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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TUBA3EP1
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:5393556-5394128  UCSC
Coordinates (T2T) chr10:5396941-5397513  UCSC
Coordinates (hg19) chr10:5435519-5436091  UCSC
Strand -
Parental Sequence NM_207312.3
Parental seq. overlap 456 bp
Parental seq. overlap (%) 30%
Genomic Region Intragenic (TUBAL3)
Retrocopy Summary TUBA3EP1, located on chr10:5393556-5394128, is a retrocopy of the parental gene TUBA3E. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TUBA3E
Full Name tubulin alpha 3e
Also known as -
Coordinate chr2:130191745-130198439
Strand -
Gene summary Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. This gene encodes an alpha tubulin that highly conserved among species. A missense mutation in this gene has been potentially linked to microlissencephaly and global developmental delay. [provided by RefSeq, Jul 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TUBA3EP1
Bonobo Pan paniscus LOC100973193P2
Gorilla Gorilla gorilla LOC101135000P2
Orangutan Pongo abelii TUBA8P1
Gibbon Nomascus leucogenys TUBA8P1
Green monkey Chlorocebus sabaeus TUBA3EP1
Crab-eating macaque Macaca fascicularis LOC102121218P2
Rhesus Macaca mulatta TUBA3EP2
Baboon Papio anubis TUBA8P4
Golden snub-nosed monkey Rhinopithecus roxellana LOC115898194P1
Marmoset Callithrix jacchus LOC100390144P3
Pig Sus scrofa TUBA8P1
Dolphin Tursiops truncatus TUBA8P1
Horse Equus caballus LOC100072403P1
Dog Canis familiaris LOC100855995P1
Panda Ailuropoda melanoleuca TUBA8P1
Cat Felis catus TUBA8P1
Pale spear-nosed bat Phyllostomus discolor TUBA8P1
Velvety free-tailed bat Molossus molossus TUBA8P1
Kuhl's pipistrelle Pipistrellus kuhlii TUBA8P1
Greater horseshoe bat Rhinolophus ferrumequinum TUBA8P3
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TUBA3EP1
TCCATCACTGCCTCCCTCCGGTTTGAAGGGCCCTTGAATGTAGACCTAATTGAATTCCAGACCAACCTGGTACCTTATCCGAGAATACATTTCCCCATGACAGCCTTCGCCCCCATCGTCTCTGCTGACAAAGCCTACCATGAGCAGTTCTCTGTGTCAGACATCACCACTGCCTGCTTTGAGTCCTCCAACCAGCTGGTCAAGTGTGATCCTCGGCTTGGGAAGTACATGGCCTGCTGCCTACTCTATAGAGGGGATGTGGTCCCCAAGGAAGTGAATGCAGCAATCGCAGCCACGAAGTCGAGGCACTCTGTTCAGTTTGTAGATTGGTGTCCAACTGGTTTCAAGGTGGGCATCAACAATCGGCCGCCCACGGTGATGCCGGGTGGGGACCTGGCCAAAGTCCACCGGTCCATCTGCATGCTGAGCAACACCACGGCGATTGTGGAGGCCTGGGCCCGCCTGGACCACAAGTTTGACCTCATGTACGCCAAGAGAGCATTTCTGCACTGGTACCTCAGAGAAGGCATGGAAGAAGCAGAGTTCTTGGAGGCCAGGGAAGATCTGGCAGCC
>NM_207312.3
ATTGCAGTTGGGCGCTCAGCAGCTGTGGCAGCCGGTTGAGGTCTGGAAGTAGCGTTGGGCTGAAGCAGCGGAGTTCGCCATGCGCGAGTGTATCTCTATCCACGTGGGGCAGGCGGGTGTCCAGATCGGCAATGCCTGCTGGGAACTGTACTGCCTTGAACATGGAATTCAGCCCGATGGTCAAATGCCAAGTGATAAAACCATTGGTGGCGGGGACGACTCCTTCAACACGTTCTTCAGTGAGACTGGAGCTGGCAAGCACGTGCCCAGAGCAGTGTTTGTGGACCTGGAGCCCACTGTGGTCGATGAAGTGCGCACAGGGACCTACAGGCAGCTCTTCCACCCAGAGCAGCTGATCACCGGGAAGGAAGATGCAGCCAGTAATTACGCCAGGGGCCATTACACCATCGGCAAGGAGATTGTTGACCTAGTCCTGGACCGGATCCGCAAACTGGCGGATCTGTGCACAGGACTGCAGGGCTTCCTCATCTTCCACAGCTTTGGGGGCGGCACTGGCTCTGGGTTCGCATCTCTGCTCATGGAGCGGCTCTCAGTGGATTACAGCAAGAAGTCCAAGCTAGAGTTTGCCATTTACCCAGCCCCCCAGGTCTCCACAGCCGTGGTGGAGCCCTACAACTCCATCCTAACCACCCACACGACCCTGGAACATTCTGACTGTGCCTTCATGGTCGACAATGAAGCCATCTATGACATATGTCGGCGCAACCTGGACATTGAACGTCCCACGTACACCAACCTCAATCGCCTGATTGGGCAGATCGTGTCCTCCATCACGGCCTCCCTGCGATTTGATGGGGCCCTGAATGTGGACTTGACGGAATTCCAGACCAACCTCGTGCCGTACCCCCGCATCCACTTCCCCCTGGCCACCTACGCCCCAGTCATCTCAGCTGAGAAGGCCTACCACGAGCAGCTGTCTGTGGCCGAGATCACCAATGCCTGCTTCGAGCCAGCCAATCAGATGGTCAAGTGTGACCCTCGCCATGGCAAGTACATGGCCTGCTGCATGTTGTACAGGGGGGACGTGGTCCCCAAAGACGTCAATGCGGCCATCGCCACCATCAAGACCAAGCGCACTATCCAGTTTGTGGATTGGTGCCCGACTGGATTTAAGGTGGGCATTAACTACCAGCCCCCCACAGTGGTCCCCGGGGGAGACCTGGCCAAGGTGCAGCGGGCCGTGTGCATGCTGAGCAACACCACGGCCATTGCGGAGGCCTGGGCCCGCCTGGTCCATAAGTTCGATCTCATGTATGCCAAGTGGGCCTTTGTGCACTGGTACGTGGGCGAAGGCATGGAAGAGGGAGAGTTCTCTGAGGCCCGCGAGGACCTGGCAGCTCTAGAGAAGGATTGTGAAGAGGTGGGCGTGGATTCCGTGGAAGCTGAGGCTGAAGAAGGCGAAGCATACTGAGGGGAGGGTGTGGTGGGTTCTCCCCTGCCACCCCTAGGATGGCTGCTTTCAAGTTGTTTGCAATTAAAGATTCTGTATAAAACCAA

Publications

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