAGATACCAGGAAGAGTAAAGGGGTTGCATTTATTTTATTTTTGGATAAAGACTCTGCACAAAACTGTACCAGGGCAATAAACAACAAACAGTTATTTGGTAGAGTGATAAAAGCAAGCATTGCTATTGACAATGGAAGAGCAGCTGAGTTCATCCGAAGGCGAAACTACTTTGATAAATCTAAGTGTTATGAATGTGGGGAAAGTGGACACTTAAGTTATGCCTGTCCGAAAAATATGCTCGGAGAACGTGAGCCTCCaaagaagaaagaaaaaaagaaaaaaaagaaagctcctgaaccagaagaagaaATTGAGGAAGTAGAAGAAAGTGAAGATGAAGGGGAGGATCCTGCTCTTGACAGCCTCAGTCAGGCCATAGCATTCCAGCAAGCCAAAATTGAAGAAGAACAAAAAAAATGGAAACCCAGTTCAGGAGTCCCCTCAACATCAGATGATTCAAGACGCCCAAGGATAAAGAAAAGCACATATTTCAGTGATGAGGAAGAACTTAGTGATTAAAATCTTGCCCCAGCACAGTAATAAAAATCAAGATTTGTTAGTAACAATCTTGAAGAGCTAATTTTAATAAAAATAAGAAAAATTAATACTATCATGTTAATACTATTATTGTCATCCCAAGAAAAAAGATATTTTAAAAATTTATTTGAAAAGTTCATTATAAGGGCTTTATTCATGCCTGATTTGTTTACATGAGGACTTCTGAAATTAATCCTTAAAACAAACTTCCTGAAGACCGAAAAGTTGAATGATTTATTGTTACTTATATTAATAAACTTTTCAAGAGAATTTTGTCTTTAAATATGGGTGTTTTGTCATCATATTTCTTGTAGCTTTATCCCAATCTGGataaattgtaaatacctataaaataaattataaatacctataaaatataaagtaACATAGCTCTAAAAGGCTTAAAATCAAACACAGGTGTTATTTGTCTGCCCTACCCATAGCACCAAATTCCATTCCCTAGAAGAAACTACTTACATGTGCACACATGTAGCTAAATAAAGTACATATATTTCAGTCACTTAATAAAAGAATAAAGGAGAATTATTCAATCTCTTATACTTCTCCTACCttcctcaatattcccaatgtggctgtattaaaaatttgggggaatccatatatatcttttttaataaccaagtaaatacttttcatttctgagccaaggaatatgctatgattacgttttttcctagagttaataattgtctattttttttccatgtattgtctttgtatttatgactaaatcttcccATTCTGTCTGCAGGTGGGTATATGGTAATGGGATTAGAGAGCCTTTAATTTTCTGCTTTGTATATTTCTATATTGTTTAACTTTGTAAGAATGCCCATTACTTTTTtaactagtaaaagcaatagaaataagttaatactatcatagtaatattattaTTGTCATCCCAAGAAAAAATATATTAAAAAGATATTTGAAATTTCA

Publications

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