RCPedia: Rtcs

Summary

Retrocopy Name	Spin1P4	Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species	Rattus norvegicus
Coordinates	chrX:17963190-17963575 UCSC
Strand	-
Parental Sequence	NM_001024796.1
Parental seq. overlap	316 bp
Parental seq. overlap (%)	28.7%
Genomic Region	Intergenic
Retrocopy Summary	Spin1P4, located on chrX:17963190-17963575, is a retrocopy of the parental gene Spin1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	Spin1
Full Name	spindlin 1
Also known as	Spin
Coordinate	chr16:884854-930527
Strand	-
Gene summary	Predicted to enable methylated histone binding activity. Predicted to be involved in positive regulation of Wnt signaling pathway; positive regulation of transcription, DNA-templated; and rRNA transcription. Predicted to be located in nuclear membrane; nucleolus; and spindle. Predicted to be active in cytosol and nucleoplasm. Orthologous to human SPIN1 (spindlin 1). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species	Scientific Name	Retrocopy
Gibbon	Nomascus leucogenys	SPIN1P1
Golden snub-nosed monkey	Rhinopithecus roxellana	SPIN1P1
Mouse	Mus musculus	Spin1P3
Chinese hamster	Cricetulus griseus	Spin1_1P1
Sheep	Ovis aries	SPIN1P3
Dolphin	Tursiops truncatus	SPIN1P3
Cat	Felis catus	SPIN1P1
Pale spear-nosed bat	Phyllostomus discolor	SPIN1P1
Velvety free-tailed bat	Molossus molossus	SPIN1P2
Greater horseshoe bat	Rhinolophus ferrumequinum	SPIN1P2
Sloth	Choloepus didactylus	SPIN1P5
Human	Homo sapiens	Without Homology
Chimpanzee	Pan troglodytes	Without Homology
Bonobo	Pan paniscus	Without Homology
Gorilla	Gorilla gorilla	Without Homology
Orangutan	Pongo abelii	Without Homology
Green monkey	Chlorocebus sabaeus	Without Homology
Crab-eating macaque	Macaca fascicularis	Without Homology
Rhesus	Macaca mulatta	Without Homology
Baboon	Papio anubis	Without Homology
Marmoset	Callithrix jacchus	Without Homology
Mouse lemur	Microcebus murinus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>Spin1P4
ATTGGGAAAGCAGTGGAACACATGTTTGAGGGTGAGCATGGCTCTAAGGATGAATGGAGGGGGATGGTCCTGGCCCAAGCGCCTATCATGAACGCCTGGTTTTATATTACTTATGAGAAAGATCCGGTATTGTACATGTATCAGCTTCTGGATGATTATAAAGAGGGTGACCTCCGTATCATGCCAGAGTCCAGTGCATCTCCTCCAGCAGACAGGGAGCCAGAAGGAGTTGTAGATGGCCTGATAGGTAAACATGTGGAATATACCAAAGAAGATGGCTCCAAGAGGACAGGCAAGGTCATTCACCAAGTTAAAGCCAAGCCCTCTGTGTACTTCATCAAGTTTGACGATGATTTCCATATCTATGTCTATGACTTGGTGAAAAA

>NM_001024796.1
CTTGGGTTTGCCTCCCTGAATGCGCCGGATAGATGTGCGGTGCGGATACTGCGTAGCGCCGGGGGTCGCGGTCCCTAGCGGCTTCCTGCACGGATGAGTGCTTGGGATTCCATGTGTTTTTGCTGAACTTGTAAAGGCGACACCTGGATGGTGGATTAACAAGAACACTGACCTGTGGGCAGCCTCAGCTGAGAACATTGGATTTTTCACCCTAGTCCAGCAGCTCTGCTGCTCACATAGATGCAGATGAATGAAGACCCCATTCGGGAAGACACCTGGCCAGCGGTCCAGAGCTGATGCAGGCCATGCTGGAGTCTCTGCAAACATGATGAAGAAGAGGACATCTCACAAAAAACATCGGACCAGTGTGGGACCAAGCAAACCTGTGTCCCAGCCCCGGCGGAACATCGTAGGCTGCAGGATCCAGCATGGGTGGAGAGAGGGCAACGGCCCTGTCACCCAGTGGAAGGGGACTGTCCTGGACCAGGTGCCTGTGAACCCTTCCCTGTATCTCATAAAGTACGATGGATTTGACTGTGTCTATGGACTAGAGCTGAACAAGGATGACAGAGTCTCTGCACTTGAAGTCCTCCCTGACAGAGTTGCAACATCTCGGATTAGCGATGCACACTTAGCGGACACAATGATTGGCAAAGCGGTGGAGCACATGTTTGAAACAGAGGATGGCTCTAAAGATGAGTGGAGGGGGATGGTCTTGGCACGGGCACCAGTCATGAACACATGGTTTTACATCACCTATGAGAAAGACCCTGTCTTGTACATGTACCAGCTCCTAGATGATTACAAAGAAGGCGACCTCCGCATTATGCCCGATTCCAATGATTCGCCTCCAGCAGAAAGGGAGCCAGGAGAAGTTGTGGACAGCCTGGTAGGCAAGCAAGTGGAATATGCCAAAGAAGACGGCTCGAAAAGGACTGGCATGGTCATCCATCAAGTAGAGGCCAAGCCCTCTGTCTATTTCATCAAGTTTGATGACGACTTCCATATTTACGTCTACGATTTGGTGAAAACATCCTAGATGTCATCACAAACTCTGCCAAATTTGTGGAACTATTAAATGTATAATTTGTAGACATAAA

>NM_001024796.1 

CTTGGGTTTGCCTCCCTGAATGCGCCGGATAGATGTGCGGTGCGGATACTGCGTAGCGCCGGGGGTCGCGGTCCCTAGCGGCTTCCTGCACGGATGAGTGCTTGGGATTCCATGTGTTTTTGCTGAACTTGTAAAGGCGACACCTGGATGGTGGATTAACAAGAACACTGACCTGTGGGCAGCCTCAGCTGAGAACATTGGATTTTTCACCCTAGTCCAGCAGCTCTGCTGCTCACATAGATGCAGATGAATGAAGACCCCATTCGGGAAGACACCTGGCCAGCGGTCCAGAGCTGATGCAGGCCATGCTGGAGTCTCTGCAAACATGATGAAGAAGAGGACATCTCACAAAAAACATCGGACCAGTGTGGGACCAAGCAAACCTGTGTCCCAGCCCCGGCGGAACATCGTAGGCTGCAGGATCCAGCATGGGTGGAGAGAGGGCAACGGCCCTGTCACCCAGTGGAAGGGGACTGTCCTGGACCAGGTGCCTGTGAACCCTTCCCTGTATCTCATAAAGTACGATGGATTTGACTGTGTCTATGGACTAGAGCTGAACAAGGATGACAGAGTCTCTGCACTTGAAGTCCTCCCTGACAGAGTTGCAACATCTCGGATTAGCGATGCACACTTAGCGGACACAATGATTGGCAAAGCGGTGGAGCACATGTTTGAAACAGAGGATGGCTCTAAAGATGAGTGGAGGGGGATGGTCTTGGCACGGGCACCAGTCATGAACACATGGTTTTACATCACCTATGAGAAAGACCCTGTCTTGTACATGTACCAGCTCCTAGATGATTACAAAGAAGGCGACCTCCGCATTATGCCCGATTCCAATGATTCGCCTCCAGCAGAAAGGGAGCCAGGAGAAGTTGTGGACAGCCTGGTAGGCAAGCAAGTGGAATATGCCAAAGAAGACGGCTCGAAAAGGACTGGCATGGTCATCCATCAAGTAGAGGCCAAGCCCTCTGTCTATTTCATCAAGTTTGATGACGACTTCCATATTTACGTCTACGATTTGGTGAAAACATCCTAGATGTCATCACAAACTCTGCCAAATTTGTGGAACTATTAAATGTATAATTTGTAGACATAAA

Publications

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