Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name LdhcP1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Rattus norvegicus
Coordinates chr1:46308396-46308550  UCSC
Strand -
Parental Sequence NM_017266.2
Parental seq. overlap 125 bp
Parental seq. overlap (%) 10.7%
Genomic Region Intergenic
Retrocopy Summary LdhcP1, located on chr1:46308396-46308550, is a retrocopy of the parental gene Ldhc. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Ldhc
Full Name lactate dehydrogenase C
Also known as Ldh3
Coordinate chr1:102914875-102931843
Strand +
Gene summary Predicted to enable L-lactate dehydrogenase activity. Predicted to be involved in carbohydrate metabolic process and carboxylic acid metabolic process. Predicted to act upstream of or within ATP biosynthetic process; flagellated sperm motility; and lactate metabolic process. Predicted to be located in cytoplasm and motile cilium. Orthologous to human LDHC (lactate dehydrogenase C). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens LDHAL6FP
Chimpanzee Pan troglodytes LDHAL6AP2
Bonobo Pan paniscus LDHAL6AP2
Orangutan Pongo abelii LDHAL6AP2
Gibbon Nomascus leucogenys LDHAL6AP1
Marmoset Callithrix jacchus LDHAL6AP4
Mouse lemur Microcebus murinus LDHAL6AP1
Chinese hamster Cricetulus griseus Ldha_1P3
Dolphin Tursiops truncatus LDHAP1
Dog Canis familiaris LDHAP1
Panda Ailuropoda melanoleuca LOC100474915P2
Cat Felis catus LDHAL6AP1
Greater horseshoe bat Rhinolophus ferrumequinum LDHAP2
Egyptian rousette Rousettus aegyptiacus LDHAP1
Gorilla Gorilla gorilla Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse Mus musculus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Horse Equus caballus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>LdhcP1
GTGTTATTGGAAGTGGCTGTAACCTAGATACAGCTCGTTTCCGTTACATGCTTGGGCAGAGGCTTGGGATCCACTCTGAAAGCTGTCATGGGTGGGTCCTTGGAGAGCATGGAGACTCAAGTGTCCCTGTGTGGAGTGGTGTAAACATCGCTGGT
>NM_017266.2
CCTGGGCCTAACGGTCATCCTTGTTTCTTAACTGCTGCGGGGTGTGTTTTCGACATCCTTTGAGGAAGTGGGCAGTGCCTTCATCCACCTGTGAAGGCTCAACATGTCCACTGTCAAGGAGCAGCTAATTCAGAACCTAGCTCCAGATGAAAAACAATCCCGGTGTAAGATCACTGTGGTCGGAGTTGGAAATGTGGGCATGGCGTGTGCCATTAGTATTTTACTGAAGGGTCTGGCTGATGAACTTgcccttgttgatgctgatgagaacaaactgaagggagaggcactggatcttctgcatggcagccttttcctcagcaCTCCAAAAATCGTCTTTGGAAAAGATTACAGTGTATCTGCCAACTCCAAACTGGTTATTATCACTGCTGGTGCAAGAATGGTGAGTGGAGAATCTCGTCTTGCCCTGCTCCAACGTAATGTCACTATCATGAAAGCCATCGTTCCCGGCGTAATCCAAAACAGTCCGGACTGTAAAATAATGATTGTCACAAACCCAGTCGATATTTTGACATACGTGGTTTGGAAGATAAGTGGCCTCCCTGTAAGCAGTGTGATTGGAAGTGGCTGTAACCTAGACTCCGCTCGTTTCCGTTACCTGATTGGAGAGAAGCTGGGTGTCAACCCTTCGAGCTGCCATGGCTGGGTTCTTGGAGAACATGGGGACTCCAGTGTGCCCATATGGAGTGGTGTGAACATTGCTGGCGTAACTCTGAAGTCACTGAACCCAGCAATAGGATCCGACTCCGATAAGGAACAGTGGAAAACCGTTCACAAGCAGGTGGTGGATGGTGGCTATGAGGTCCTTAACCTGAAGGGCTATACCTCTTGGGCCATTGCGCTGTCTGTGACTGATATCGCTGCATCAATCTTGAAGAATCTTAAGAGGGTGCATGCTGTTACTACGCTGGTTAAGGGCTTATATGGGATAAAGGAAGAAATCTTCCTCAGTATCCCGTGTGTCTTGGGACAAAGTGGCATCACAGACCTTGTGAAAGTCAACATGAACACCGAGGAGGAAGCTCTTTTTAAGAAGAGTTGCGACATACTCTGGAACATCCAGAAAGATCTGCAATTATAAAGTCTGCACCTTCGACTGTTTGATAACCACCATCATTCATAAATTCAATAAAAGTTTGGAAACCTAAAA

Publications

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