Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RPS6P12
Plot displaying the genomic locations of a retrocopy (in chr9) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr9:82744241-82744836  UCSC
Coordinates (T2T) chr9:94893817-94894412  UCSC
Coordinates (hg19) chr9:85359156-85359751  UCSC
Strand -
Parental Sequence NM_001010.3
Parental seq. overlap 483 bp
Parental seq. overlap (%) 35%
Genomic Region Intergenic
Retrocopy Summary RPS6P12, located on chr9:82744241-82744836, is a retrocopy of the parental gene RPS6. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPS6
Full Name ribosomal protein S6
Also known as S6
Coordinate chr9:19375715-19380236
Strand -
Gene summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Bonobo Pan paniscus RPS6P8
Gorilla Gorilla gorilla LOC101131142P9
Orangutan Pongo abelii RPS6P9
Gibbon Nomascus leucogenys RPS6P1
Rhesus Macaca mulatta LOC712274P19
Golden snub-nosed monkey Rhinopithecus roxellana RPS6P24
Dolphin Tursiops truncatus RPS6P8
Horse Equus caballus RPS6P6
Dog Canis familiaris RPS6P2
Panda Ailuropoda melanoleuca RPS6P30
Greater mouse-eared bat Myotis myotis RPS6P39
Egyptian rousette Rousettus aegyptiacus RPS6P10
Chimpanzee Pan troglodytes Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPS6P12
CTCTTTTTCGTGGCACCTTGGGGGTGATCAGCTGTTTCAGAAGGAAGCTGCACATTTCCTTCCCAGCTACTGGCTGCCAGAAGTTCATTGAAGTAGATAATGACAGCAAACCTCATACCTTTGTGAGAAGCGTATGGCCACAGAAATTGCTGCTGACACTCTGAGTGAAGAATAGAAGGGTTATGTGTACAAAATCAGTAGTGGGAAAAAACAAACAAGTTTTCCTCATGAAGCAGGGTACCTTGACCATGGCCATGTCTGCCTGCTGCTGAGCAGGGGCATTCCTGTAATAGACCAAGGAGGACTTGGGAAAGGAGGTGCTAATCTGTTCTGGGTTTATTGTGGACGCCAATCTGTGTGTTCTCACTTTGGTTATTTTTTTTTTTTTTAAGGAGGAAGATATTCTTGGACTGCCTTACTACTGTGCCTCGTCACCTGGGGCCTGAGAGAGCTAGCGGTGTCTGCAAATTTTCCAACTCTCTAAAGAAGATGATGTCCACCAGTTTGCTAAGAGAAAGCCCCTGAATAAAGACAGTAAGAAACTCAGGACCAAATTGCTAGAGATTCAGTGTCTTGTTACTCAGCATGTCCTGCAA
>NM_001010.3
CTCTTTTCCGTGGCGCCTCGGAGGCGTTCAGCTGCTTCAAGATGAAGCTGAACATCTCCTTCCCAGCCACTGGCTGCCAGAAACTCATTGAAGTGGACGATGAACGCAAACTTCGTACTTTCTATGAGAAGCGTATGGCCACAGAAGTTGCTGCTGACGCTCTGGGTGAAGAATGGAAGGGTTATGTGGTCCGAATCAGTGGTGGGAACGACAAACAAGGTTTCCCCATGAAGCAGGGTGTCTTGACCCATGGCCGTGTCCGCCTGCTACTGAGTAAGGGGCATTCCTGTTACAGACCAAGGAGAACTGGAGAAAGAAAGAGAAAATCAGTTCGTGGTTGCATTGTGGATGCAAATCTGAGCGTTCTCAACTTGGTTATTGTAAAAAAAGGAGAGAAGGATATTCCTGGACTGACTGATACTACAGTGCCTCGCCGCCTGGGCCCCAAAAGAGCTAGCAGAATCCGCAAACTTTTCAATCTCTCTAAAGAAGATGATGTCCGCCAGTATGTTGTAAGAAAGCCCTTAAATAAAGAAGGTAAGAAACCTAGGACCAAAGCACCCAAGATTCAGCGTCTTGTTACTCCACGTGTCCTGCAGCACAAACGGCGGCGTATTGCTCTGAAGAAGCAGCGTACCAAGAAAAATAAAGAAGAGGCTGCAGAATATGCTAAACTTTTGGCCAAGAGAATGAAGGAGGCTAAGGAGAAGCGCCAGGAACAAATTGCGAAGAGACGCAGACTTTCCTCTCTGCGAGCTTCTACTTCTAAGTCTGAATCCAGTCAGAAATAAGATTTTTTGAGTAACAAATAAATAAGATCAGACTCTGATCTCTGTTGACTTTTCATTGCTGATAGAAAACTACATAAATGAAGAGAGGGAAAGTTAGGTCATAGAAAATGGGGATATGTATATATGGTATTCCAATGGTGGATAAAGTCAGACCTATTGTGTGTGGTAGTGGAAGACAAGGTCAGTGTACAGGGGTTCCTTTCAGGGGATGGGTGGCACAGGAAGGGATTCTGAGCATAAGACACCTGCCTCTTCAGAATGGCATGGAACTTAGGGGAAATGATGAGGACTATTAATCTTTTTTATATAGTTTATTTTTGAGGAATATAGCTCTTTAAAGCACTATACACAATTTAATACATGAAAATTGACCTTGTGAAGATGAACATGTCTTTTTTAAAAGGTAACTTTTAAGGCATAGTTTTAGTGGATACCTAGTTTTAGTGGATACCATCCACTAAATGGTTTTTAAGCCATTTCAAATTTGTTTTAACAAAGCTTTTCAACTCCAGTGAATTGTTAGGCTGTTCACACACTGAAAAGGAAATGACTAAAAACATTCTTGGATCAGTGAAAAA

Publications

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