| Retrocopy Name | TMEM185AP1 |
|
| Species | Homo sapiens | |
| Coordinates (hg38) | chr2:120221924-120222983 UCSC | |
| Coordinates (T2T) | chr2:120656684-120657743 UCSC | |
| Coordinates (hg19) | chr2:120979500-120980559 UCSC | |
| Strand | - | |
| Parental Sequence | NM_032508.4 | |
| Parental seq. overlap | 853 bp | |
| Parental seq. overlap (%) | 31.4% | |
| Genomic Region |
Intergenic |
|
| Retrocopy Summary | TMEM185AP1, located on chr2:120221924-120222983, is a retrocopy of the parental gene TMEM185A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes. |
| Gene Name | TMEM185A |
| Full Name | transmembrane protein 185A |
| Also known as | CXorf13|FAM11A|FRAXF|ee3 |
| Coordinate | chrX:149596556-149631792 |
| Strand | - |
| Gene summary | The protein encoded by this gene is predicted to be a transmembrane protein. This gene is best known for localizing to the CpG island of the fragile site FRAXF. The 5' untranslated region of this gene contains a CGG trinucleotide repeat sequence that normally consists of 7-40 tandem CGG repeats but which can expand to greater than 300 repeats. Methylation of the CpG island leads to transcriptional silencing of this gene, but neither the silencing nor an expanded repeat region appear to manifest itself in a clear phenotypic manner. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Aug 2013] |
| >TMEM185AP1 |
| CTCCGCCATGAACCCCAGGGGCCTGTTCCAGGACTTCAACCCCAGTAAGTTTCTCATCTACACCTGCCTGCTGCTCTTCTCGGTGCTGCTGCCCCTCCGCCTGGACGGCATCATCCAATGGAGCTACTGGGCCGTCTTTGCCCCCATATGGCTGTGGAAGCTTCTAGTCGTCGCAGGCGCCTCCGTGGGCGCGGGCGTTTGGGCCCGCAACCCTCGCTACCGCACCGAGGGAGAGGCCTGTGTGGAGTTCAAAGCCATGCTGATCGCTGTGGGCATCCACCTGCTGCTGCTCATGTTCGAAGTCCTGGTCTGCGACAGGGTGGAGAGGGGCACCCACTTCTGGCTGCTGGTCTTCATGCCTCTCTTCTTCGTGTCCCCCGTGTCCGTGGCTGCCTGCGTCTGGGGCTTTCGACACGATAGGTCGCTGGAGCTGGAGATCCTGTGCTCGGTCAACATCCTGCAGTTCATCTTCATCGCCCTAAAGCTGGACAGGATTATTCACTGGCCGTGGCTGGTGGTGTTTGTGCCCCTGTGGATCCTCATGTCGTTCCTTTGCCTGGTCGTCCTCTATTACATCGTCTGGTCCCTCCTGTTCCTGCGGTCCCTGGATGTGGTTGCCGAGCAGCGGAGAACACACGTGACCATGGCTATCAGTTGGATAACGATTGTCGTGCCTCTGCTCACTTTTGAGGTCCTGCTGGTTCACAGATTGGATGGCCACAATACATTCTCCTACGTCTCCATATTTGTCCCCCTTTGGCTTTCCTTACTAACTTTAATGGCCACAACATTTAGGCGAAAGGGGGGCAATCATTGGTGGTTTGGCATTCGCAGAGACTTCTGTCAGTTTCTGCTTGAAATTTTCCCATTTTTAAGAGAATATGGGAACATTTCATATGATCTCCATCACGAAGATAGTGAAGATGCTGAAGAAACATCAGTTCCAGAAGCTCCGAAAATTGCTCCAATATTTGGAAAGAAGGCCAGAGTAGTTATAACCCAGAGCCCTGGGAAATACGTTCCCCCCCCTCCCAAGTTAAATATTGATATGCCAGATTAA |
| >NM_032508.4 |
| AGGTTTCTCCGggcggcggcggcggcggcggcggcggcggcggcggcggcggcggcgacggcgacggcgacggcagcggggacggcagcAGTAGCGGGAGCAGCAGCGTGGACGCGGCTGGCGCTGGCGCCATGAACCCGCTGTAAGGCGCAGGCTGTGCAGCACGGGGTGCGGGGGAGGAGGAGGAGGACGCCGCGGTGAAGTTCTCCGCCATGAACCTGAGGGGCCTCTTCCAGGACTTCAACCCGAGTAAATTCCTCATCTATGCCTGTCTGCTGCTGTTCTCTGTGCTGCTGGCCCTTCGTTTGGATGGCATCATACAGTGGAGTTACTGGGCTGTCTTTGCTCCAATATGGCTGTGGAAGTTAATGGTCATTGTTGGAGCCTCAGTTGGAACTGGAGTCTGGGCACGAAATCCTCAATATCGAGCAGAAGGAGAAACGTGTGTGGAGTTTAAAGCCATGTTGATTGCAGTGGGCATCCACTTGCTCTTGTTGATGTTTGAAGTTCTGGTCTGTGACAGAATCGAGAGAGGAAGCCATTTCTGGCTCCTGGTCTTCATGCCGCTGTTCTTTGTTTCCCCGGTGTCTGTTGCAGCTTGCGTTTGGGGCTTTCGACATGACAGGTCACTAGAGTTAGAAATCCTGTGTTCTGTCAACATTCTCCAGTTTATATTCATTGCCTTAAGACTGGACAAGATCATCCACTGGCCCTGGCTTGTTGTGTGTGTCCCGCTGTGGATTCTCATGTCCTTTCTGTGCCTGGTGGTCCTCTACTACATTGTGTGGTCCGTCTTGTTCTTGCGCTCTATGGATGTGATTGCGGAGCAGCGCAGGACACACATAACCATGGCCCTGAGCTGGATGACCATCGTCGTGCCCCTTCTTACATTTGAGATTCTGCTGGTTCACAAACTGGATGGCCACAACGCCTTCTCCTGCATCCCGATCTTTGTCCCCCTTTGGCTCTCGTTGATCACGCTGATGGCAACCACATTTGGACAGAAGGGAGGAAACCACTGGTGGTTTGGTATCCGCAAAGATTTCTGTCAGTTTCTGCTTGAAATCTTCCCATTTCTACGAGAATATGGAAACATTTCCTATGATCTCCATCACGAAGATAATGAAGAAACCGAAGAGACCCCAGTTCCGGAGCCCCCTAAAATCGCACCCATGTTTCGAAAGAAGGCCAGGGTGGTCATTACCCAGAGCCCTGGGAAGTATGTGCTCCCACCTCCCAAATTAAATATCGAAATGCCAGATTAGATGCCACTTCCGGGGACAGAGCTTAAGTGGACTGGGACGCACTCTCTCCGCCTTCCTCTGCCCCCTCGTTCACCCCGCAGACCAGAACCAGTACTGGAGCTGGGTCTCCAGGTACGTCCATCTCATGCCTTGTTTGCATCCAGCGCCTATCAGCCACTCACCACGACGGGACGCGGAAGTGGCAGGTGACGGGGGTGTGTGCCAGCAGATGCGGATGCCAGGAAGAGTGTGAGAACAGGGGTGGGATTACCGTCTGTCTGGGAGGGGCTCCAGGTACCCCTCTTCCCCGTCAGACCCACTGGGAGATGGCTGCTTGCCAGGCCCCCAGAAGGAACATCTGTCTATACGGTGCTGAAATCCCAATCAAAAGTATTGTTTAGAAATGTATTTCTCCACAGGGCTGACCTCCTGCAGCTCGCTGAGCACTCCCAGGTCCTCAGCACTCCCAGGTCGTGGCTGGGGCAGTCAGTAGGAACTGTAACTATGTCTCTGATGCACCACGTGTTTAGACACAGCACAGTCCTTTTTTCTGTTCCTACTGTGGAAGTAGTTTCTCTTTGGGCATGCTGACAGCAGTTTTTCATAGCCTCACGGATGAGCCCTTTCTACGGGAGTGACTCCATGCTTGTATACAGAGTATTTATACAAATGTTTTAGCATCTTCATATGCGGTGTTAACCCCTAGTTCTGTACAGCATATTCTGTTCAAGTATTTTTTTACAAGCTTGTGCTGTAGGCACATGCCTTCTGCTGCAGAAGTGGACGCCCGTGGCACACTCCCCCCCCCCCCGTGGGGTGCCACGCCTTCATGGGACATTGCCACTTCTGCCCTGGAACTCGTGCAGGTACGTAGTAGCTGCTACTGCCACAACGGCAACACCAAGCAAGAGATGGTCCATGCTTTTCTGACGTTCTCAGAATAGTGGCTAGCTTCAAACCTGACAAGCGCTGCTTGAAGCCGGAACACTAGAGAATGTTGCTGAGAGCAGAAACGGCCACGCGGGTCACGACTATGCGTGGGAAAGTCTCAAGCTTCCCTCCTGCCAGCAACAAGAAGGCTTTGGAGTAGGCATGATGTTTTCACGTGTGCGTGCCGTTTCTCCAAGCACTGCAGGTTCCACCGTGTGTCAGAGGCTGCAAGTTTAACATCCTCCTGCCTGAAAACAAATAGGTCCTTTGCTGAAAAGAGGGTAAAAAAAGAGCTTTGATCTTCTCAGCCAGGAGAAGAGGGTGGTGTTTTCACGCGGGCAACTGCTCGCCGGCCTACATGGGGTTAATTCAAGTCTGCTGCGAGCACGACTCCGCCCTTGGCACTGGCCTCCAGCAAGCCCTGTTCTCTTTGGGGTACAGGGGAACGGGATGGTTTAGACTTTCCTGCTCAGTGTGTAAAAAATGTAGCTAAAGCCACTATTTTTGCTCTCCTTAAGCTGTTCAATAAACCGGTTCCTCATTTTA |
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