Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name RPSAP62
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chrX:53323128-53323843  UCSC
Coordinates (T2T) chrX:52609391-52610106  UCSC
Coordinates (hg19) chrX:53352325-53353040  UCSC
Strand +
Parental Sequence NM_002295.6
Parental seq. overlap 607 bp
Parental seq. overlap (%) 53.2%
Genomic Region Intergenic
Retrocopy Summary RPSAP62, located on chrX:53323128-53323843, is a retrocopy of the parental gene RPSA. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPSA
Full Name ribosomal protein SA
Also known as 37LRP|67LR|ICAS|LAMBR|LAMR1|LBP|LBP/p40|LRP|LRP/LR|NEM/1CHD4|SA|lamR|p40
Coordinate chr3:39406720-39412542
Strand +
Gene summary Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RPSAP65
Bonobo Pan paniscus RPSAP66
Gorilla Gorilla gorilla RPSAP65
Orangutan Pongo abelii RPSAP67
Gibbon Nomascus leucogenys RPSAP66
Green monkey Chlorocebus sabaeus RPSAP56
Crab-eating macaque Macaca fascicularis RPSAP62
Rhesus Macaca mulatta RPSAP63
Baboon Papio anubis RPSAP57
Golden snub-nosed monkey Rhinopithecus roxellana RPSAP34
Marmoset Callithrix jacchus RPSAP70
Mouse lemur Microcebus murinus RPSAP43
Pig Sus scrofa RPSAP27
Dolphin Tursiops truncatus RPSAP39
Horse Equus caballus RPSAP37
Dog Canis familiaris RPSAP48
Panda Ailuropoda melanoleuca RPSAP46
Cat Felis catus RPSAP54
Velvety free-tailed bat Molossus molossus RPSAP10
Greater horseshoe bat Rhinolophus ferrumequinum RPSAP2
Egyptian rousette Rousettus aegyptiacus RPSAP22
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPSAP62
CATTGTTGCCATTGAAAACCAGACTGATGCTAGTATTATATCTTCCAGGAATACTGGCCAGTGGGCTGTGCTAAAGTTTGCTGTTTCCACTGGGGCCACTCTTATTGCTGGGCACTTCACTCCTGGAACTTTCACTAATCAGATCCAGGCAGCCTTCCAGGAGCCACGTCTGCTGGTGGTTACTGATCCCAGGGCTGACCACTAACCTCTCACAGAGGCATCTTATATTAACTTGCCTATCATTGCTCTGGGTCACACAGAGTCTCCCCTGCACTGTGTGGACACTGCCATCCCATGCAACAACCCAGGAGTTCCCTCAGGGGGTCTAGTGTAATGGATGCTGGCCCAGGAGGTTCTGCACGTGCGTTGTACCACCTCCCGTGAACACCCATGGGAGTTATGCCTGATCTCTATTTCTGCAGAGATCCTGAAAAGATTGAAAACGAAGAGCAGGCTGCTGGAGAAAAGGCTGTGACCAAGGAGGAACTTCAGGGTGAATGGACTGCGCCAGCTCCTGAGTCTACTGCTATTCAACCTGAGGGTACAGACTGGTCTGAAGGCATGCAGGTGCCCTTTGTACCTATTCAATAATTCTCTACTCAAGTTTGGAGCACTCAGCCTGCCACTGGAGGCTGGTCTGTAGCAGTCACTCTCAGATAGCTGACTGGATAGGAATAACCACTGAGTGGTCTTAAGCTATTCTTCCACAGGCTCTT
>NM_002295.6
CTTTTCCGTGCTACCTGCAGAGGGGTCCATACGGCGTTGTTCTGGATTCCCGTCGTAACTTAAAGGGAAATTTTCACAATGTCCggagcccttgatgtcctgcaaatgaaggagGAGGATGTCCTTAAGTTCCTTGCAGCAGGAACCCACTTAGGTGGCACCAATCTTGACTTCCAGATGGAACAGTACATCTATAAAAGGAAAAGTGATGGCATCTATATCATAAATCTCAAGAGGACCTGGGAGAAGCTTCTGCTGGCAGCTCGTGCAATTGTTGCCATTGAAAACCCTGCTGATGTCAGTGTTATATCCTCCAGGAATACTGGCCAGAGGGCTGTGCTGAAGTTTGCTGCTGCCACTGGAGCCACTCCAATTGCTGGCCGCTTCACTCCTGGAACCTTCACTAACCAGATCCAGGCAGCCTTCCGGGAGCCACGGCTTCTTGTGGTTACTGACCCCAGGGCTGACCACCAGCCTCTCACGGAGGCATCTTATGTTAACCTACCTACCATTGCGCTGTGTAACACAGATTCTCCTCTGCGCTATGTGGACATTGCCATCCCATGCAACAACAAGGGAGCTCACTCAGTGGGTTTGATGTGGTGGATGCTGGCTCGGGAAGTTCTGCGCATGCGTGGCACCATTTCCCGTGAACACCCATGGGAGGTCATGCCTGATCTGTACTTCTACAGAGATCCTGAAGAGATTGAAAAAGAAGAGCAGGCTGCTGCTGAGAAGGCAGTGACCAAGGAGGAATTTCAGGGTGAATGGACTGCTCCCGCTCCTGAGTTCACTGCTACTCAGCCTGAGGTTGCAGACTGGTCTGAAGGTGTACAGGTGCCCTCTGTGCCTATTCAGCAATTCCCTACTGAAGACTGGAGCGCTCAGCCTGCCACGGAAGACTGGTCTGCAGCTCCCACTGCTCAGGCCACTGAATGGGTAGGAGCAACCACTGACTGGTCTTAAGCTGTTCTTGCATAGGCTCTTAAGCAGCATGGAAAAATGGTTGATGGAAAATAAACATCAGTTTCTAAAAGTTGTCTTCATTTAGTTTGCTTTTTACTCCAGATCAGAATACCTGGGATTGCATATCAAAGCATAATAATAAATACATGTCTCGACATGAGTTGTACTTCTAAA

Publications

PMID - Link Title