Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name RPL27AP8
Wait
Plot displaying the genomic locations of a retrocopy (in chr13) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr13:47766606-47767098  UCSC
Coordinates (T2T) chr13:46986941-46987433  UCSC
Coordinates (hg19) chr13:48340741-48341233  UCSC
Strand -
Parental Sequence NM_000990.5
Parental seq. overlap 416 bp
Parental seq. overlap (%) 9.2%
Genomic Region Intergenic
Retrocopy Summary RPL27AP8, located on chr13:47766606-47767098, is a retrocopy of the parental gene RPL27A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPL27A
Full Name ribosomal protein L27a
Also known as L27A
Coordinate chr11:8682792-8689872
Strand +
Gene summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RPL27AP6
Bonobo Pan paniscus RPL27AP7
Gorilla Gorilla gorilla RPL27AP6
Gibbon Nomascus leucogenys RPL27AP3
Green monkey Chlorocebus sabaeus RPL27AP2
Rhesus Macaca mulatta RPL27AP9
Baboon Papio anubis RPL27AP7
Golden snub-nosed monkey Rhinopithecus roxellana RPL27AP9
Marmoset Callithrix jacchus RPL27AP2
Orangutan Pongo abelii Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.10.2
log10(TPM+1)

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse - (ARCHS4)

Related Sequence

>RPL27AP8
ACATACCATTCAGGCTGAGGAAGACCCAGAAACTTCTGGGCCATGTAAGCCACAGCCACAGCCTCATCAGCAAGCACCAAAAGCACTCCGGAGGCAGGAGTAATACTGGTGGCAAGCATCACCACAGGATCAACTTTGACAAACCTCACCTAGGTTCCTTTGGGAAAGTTGGTATAAGGGTTACCACTTAAAGAGGAACCAGAGCTCCTGCTCAAATGCCAACCCTGATAAATTGTGGACTTTGGTCAGTGTACAGACACAGGTGAATGCTGCTAAAGACAAAACTGGAGCTGCTCCCACCATTGATGTGGTGTGATCAGGCTACTACAAAGTTCTGGAGTTCTGGGAAACGGAAATCTACCAAAGCAACCTGTCATCATGAAGGCCAAATTCTTCAGCAGAAGAGCTGAGGAGAGGATTAAGGGTGTTGGAGGTGGGGCTTGAGTCCTGGTGGTATGAAACCACATGGATGGAGGTTTGTTAAATGCTAACA
>NM_000990.5
CTTTTTCGTCTGGGCTGCCAACATGCCATCCAGACTGAGGAAGACCCGGAAACTTAGGGGCCACGTGAGCCACGGCCACGGCCGCATAGGCAAGCACCGGAAGCACCCCGGCGGCCGCGGTAATGCTGGTGGTCTGCATCACCACCGGATCAACTTCGACAAATACCACCCAGGCTACTTTGGGAAAGTTGGTATGAAGCATTACCACTTAAAGAGGAACCAGAGCTTCTGCCCAACTGTCAACCTTGACAAATTGTGGACTTTGGTCAGTGAACAGACACGGGTGAATGCTGCTAAAAACAAGACTGGGGCTGCTCCCATCATTGATGTGGTGCGATCGGGCTACTACAAAGTTCTGGGAAAGGGAAAGCTCCCAAAGCAGCCTGTCATCGTGAAGGCCAAATTCTTCAGCAGAAGAGCTGAGGAGAAGATTAAGAGTGTTGGGGGGGCCTGTGTCCTGGTGGCTTGAAGCCACATGGAGGGAGTTTCATTAAATGCTAACTACTTTTTCCTTGTGGTGTGAGTGTAGGTTCTTCAGTGGCACCTCTACATCCTGTGTGCATTGGGAGCCCAGGTTCTAGTACTTAGGGTATGAAGACATGGGGTCCTCTCCTGACTTCCCTCAAATATATGGTAAACGTAAGACCAACACAGACGTTGGCCAGTTAAACATTTCTGTTTATAAAGTCAGAATAATACCTGTTGATCACTGAAAGGCCTGCATGTATTGTACTCTGAATTTTACAGTGAATGAGAGAATGTACCCTAATTGTTCAACAGGGCTCAAAAGGAAAGATTCCATTTTGATGGGTCACATTCTAAAGAGGGGCAGTGTGATAGGAATGAGATGGTCCTTTAGGACTTAAGTTCTCAGCCCAAGGTTTTTCCACGTGGCCCCCTCATCttttttttttttttaaacggagtctctcttgccaggctggagtgcagtggcacgatctcggctcactgcagcctccgcctcccaggttaagcgattctcctgcctcagcttcctgactaactgggattacaggcgcccaccaccatgcccagctaatttttgtattttcagtagagatggggtttcaccatgttggccatgctggtctctaactcctaacctcaagtgatctgcccacatcggcctccaaaagttctgggattatagtgtgagccactgcgcccggccATGGCTCCTTAATCTTGatccaaattattgttacatccagaatgtgatgaatcaaaatctcgagatgggggtccagcaatctgaaatttcagtatgccAGGGCTTTTCTGTATGTCAAAGTGGGTTTGAAATAGTTAATTTTTCTTCTAGTCTGAAATGTATCGGGAAAATTTGGAAATCCTGAAGGCTGGAAATTGAAATAAGTTTTTCTAGGATTTGTGTCTCTTGCTATTGGAAAACTGATGGTGACCAATTCATGTTTACAAATAAGATCCTCATAGATCTCGGTAAATTATAATTTGCTACAGTTTTATGGTTCTTCCTGTGATTTTGAGCTTTTTTTGACCCAAAATAATACAGTCTAAAACTATAGACAAATAAGATGGCACTTAGACTCCTGGGTTTTAGTTAGTGGAGGTTTCCTTAGTGCACTGTGGGGTCATAATAAGCCGAGAACCATGGCTGTCTATGGGACACATCTGTCAGGACAACCTTTAGAGGATGTTGGGGATCAAATAGAAGGCACAGAGAAGCACTGAATTGGCTTACATAAGAATAGGCTAGAATTACAAGTAGTGAAACCTCGATTCAGCTGGACAATTTTAAACAAATGTATCATTTGGCTTGTATCTTCTGTTGTGCTGGAGAAGTTAGAAATAAGGGCTCtccagaccagcctgaccaacctggagaaaccttgtctctactaaatacacaaaattagccaggcgtggtggcacatgcctgtaatcccagctactttggaggctgagccaggagaatctccaggaggcggaggttgctgtgagccgagatcgtgccattgcactccagcttgggcaacaagagtgaaactctgtcCACCCCCCCCAAAAAAAGTAAGGGCTCTCCATTAGGGCCCATAGAGGACTTGTAATATGGAACCTGAATCCAAGGATCCCACAATAAGTGGTCAGTAGTTCATGATGAATTAAAAGACTCAATATTTGGTCTTCACCCAATACCTGTGTGActtttagtcctaatttcctcatctttaaaatttcagtgaaagtgcctacctgaggattgtgtagattaaaatggaaaccgtgcacttaattttttgttttgttttgagacggagtctcgctctgtcgcccaggctggagtgcagtggtgcgatctcagatcactgcaagctccgcctcctaggttcagaccattctcctgcctcagcttcccaagtagctgggactacaggcgcccgccactgcgcccggctaattttttgcatttttagtagagacagggtttcaccgtgttagccaggatggtctcgatctcctgatctgcccgcctcagcctcccaaagtgctgggattacaggcatgagccaccgcgcccggccCAGGCACTTAATTTTTGTGTTTGACTTAGTAACTTAAGTGCAAACTATTACGGGAGCAGATGGAGTCAATTGGCCTTCATGTGATTGTCAGTGGGAAATTGGTCCAAGCAGAGGGAATACTGGTTCAGGAAACTGGTTTGGGAAGGTTAGGCAAACGGGAAGTGCTATGGTGGAGAGAAAGATTACTCTGGCCGGGCTGTAAAGGACGGCTACAATGGGAGGCTGAAGGCAGAACCAAGAAAATGGGAGTGAGTATGGAAAAGGTACGATTCAGACGGCATAATGGACGGGACTTGGAGACTGAATTGTAGTGGGCCGACCACAAAATGATAAGGCATGGAAGGAAGTAGAGTTTGGGGGGAAGGATCCCTAGTCCCTTAATGGCTACCTTCTTCCCCAGGAGTTGTTAGGCCATCCGATCCCCTGGCCTGGGAAAGAAACACTGATTTCGTTGCTGGCTTGTTCACTCACCAGAAGCTACAGCTACTAACAGTTCTAAAAACTGTTTCATGTGATGAGGAACAGACGAAAATAGTTTTGAGCCCTAAGTCCGCCGATTCCAGTGCTTTCTTGAACCCGCATTTACTAAAATATTTTCATGACTGCCAAGCTTTGAATAGCCTGCTGTGTTCATGGAGGCTCATACTGGCGATCTCTAGTGGCTGGCTAAAGCTTGAATTGCAAAAGATCTAATTTCTGGTCTAATGTAtatatgccttaaatatagttgcgttcaaacgtgggagctgcaggtgcaacttgattttatgacaaatggctgccacataatttgcacaagcagtgctcgtcaagggcagctaaatcaggcgagctttcaatcaaaataaatGTACTACTAAACCCTACTTAGCGGCTAACTAGCCCAAGAGCAGACAGCCCACGGACGGACTGCAAGTCGGAAGCGCGGGCGGAAGCTGTGCAGCGCCCACCTGGTGGCTCCATCGGCCGCGTTCATCAGTCAGCACGACCCGACCTCAGTGGCGTCCTCACAACACAGACCGGACCTTGGGTCTTACCCCGGCACCTGAGAACCACTTCCGGTGAGTAGCTTCTACTTCCGGAGACGATGACTCCCCCGCGTCCCAGACCGGAAGAAGCCCGGCGGAGACCGGCCTCGCTCGGCCACTTCCGGCAAGGGCGGAGCCGGCCAGTGGTGCGCGAGCGCAGATAACTCCCCTGGAGAGGCGGGATGTTCAACTCCACCCCTGGTCCTTGGGCGGCCGTGGGTCCCCTTCGAAGCGGAGGAATGGCCAACCTCGCCGCACTTCGAGCCCCTTTAGGGTGCGTTTAAGAACAGTGGGCGTGGCCTTTACGTAAATCTTCGAGATGGGAACCTCCAGAATTTGTCTCAATTGTCTAAAAGGTAATGAGCGTCAGCGACATTCAAGGGCACTTTGGGCTAAAAAAGAAAGTGCTTGTACACGGATGGAAATATTCTAGAAGAACATAAAAGGAATTTCCTCTTAGGAGGTTAGGGAAATGAGCACGAAGTATGTTTTGGTGCAGTTTTTTGTTCAACCCAATGCGTATTTTCATATTGAGAGGCAATATAAATGGAGCGAAAGTATCTTGAGAAAAAAAAAAAAACTACCAGAACTTGCCGTTGCTGAAAAGTAATATTTTCTCTTTCGAGAGTTTTCATGGCCTTTTAAATTACACCCCCACCTCCACAGGCAAATAAATTTGTTTTGGAATGCATACCACATCATCTGGCTCTAGAAACGTATTTTGTGTAGCTCCCCTAGCAAGAATATAGGTTAAAGCGTAAATTTAATTCCTGGCTCTATTTTACATCCCAATTTTTATTTTCCTCTCATTCCCACTTTACGTTGTTTCAAATAACCTAGTTTGTGTATCCCTGTAAGTCATTTTGGTATAAAGTAGGTTATAAGTGTACATGCGAAAAGATGTTTTTAACAAAAATGTAACTGA

Publications

PMID - Link Title