| Retrocopy Name | MKRN1P4 |
 |
| Species | Homo sapiens | |
| Coordinates (hg38) | chr15:23566646-23567053 UCSC | |
| Coordinates (T2T) | chr15:21301060-21301467 UCSC | |
| Coordinates (hg19) | chr15:23811793-23812200 UCSC | |
| Strand | + | |
| Parental Sequence | NM_013446.4 | |
| Parental seq. overlap | 335 bp | |
| Parental seq. overlap (%) | 10.8% | |
| Genomic Region |
Intergenic |
|
| Retrocopy Summary | MKRN1P4, located on chr15:23566646-23567053, is a retrocopy of the parental gene MKRN1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes. |
| Gene Name | MKRN1 |
| Full Name | makorin ring finger protein 1 |
| Also known as | RNF61 |
| Coordinate | chr7:140453033-140479505 |
| Strand | - |
| Gene summary | This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014] |
| >MKRN1P4 |
| CTGCATTGAAGCACACGAGAAAGATATGGAACTCTCGTTTGCTGTGCAGCGTGGTATGGACAAGGTGTGTGGCATCTGCATGGAGGTTGTCTATGAGAAGGCCAACCCCAATGACCGCCGCTTTGGCATTCTTTCCAATTGCAACCATTCCTTCTGTATTAGGTGTATCCGCAGGTGGAGAAGTGCCAGACAGTTTGAGAACAGGATCGTCAAGTCTTGCCCACAGTGCAGGGTCACCTCTGAATTGGTCATTCCCAGTGAGTTCTGGGTGGAGGAGGAGGAAGAGAAGCAGAAACTTATTCAGCAATACAAGGAGGCAATGAGCAACAAGGCCTGCAGGTATTTTGCGGAAGGCAGGGGTAACTGCCCATTTGGAGACACATGCTTTTACAAGCATGAATACCCTGA |
| >NM_013446.4 |
| GAGAGCGCTCAGATACGCGACGCGTAGCAGGCGGGGACCGAACGGGTGCCTCAGTGTCCTTCCCCTCCCCTCGCCTGGCCTCGCCGTCCTCTCCCCGCAGCCGGACCGGAACTATGTGATCCCGGAAGTTCCGGGGCCTTTGCTGTGTGGGATAAACAGTAATGGCGGAGGCTGCAACTCCCGGAACAACAGCCACAACATCAGGagcaggagcggcagcggcgacggcggcagcagcCTCCCCCACCCCGATCCCCACAGTCACCGCCCCGTCCCTgggggcgggcggagggggcggcggcagcgacggcagcggcggcggcTGGACTAAACAGGTCACCTGCAGGTATTTTATGCATGGGGTTTGTAAGGAAGGAGACAACTGTCGCTACTCGCATGACCTCTCTGACAGTCCGTATAGTGTAGTGTGCAAGTATTTTCAGCGAGGGTACTGTATTTATGGAGACCGCTGCAGATATGAACATAGCAAACCATTGAAACAGGAAGAAGCAACTGCTACAGAGCTAACTACAAAGTCATCCCTTGCTGCTTCCTCAAGTCTCTCATCGATAGTTGGACCACTTGTTGAAATGAATACAGGCGAAGCTGAGTCAAGAAATTCAAACTTTGCAACTGTAGGAGCAGGTTCAGAGGACTGGGTGAATGCTATTGAGTTTGTTCCTGGGCAACCCTACTGTGGCCGTACTGCGCCTTCCTGCACTGAAGCACCCCTGCAGGGCTCAGTGACCAAGGAAGAATCAGAGAAAGAGCAAACCGCCGTGGAGACAAAGAAGCAGCTGTGCCCCTATGCTGCAGTGGGAGAGTGCCGATACGGGGAGAACTGTGTGTATCTCCACGGAGATTCTTGTGACATGTGTGGGCTGCAGGTCCTGCATCCAATGGATGCTGCCCAGAGATCGCAGCATATCAAATCGTGCATTGAGGCCCATGAGAAGGACATGGAGCTCTCATTTGCCGTGCAGCGCAGCAAGGACATGGTGTGTGGGATCTGCATGGAGGTGGTCTATGAGAAAGCCAACCCCAGTGAGCGCCGCTTCGGGATCCTCTCCAACTGCAACCACACCTACTGTCTCAAGTGCATTCGCAAGTGGAGGAGTGCTAAGCAATTTGAGAGCAAGATCATAAAGTCCTGCCCAGAATGCCGGATCACATCTAACTTTGTCATTCCAAGTGAGTACTGGGTGGAGGAGAAAGAAGAGAAGCAGAAACTCATTCTGAAATACAAGGAGGCAATGAGCAACAAGGCGTGCAGGTATTTTGATGAAGGACGTGGGAGCTGCCCATTTGGAGGGAACTGTTTTTACAAGCATGCGTACCCTGATGGCCGTAGAGAGGAGCCACAGAGACAGAAAGTGGGAACATCAAGCAGATACCGGGCCCAACGAAGGAACCACTTCTGGGAACTCATTGAGGAAAGAGAGAACAGCAACCCCTTTGACAACGATGAAGAAGAGGTTGTCACCTTTGAGCTGGGCGAGATGTTGCTTATGCTTTTGGCTGCAGGTGGGGACGACGAACTAACAGACTCTGAAGATGAGTGGGACTTGTTTCATGATGAGCTGGAAGATTTTTATGACTTGGATCTATAGCAACCTTGCGTGGCGTGTGAACTGGTCTGCTGACCTCAGACAGCAGCTGTCCCCTGTGGTGGTGTGGCAGTGCCTGTGTTCTCTCCTAGGCAGGCCTCTCAACTCCAGGTGCTGTCCTAAGAATTTTTACCCAGGGCCTGTCTTCTCAACCCCTCACCTTTCCCTGAGGAGTGTGTTGTTTTCCCTGTTGAAAAAAGTTACAAAAATAAATCTTAAAGTTAGTTTTTTGTAACACGAATTTAACTGTCAGACAGTTAGTGTAGGTGTGTTGCGTCATCTGTTTTCAACCAGATTGCATTTATGGACTTTTCACACACTCATTTTGAGGACCCCAGGTTCAAAAGTAAAAGCAGTGGCCCTGCTTTGGGGTCCAAGAATAGGAGTGATGGGTGAAGGGACCTAAGCTGGCCAATAGCCCTCTGCCCCAGACATGGGATGTGGATCCTTGAGGTTTCTGGTGAAATCTGCACATCTGTGTTTTTATATCTGTTCCCTACCCTGTAATCCCTACCACGTGCACTTGTTCTGTGGTTTTGGTCTCTTGTTTAATTGCACACAAGTAATACTACTGGGTAACCAGAATCAGGTGTGAATGTGTTGAGATTTTTTACTGTTTTGCATGATAGGAAAATTGAGAAAGAATACGTATAAAAGATAGAGAGGCATAACATCAATGCAGAGTTGGAAGTTGGCTCCCAAGGGCTGACATGGTGTGAGTGTGTGGGTGTGTGATAAGCTTCTCATCCCTGCATAGATGCAGTATTCTTAGCCTTAGTAGAAAAACCTGGTTTAGTGGTTTAAGCCTTGTGTGGCAGATAGATCTTAAAGGGCAAAGCAGTATATTGGTAGTTGTCAATATAGCAGTGCTAGCTCTGTCTATATAAATAGAGAAATGGGGTTAGCCATAGAGGTTAAAACTACCTGGTTATCCCATATAATAACACAAACTGGGTCTTGGATACACAGTTGTATTTAATGTTTTACGATCTAGCCTTTCCAGTACAGGCACTTTCTGAGAAACCTTTGTCCTCACTTGAGGCATTTTGTTGTCGGGTTTTTGTGTTTGTTTTTGTGGGTATTTGCCTCATTCCACCCCTGAGCTTTCAGGTAGACAGACGTGATTCAAAACTCTGTTCTAAGGTGTTTATTGTAGTGGAGTAATGGGTTTGCAGTGATAAGTCATACTTTTCCACCGAAAGGGAGGGCTTGGGAATCCCTGAGATTAGCTAAAGTTAAGTTGTTGGAAGAATTCCTTGATTGGAAATTGTACCTTTGTGTTTTGTTGCTCTGTTTCCTGAAAATAACTCGGGGATGCTCCTGGTTTGTCCATCTACTGCTTTGATTCCTTGGATCCCACCCATTCTTTCACTTTAAGAAAAAACAAATAATTGTTGCAGAGGTCTCTGTATTTTGCAGCTGCCCTTTTGTAAGAAGCACTTTTCCCAAATAAAACAATTAAAAAAAAAGTTGGCTGTTCTGTGTAA |
| PMID - Link | Title |
|---|---|
| No publications available for this retrocopy | |
