Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Summary

Retrocopy Name Acta1P1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Rattus norvegicus
Coordinates chr2:42829605-42830633  UCSC
Strand +
Parental Sequence NM_019212.2
Parental seq. overlap 816 bp
Parental seq. overlap (%) 56.7%
Genomic Region Intergenic
Retrocopy Summary Acta1P1, located on chr2:42829605-42830633, is a retrocopy of the parental gene Acta1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Acta1
Full Name actin, alpha 1, skeletal muscle
Also known as -
Coordinate chr19:56674072-56677084
Strand -
Gene summary Predicted to enable ATP binding activity. Involved in several processes, including response to lithium ion; response to steroid hormone; and skeletal muscle fiber adaptation. Predicted to be located in several cellular components, including filopodium; lamellipodium; and sarcomere. Predicted to be part of dynactin complex. Predicted to be active in actin filament; stress fiber; and striated muscle thin filament. Human ortholog(s) of this gene implicated in congenital fiber-type disproportion and nemaline myopathy 3. Orthologous to human ACTA1 (actin alpha 1, skeletal muscle). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens ACTG2P1
Bonobo Pan paniscus ACTG2P3
Gorilla Gorilla gorilla LOC101127752P18
Orangutan Pongo abelii ACTG2P1
Gibbon Nomascus leucogenys ACTG2P1
Green monkey Chlorocebus sabaeus ACTG1P5
Crab-eating macaque Macaca fascicularis ACTBP8
Rhesus Macaca mulatta ACTBP8
Baboon Papio anubis ACTG2P1
Golden snub-nosed monkey Rhinopithecus roxellana ACTBP6
Marmoset Callithrix jacchus ACTG1P3
Mouse lemur Microcebus murinus ACTG1P2
Mouse Mus musculus Actg2P1
Chinese hamster Cricetulus griseus Actb_1P1
Rabbit Oryctolagus cuniculus ACTG2P1
Pig Sus scrofa ACTG1P5
Cow Bos taurus ACTG1P3
Sheep Ovis aries ACTBP3
Horse Equus caballus ACTG1P2
Dog Canis familiaris ACTG1P2
Panda Ailuropoda melanoleuca ACTG2P1
Cat Felis catus ACTG2P1
Pale spear-nosed bat Phyllostomus discolor ACTA2P1
Velvety free-tailed bat Molossus molossus ACTA2P1
Greater horseshoe bat Rhinolophus ferrumequinum LOC01822P5
Egyptian rousette Rousettus aegyptiacus ACTG2P1
Sloth Choloepus didactylus ACTBP11
Chimpanzee Pan troglodytes Without Homology
Dolphin Tursiops truncatus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Acta1P1
TGATGACGCCCCCCGTGCTGTGTTCCCCTCCATGGTAGGGCGTCCACGACACCAAGGGGTCATGGTGGGCATGGGCCAGAAGGACTGTTATGTGGGAGATGAGGCCCAGAGCAAGAGAGGCATCTTGACCCTGAAGTATCCCATTGAACATGGAGTCGTCACCAACTGGGATGACATGGAGAAGATCTGGTACCACACTTTCTACAATGAGCTCCGTGTAGCACCGGATGAGCATCCTATTCTTCTCACCGAGGCACCCCTCAACCCCAAAATCAACCGGGAGAAGATGACTCAGATAATGTTTGAGGCTTTCAACACACCTGCCATGTATGTAGCTATCCAAGCCGTACTGTCCCTCTATGCCTCGGGAAGGACGACAGGTAACGTGATGGATTCTGGGGATGGCGTCACTCACACTGTGCCTATCTATGAAGGCTATGCTCTGCCCCATGGCATTCTACGACTAGATCTGGCAGGCAGAGACCTGACTGATTACCTCATGAAGATCCTGACAGAACGAGGTTATAACTTCACCACCACAGCTGAGAGGGAGATCGTGCGGGATGTCAAAGAAAAGCTGTGCTATGTGGCCCTGGACTTTGAGCAGGAGATGGTCACTGCAGCTGCTTCATCCTCACTTGAAAGAAGCTATGAGCTCCCTGATGGGCAGGTGATCACCATTGGGAACGAACGTTTTCGATGCCCAGAAGCCATTTTCCAGCCTTCCTTTCTAGGTATTGAATCCAGAGGGATCCATGAGACAACCTTCAACTCCATCATGAAGTGTGATGTGGATATTCGCAAGGATTTATATGCCAACACTGTGCTGTCTGGAGGCAGCACCATGTACCCGGGCATTGCCGACAGGATGCAGAAGGAAATCGTAACCTTGGCACCAAGCACCATGAAAATTAAGATCATAGCTCCCCCAGAACGCAAGTATTCAGTTTGGATTGGGGGCTCCATCCTCGCCAGCCTATCCACATTCCAGCAGATGTGGATCAGTAAGCAGGAGTACGATGAAGCCGG
>NM_019212.2
TGAAGCCTCACTTCCTACCCTCGGCACCCAGGGCCAGAGTCAGAGCAGCAGAAACTAGACACCATGTGTGACGAGGACGAGACCACCGCTCTTGTGTGTGACAACGGCTCTGGCCTGGTGAAAGCTGGCTTTGCCGGGGATGATGCCCCCAGGGCTGTGTTCCCATCCATCGTGGGTCGGCCCCGTCACCAGGGTGTCATGGTCGGTATGGGTCAGAAGGATTCCTACGTGGGCGACGAGGCCCAGAGCAAGCGAGGTATCCTGACCCTGAAGTACCCCATTGAACACGGCATTATCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCCCCCGAGGAGCACCCGACCCTGCTCACTGAGGCCCCTTTGAACCCCAAAGCTAACCGGGAGAAGATGACTCAAATCATGTTTGAGACCTTCAACGTGCCTGCTATGTATGTGGCTATTCAGGCGGTGCTGTCTCTCTATGCCTCCGGCCGTACCACCGGCATCGTGTTGGATTCTGGGGACGGTGTCACCCACAACGTGCCCATCTATGAGGGTTATGCCCTGCCACACGCCATCATGCGTCTGGACCTGGCTGGTCGCGACCTTACTGACTACCTGATGAAAATCCTCACCGAGCGTGGCTATTCCTTCGTGACCACAGCTGAACGTGAGATTGTGCGCGACATCAAAGAGAAGCTGTGCTACGTGGCCCTGGACTTCGAGAATGAGATGGCCACCGCTGCCTCTTCCTCCTCCCTGGAAAAGAGCTATGAGCTGCCTGACGGGCAGGTCATCACCATCGGCAATGAGCGCTTCCGTTGCCCGGAGACGCTCTTCCAGCCTTCCTTTATCGGTATGGAGTCTGCGGGGATCCATGAGACCACCTACAACAGCATCATGAAGTGCGACATCGACATCAGGAAGGACCTGTACGCCAACAACGTCATGTCAGGGGGCACTACCATGTACCCCGGTATCGCTGACCGCATGCAGAAGGAGATCACAGCTCTGGCTCCCAGCACCATGAAGATCAAGATCATCGCCCCCCCTGAGCGCAAGTACTCAGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCACCAAGCAGGAGTACGACGAGGCCGGCCCCTCCATTGTGCACCGCAAATGCTTCTAGGCGCACCCGCGTCTGTGTACGCGCTCTCTCTCCTCAGGACGACAATCGACCATCGTGCTATGGTTGCAGGGTGGCCCCATCCTCCGCCGTGGCTCCATCGCCGCCACTGCAGCCGGCGCCTGTTTTTGACGTGTACATAGATTCACTCGTTTTACCTCATTTTGTTATTTTTCAAACAAAGCCCTGTGGAAGGAAATGGAAAACTTGAAGCATTAAAGCCAGCCATTCTGTTTTGCTCCAA

Publications

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