Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name LDHAL6FP
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:157299147-157299956  UCSC
Coordinates (T2T) chr6:158504924-158505733  UCSC
Coordinates (hg19) chr6:157720179-157720988  UCSC
Strand -
Parental Sequence NM_001144071.2
Parental seq. overlap 707 bp
Parental seq. overlap (%) 36%
Genomic Region Intragenic (TMEM242)
Retrocopy Summary LDHAL6FP, located on chr6:157299147-157299956, is a retrocopy of the parental gene LDHAL6A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name LDHAL6A
Full Name lactate dehydrogenase A like 6A
Also known as LDH6A
Coordinate chr11:18455856-18479601
Strand +
Gene summary Predicted to enable L-lactate dehydrogenase activity. Predicted to be involved in carbohydrate metabolic process and carboxylic acid metabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes LDHAL6AP2
Bonobo Pan paniscus LDHAL6AP2
Orangutan Pongo abelii LDHAL6AP2
Gibbon Nomascus leucogenys LDHAL6AP1
Green monkey Chlorocebus sabaeus LDHAL6AP5
Crab-eating macaque Macaca fascicularis LDHAL6AP1
Rhesus Macaca mulatta LDHAL6AP1
Baboon Papio anubis LDHAL6AP2
Golden snub-nosed monkey Rhinopithecus roxellana LDHAL6AP2
Marmoset Callithrix jacchus LDHAL6AP4
Mouse lemur Microcebus murinus LDHAL6AP1
Rat Rattus norvegicus LdhcP1
Chinese hamster Cricetulus griseus Ldha_1P3
Pig Sus scrofa LDHAP1
Cow Bos taurus LDHAP1
Dolphin Tursiops truncatus LDHAP1
Dog Canis familiaris LDHAP1
Panda Ailuropoda melanoleuca LOC100474915P2
Cat Felis catus LDHAL6AP1
Greater horseshoe bat Rhinolophus ferrumequinum LDHAP2
Egyptian rousette Rousettus aegyptiacus LDHAP1
Gorilla Gorilla gorilla Without Homology
Mouse Mus musculus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Sheep Ovis aries Without Homology
Horse Equus caballus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>LDHAL6FP
TCATCACAGTAAGGTCTCCATCATAGGAACTGGATCGGTGGGCATGGCCTGCGCTACCAGCATCTTATTAAAAGGCTTGAGTGATGAACTTGCCCTTGTGGATCTTGATGAAGGCAAACTGAAGGGTGAGACAATGGATCTTCAACATGGCAGCCCTTTCATGAAAACGCCAAATATTGTTTGTAGCAAAGATTACCTTGTCACAGCAAACTCCAGCCTAGTGATTATCACAGAAGGTGCACGTCAAGAAAAGGGAGAAACGCGCCTTAATTTAGTCCAGCGAAATGTGGCCATCTTCAAGTTAATGATTTCCGGTATTGTCCAGTACAGCCCCCTCTGCAAGCTGATTATTGTTTCCAATCCAGTGGATAACTTAACTTATGTAGCCTGGAAGTTGAGTGCATTTTCCAAAAACCGTGTTATTGGAAGCGGCTGTAATCTGGATACTGCTCGTTTTTGTTTCTTGTTTGGACAAAAGCTTGGTATCCACTCTGAAAACTGCCACGGATGGATCCTAGGAGAGCATGGAGACTCAAGTGTTCCTGTATGGAGTGGAGTGAACATAGCTGGTGTCGCTTTGAAGAATCTGAACTCTGATACAGGAACTGATAAAGATCCTGAACAATGGAAAAATGTCCACAAGTGATTGCTAGTGCCTATGAGATTATTAAAATGAAAGGTTATACTTCATGGGCCATTGGCCTATCTGTAGCTGATTTAACAGAAAGTATTTTGAAGAATCTTAGGAGAACACATCCAGTTTCCACCATCATTAGGGGTCTCTGTGGAATAGATGAAGAAGTATTCCTC
>NM_001144071.2
GCTTCCGGCCTCACACCTGCCAAGCATCACACCTGCCAAGCATCACACCTGCCAAGCATCACACCTGCCAAGCATCACACCTGCGATGCCTGCACGAGCTGGGTGCGGTCCGCGCAGCTGCAGTAAGGGGGCGACCCGGCGTCTGTTAGTCGGCGGTTCATCTCCTTCGTGCCTCGATGAGCTTTAACGCCATTTTCCTCCATTCTCTTTCTTCACCTCTTGAGTTTCCAAGATGGCAACTATCAAGAGTGAACTTATTAAGAATTTCGCGGAAGAGGAGGCCATTCATCACAATAAGATCTCCATTGTAGGAACTGGATCGGTTGGTGTGGCTTGTGCTATCAGCATCTTATTAAAAGGTTTGAGTGATGAACTTGTCCTTGTGGATGTTGATGAAGGCAAACTGAAGGGTGAGACAATGGATCTTCAACATGGCAGCCCTTTTATGAAAATGCCAAATATTGTCTCCAGCAAAGATTACCTGGTCACTGCAAACTCCAATCTAGTGATTATCACAGCAGGTGCACGCCAGAAAAAAGGAGAAACACGCCTTGATTTAGTCCAGCGAAATGTATCCATCTTTAAATTAATGATTCCCAATATTACCCAGTACAGTCCTCACTGCAAACTGCTTATTGTTACTAATCCAGTGGATATCTTAACTTATGTAGCCTGGAAGTTGAGTGGATTTCCCAAAAACCGTGTTATTGGAAGTGGTTGTAATCTGGACTCTGCTCGTTTTCGTTACTTTATTGGGCAAAGGCTTGGCATCCACTCTGAAAGCTGTCATGGGCTGATCCTTGGAGAGCATGGCGACTCAAGTGTTCCTGTGTGGAGTGGTGTGAACATTGCTGGCGTCCCTCTGAAGGATCTGAACCCAGATATAGGAACTGATAAAGATCCTGAGCAGTGGGAAAATGTCCACAAAAAAGTGATTTCCAGTGGCTATGAGATGGTCAAAATGAAAGGTTATACTTCTTGGGGCATTAGCCTATCTGTAGCTGATTTAACAGAAAGTATTTTGAAGAATCTTAGGAGAGTGCATCCAGTTTCTACCCTAAGTAAGGGCCTCTATGGAATAAATGAAGACATATTCCTTAGTGTCCCATGTATCCTGGGAGAGAATGGTATCACAGACCTCATAAAAGTAAAACTGACTCTTGAAGAGGAGGCCTGCTTGCAAAAGAGTGCAGAAACACTTTGGGAAATTCAGAAGGAGCTCAAGCTTTAAAGTTGCTTAAAGCTAATTCTGTAGATTGAAGATGAAATAGTAGTTATGGAATTGTATATGTCAAACTTTTGAATAAATTTGAATTTCTAAAAGTTGGAAAAATAGAGGAAAGAGTGACCTATTTAGTATAGCCTTCCAGCttttttttttttcttttttgggagggtctcattctgtcacccaggctggagtgcagtggcacaatcatggctcactgcaaccttgacctcccgagctcaggtgagcctcccacttcagcctccagagtaggtgggaccacatgcgtgtgcctccatgcctgcctaatttttgtatctttttgtagagatggggttttgccatgtcatccaagctggttttgaactcccaaagtgctgagattacaggggtgagccactgtgcctggccTTAGCTTTGATTTAGTATCCAGATGATAGATGACACttttttttttttttttttAAAGTGACGGCATCAAAGATGTTTTTGGTACTTCTCAGTACTTGCCTTGTATGTATACGTAATTGCCATCTGGTCCACAAGAATGTGTTTACTGTGTTACACAAATCCTGATTCTTTTCATCAGGTGCATAGTAATTCTTCTCTATGGCTTAATACCTATGTTCATTTACATGCTATCTCTACAATGTAAAAATAAAAGTGTATATATATACACACACACACAGAGAGTAATCTAAATGTTCCTAACACTAGATAAAACATTGATTTGA

Publications

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