Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DDX3P1
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chrY). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:74130566-74131921  UCSC
Coordinates (T2T) chrX:72564104-72565459  UCSC
Coordinates (hg19) chrX:73350401-73351756  UCSC
Strand +
Parental Sequence NM_004660.5
Parental seq. overlap 1234 bp
Parental seq. overlap (%) 28%
Genomic Region Intergenic
Retrocopy Summary DDX3P1, located on chrX:74130566-74131921, is a retrocopy of the parental gene DDX3Y. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DDX3Y
Full Name DEAD-box helicase 3 Y-linked
Also known as DBY
Coordinate chrY:12903999-12920478
Strand +
Gene summary The protein encoded by this gene is a member of the DEAD-box RNA helicase family, characterized by nine conserved motifs, included the conserved Asp-Glu-Ala-Asp (DEAD) motif. These motifs are thought to be involved in ATP binding, hydrolysis, RNA binding, and in the formation of intramolecular interactions. This protein shares high similarity to DDX3X, on the X chromosome, but a deletion of this gene is not complemented by DDX3X. Mutations in this gene result in male infertility, a reduction in germ cell numbers, and can result in Sertoli-cell only sydrome. Pseudogenes sharing similarity to both this gene and the DDX3X paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DDX3YP1
Bonobo Pan paniscus DDX3XP2
Gorilla Gorilla gorilla DDX3XP2
Gibbon Nomascus leucogenys DDX3XP2
Green monkey Chlorocebus sabaeus DDX3YP1
Rhesus Macaca mulatta DDX3XP2
Baboon Papio anubis DDX3XP2
Golden snub-nosed monkey Rhinopithecus roxellana DDX3XP2
Orangutan Pongo abelii Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DDX3P1
ACTATACTCATCCTACTCCACTGCAAAACATGCCATTCCTATTATTAGGGGAAAAAAAGAGACTTAATGTCTTGTGCCCAAGCAGGGTCTGGGAAAACTGCAGCATTTCTTTTACCCGTACTGAGTCAGATATATATAGATGGTCCAGGAAAAGCTTTGAAGGCTGTGAAGGAAAATGGAAGGTATGGATGCCATGAACAATACTCAATCTCCTGGGTTTTAGCCCCAACAAGAGAATTGGCTGTACAGATATGAGGAAGTCAGAAAATTTTCATACCAGCCTAGAGTTCATCCTTGTGTAGTTTATGGTGATGCTGATATTGGTCAGCAAATTCAGGTCTTAGAACATGGATGCCACTTGTTAGTAGCCACGCCAGGAGGTCTAGTGGATTTGATGGAAAGAGGAAAGATTGGATTAGACTTCTGCAAATACTTAGTGTTGGATGAAGCTGATAGGATGCTGGATATGGGATTTGGACCTCAGATACATCTTATACTTGAACAAGATACTATGCCACTGAAGGGCATTCATCACATCATGATGTTTAGTGCTACTTTTCCTAACGAAATACAGATGCTTGCTCGTGACTTTTTGGATGAATATATCTTTTTGGCTGTAGGAAGAGTAGGCTCTACCTCTGAGACTATCACACAGGAAGTAGTTTGGGTGGAAGAGCCAGATAAACGGTCATTTCTGCTTGATCTCTTAAATGCACCAGGGAAGGATTCACTGACTTTAGTGTTTGTGGAGACCAAAAAGGGAGAAGATTCTCTGGAGAATTTCTTATACCATGAAGTATATCCTTGTACTAGTATTCATGGAGACCAATCACAGAGAGATCGAGAAGGAGGCCCTTCATCAGTTTTGCTTGGGGAAAATCCCAATTCTAGTGGCTACAGCTGTGGCAGCATGAAGACTAGACATTTCAAATGTGAAACATGCTTCAATTTTGATTTGCCAAGTGATATTGAAGAATATGTGCCTTGTATTGGCTGTACAGGATGTGTGGGAATCCAGGGTCTTGCCACCTCATTCTTTAATTAAAGAAATATGAATATTACAAAGGATTTGTTGGATATTCTTATAGAAGCTAAACAAGAAGTGCCTGCTTGGTTGGAAAATAAAGCTTATAAACACCACTACAAGGGTGGTATTCATGCATGATCTAAAAGATTCAGTGGAGGATTTGGTGCCAGAGACTATTGACAAAGTAGTGGTTCCAGCAGTTCTGGCTTCAGTAGTAGTCATACAAGCAGCAGCTGCAGTGGTGGAGGTGGTCATGGCAGCAGCAGCAGATGTGGTGGAGGTAGCTATGGAGGCTTCTACAACAGTGATGGATGTGGAGGAAATTATAA
>NM_004660.5
AGTGTAAGAGTTCCGCTATTCGGTCTCACACCTACAGTGGACTACCCGATTTTTCGCTTCTCTTCAGGGATGAGTCATGTGGTGGTGAAAAATGACCCTGAACTGGACCAGCAGCTTGCTAATCTGGACCTGAACTCTGAAAAACAGAGTGGAGGAGCAAGTACAGCGAGCAAAGGGCGCTATATACCTCCTCACTTAAGGAACAGAGAAGCATCTAAAGGATTCCATGATAAAGACAGTTCAGGTTGGAGTTGCAGCAAAGATAAGGATGCATATAGCAGTTTTGGGTCTCGAGATTCTAGAGGAAAGCCTGGTTATTTCAGTGAACGTGGAAGTGGATCAAGGGGAAGATTTGATGATCGTGGACGGAGTGACTATGATGGTATTGGCAATCGTGAAAGACCTGGCTTTGGCAGATTTGAACGGAGTGGACATAGTCGTTGGTGTGACAAGTCAGTTGAAGATGATTGGTCAAAACCACTTCCACCAAGTGAACGCTTGGAGCAAGAACTGTTTTCTGGAGGAAACACGGGGATTAACTTTGAGAAATATGATGATATACCAGTAGAGGCAACCGGCAGTAACTGTCCTCCACATATTGAGAATTTTAGCGATATTGACATGGGAGAAATTATCATGGGGAACATTGAACTTACTCGCTATACTCGTCCTACTCCAGTGCAAAAACATGCCATTCCTATTATTAAGGGAAAAAGAGACTTAATGGCTTGTGCCCAAACAGGATCTGGGAAAACTGCAGCATTTCTTTTACCCATACTGAGTCAGATATATACAGATGGTCCAGGAGAAGCTTTGAAGGCTGTGAAGGAAAATGGAAGGTATGGGCGCCGCAAACAATATCCAATATCCTTGGTTTTAGCCCCAACAAGAGAATTGGCTGTACAGATCTATGAGGAAGCCAGAAAATTTTCCTACCGATCTAGAGTTCGTCCTTGTGTAGTTTATGGTGGTGCTGATATTGGTCAGCAGATTCGGGACTTAGAACGTGGATGCCACTTGTTAGTAGCCACTCCAGGACGTCTAGTGGATATGATGGAAAGAGGAAAGATTGGATTAGACTTCTGCAAGTACTTAGTGTTGGATGAAGCTGATAGGATGCTGGATATGGGATTTGAACCTCAGATACGTCGTATAGTTGAACAAGATACTATGCCACCAAAGGGCGTTCGTCACACCATGATGTTTAGTGCTACTTTTCCTAAGGAAATACAGATGCTTGCTCGTGACTTTTTGGATGAATATATCTTTTTGGCTGTAGGCAGAGTAGGCTCTACCTCTGAGAACATCACACAGAAAGTAGTTTGGGTGGAAGACTTAGATAAACGGTCATTTCTACTGGACATTTTAGGTGCAACAGGGAGTGATTCACTTACTTTAGTGTTTGTGGAGACCAAAAAGGGAGCAGATTCCCTGGAGGATTTCTTATACCATGAAGGATATGCTTGTACTAGTATTCATGGAGACCGGTCACAGAGAGATCGAGAGGAGGCCCTTCACCAGTTTCGCTCAGGAAAAAGCCCAATTCTAGTGGCTACAGCTGTGGCAGCACGAGGACTAGACATTTCAAATGTGAGACATGTTATCAATTTTGATTTGCCAAGTGATATTGAAGAATATGTGCATCGTATTGGCCGTACAGGACGTGTAGGAAACCTGGGCCTTGCCACCTCATTCTTTAATGAAAAAAATATGAATATTACAAAGGATTTGTTGGATCTTCTTGTAGAAGCTAAACAAGAAGTGCCTTCTTGGTTGGAAAATATGGCTTATGAACACCACTACAAGGGTGGCAGTCGTGGACGATCTAAAAGTAATAGATTCAGTGGAGGATTTGGTGCCAGAGACTATCGACAAAGTAGTGGTTCCAGCAGTTCTGGCTTTGGTGCTAGTCGCGGAAGCAGCAGCCGCAGTGGTGGAGGTGGTTACGGCAACAGCAGAGGATTTGGTGGAGGTGGCTATGGAGGCTTCTACAATAGTGATGGATATGGAGGAAATTATAACTCCCAGGGGGTTGACTGGTGGGGCAACTGAATCTGCTTTGCAGCAAAGTCACCCTTACAAAGAAGCTAATATGGAAACCACATGTAACTTAGCCAGACTATATTGTGTAGCTTCAAGAACTTGCAGTACATTACCAGCTGTGATTCTCCTGATAATTCAAGGGAGCTCAAAGTCACAAGAAGAAAAATGAAAGGAAAAAACAGCAGCCCTATTCAGAAATTGGTTTGAAGATGTAATTGCTCTAGTTTGGATTAAACTCTTCCCCTCCTGCTTTAGTGCCACCCCAAACTGCATTTATAATTTTGTGACTGAGGATCGTTTGTTTGTTAACGTACTGTGACTTTAACTTTAGACAACTTACTACTTTGATGTCCTGTTGGCTCAGTAATGCTCACGATACCAATTGTTTTGACAAAATAAATTTACTAAACTTGGCCTAAAATCAAACCTTGGCACAGAGGTATGATACAACTTTAACAGGAGTCATCAATTCATCCATAAATATAAAAAGGGAAAAAAACTTAAGGCAGTAGTCTGCATTAGGACTGTTTGAGTTTTGCAGACTTGGGGTTGGGAGAACATCTTAAAGCATTAAAGCATAGTTTTTTGTATGGCCAACCTTACTAAATTAAGTTCTGACTTGCTCACTCTATCCTGGATAGGCACTTGGGAACTTACACTCTTTAAGCCATTCCAGTCATGATGAGGTGGAATGTATCAGTATACCAATTAATATTTTTGAAAGAGCTCTTTTAGGTTAATTTAAGTACAGCAATTTCTCATGTAATGTTTAGGGAGTTTATTCTAACCTAGGCAAACGGCATGCTATCACAAGAAAGGTTTAAAGCTTTGATAAAATGGGGGAGATTTAATCAGTTTTTTTAATGCCTGCTATAAAAATTTGAAATATTAGAATGGCCGACCATGGCAGTGACCAGGCCTCACTACAGGCCTGGTTGGATTCTGGTCTTTAATGCATGCTAGTGTTGATGTTTTTTGGTCAAGAACGGTTTAAACAGGAAGGATTGTGCAGCAGGCTTTAATTTAATGTAGATTCATACTGCTCTGTTAAAGCTGCATTGAAATGTTAAAATGGCTTACACTTGCAGACTTTGCAAATCTTAAGACTAACAAATCCTTGAAATCACACAGCTTGCAAATACGTACTAAACTGCACAAGGTGTGTGTTCTATATGTGCAGTTTTAGCGTATTTTAGTTGCATAGGTTTCCATGGTATTTATAGTCTCTTGTGCTAAATTTGGCCAAAGATGATTGTCCACCACTAAAAATGCCTCTCCCACTTGGAATTCTGTACTGATTTTGTGGCCAGATGCAATGATCTTTAAAAACAAATCTTTTCAATGGCATAAGAAGTTGACAAAAATTTCTTAAAGTGCAATAGATTTTCAAGTGTATTGTGCCTTGTTCTAAAACTTTTAAGTAGGTGCACTTGACAGTATTGAGGTCATTTGTTAAGGTGCTATTTCAATTAGTGTAGGTTTAGACTCTTGTACATTTCTCCCATAACTTTTTACAAAGTATTTTGTTGCACATTCAGAGAATTTTATATATATATGTCTTGTGTGGGTGTCCTCGACCTTCCAATCTTATTTCGTCTCTTGGAGATTGTTGAATGCAGCCAGTGAAGAAGTAGATTCCTAAATTTTATTGGGGACCATGGAATGGTAGTTGAGAAGAAAACTATTTGCACACAACAGATTTTAGATACTTTTTGCTGCTAGTTGTGTAATATTTATTGAACATTTTGACAAATATTTATTTTTGTAAGCCTAAAAATGATTCTTTGAAAGTTTAAAGAAACTTGACCAAAAGACAGTACAAAAAACACTGGCACTTGAATGTTGAATGTCACCGTATGTGAAATAATATATTTTGGGGTAGTGTGAGCTTTTAATGTTAAGTCTGTTAAACTTGAGTCAAATTAAGCAGACCCGGCATTGGCAATGTAGCTGTAATTTTCTGACAAAATTTAAGACAAAATTGTCAACTTGAAACTAAAACATGCCAAGGTTTTGATATACTTGTCTTAAGATATTAATGAAACACTTCTGAACACTGATAGGAAGTGTCCACATCCACAAAGTTTCTCTTGAgttttgttatgtgttttgttgtgtttgattttCAGTGATTGTCTGGTATATTTACAGTCCTCAAACATGGTTATTTCTGTCAGTGACTTAACATTCGGTTTTATCAGCCAGCAGTATTCTTCAGTAAATAAAGAATGGAATTGCTGAATGTAATCATTGAACCTCGAGTCACTGTAAAAGTTCAGTAATTGCTTATTGTATTAGTTTTAGATGCTGGCACTGCATGTGCTCTGTTTATTCTGATTTTACTAAAATAAAAAGTTCAAAAGTC

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