Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SUMO2P25
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:78753602-78755071  UCSC
Coordinates (T2T) chr5:79235193-79236662  UCSC
Coordinates (hg19) chr5:78049425-78050894  UCSC
Strand +
Parental Sequence NM_006937.4
Parental seq. overlap 686 bp
Parental seq. overlap (%) 21.6%
Genomic Region Intragenic (LHFPL2)
Retrocopy Summary SUMO2P25, located on chr5:78753602-78755071, is a retrocopy of the parental gene SUMO2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SUMO2
Full Name small ubiquitin like modifier 2
Also known as HSMT3|SMT3B|SMT3H2|SUMO3|Smt3A
Coordinate chr17:75165586-75182959
Strand -
Gene summary This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SUMO2P6
Bonobo Pan paniscus SUMO2P7
Gorilla Gorilla gorilla SUMO2P25
Orangutan Pongo abelii SUMO2P8
Gibbon Nomascus leucogenys SUMO2P2
Green monkey Chlorocebus sabaeus SUMO2P3
Crab-eating macaque Macaca fascicularis SUMO2P10
Rhesus Macaca mulatta SUMO2P14
Baboon Papio anubis LOC100998135P10
Golden snub-nosed monkey Rhinopithecus roxellana SUMO2P3
Marmoset Callithrix jacchus SUMO2P1
Mouse lemur Microcebus murinus SUMO2P15
Horse Equus caballus SUMO2P6
Pale spear-nosed bat Phyllostomus discolor SUMO2P6
Greater horseshoe bat Rhinolophus ferrumequinum SUMO2P5
Egyptian rousette Rousettus aegyptiacus SUMO2P3
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SUMO2P25
AAAAAGCCTACGGCAGGAGTCAAGACTGAAAACAACAGTCACATGAATTTGAAGGTGGCAGGGAAGATGGTTTGTGGTACAGTTTAAAGTTAAGAGCCATATATCACTTAGTAAGCTAATGAAAGCCTATTGTGAATGACAGGATTTGCCAGTGAGGTAGAGCAGATTCTGATTTGATAGGCAGCCAATCAGTCAAACAGACACACCTGCACAGGTGCACATGGAGGATGAAGATACAATTGATGGGGTCCAGCATCAGACAGCAAGTACCTACTAAAAAGGGAGCCGGCTACGTTATTCCAGATTTCTGTTCCTACAGACCAAGAATATGTTCTCAATGAGAAAACCACGACTTCTTTCCACCACATCCTGACAACTACAGCAGTTTCTCTAGTCTTTCATTTTCCCTTTCCCTATCGCTTTATTGTAgTACCTAAAGTAACTGGTGTGTGTGCACAAGCTATCACATTTTTAAAAAGCTAAATGGCCAATGATATGTTTTGATCAACATCAGATGGCGATGGTTGGGAAAAATTAGTGGTTCTGTGAAAATGTCATTTTTCTCCATTGTGGCATGCTGATTCAGCTGTTTATATTCCAGGAAGTTATTTTGCTCTCACTGTTTAACAACAACACAAACAATGTAAACAATTCTTGCATGCCTTGTTCGGAGAATTATGTTTTTCATTAATCATTGTAAAAGCAAGGATGATCTTGCAACCTTTTTGTATGCAGCCATTATATGTAGGGCAGTCTGTCTTTAAGTAGGGATAGATCACTCTAAAAGAAATAAGTCCTAGATAGCTTTCCCTCCAAGTCA
>NM_006937.4
CTCTCCCCTCGTCCACCGCTGCCGCCTCCTTCTTCTGCCGCTCCTGGTGCTGCTTGTGTGCTCGTTTGGTGCGGACCTGGTACCTCTTTTGTGAAGCGGCAGCTGAGGAGACTCCGGCGCTCGCCATGGCCGACGAAAAGCCCAAGGAAGGAGTCAAGACTGAGAACAACGATCATATTAATTTGAAGGTGGCGGGGCAGGATGGTTCTGTGGTGCAGTTTAAGATTAAGAGGCATACACCACTTAGTAAACTAATGAAAGCCTATTGTGAACGACAGGGATTGTCAATGAGGCAGATCAGATTCCGATTTGACGGGCAACCAATCAATGAAACAGACACACCTGCACAGTTGGAAATGGAGGATGAAGATACAATTGATGTGTTCCAACAGCAGACGGGAGGTGTCTACTGAAAAGGGAACCTGCTTCTTTACTCCAGAACTCTGTTCTTTAAAGACCAAGATTACATTCTCAATTAGAAAACTGCAATTTGGTTCCACCACATCCTGACTACTACCGTATAGTTTTCTCTATTCTTTCATTTCCCCCTTCCCCATTCCTTTATTGTACATAAAGTAACTGGTATATGTGCACAAGCATATTGCATTTTTTTTTTTTTTAACTAAACAGCCAATGGTATGTTTTGATTGACATCAAGTGGAGACGGGATGGGGAAAAATACTGATTCTGTGAAAATACCCCCTTTCTCCATTAGTGGCATGCTCATTCAGCTCTTATCTTTATATTCCAGTAAGTTATTTTGCTCTCACTGTTTTaacaaaaaaaaaaaacaacaacataaaaaTCCTTGCATACCTTGTTCAATTGGAGAATTTTAATGTTTTTCATTTATCATTGTAAAACCAAGGACAATTTTATAACTTTTTTGTACGTAGCTGTTACATGTAGGGCAATCTGTCTTTAAGTAGGGATAAATTACTCTAAAACAAAAAAGAATCCTAGATAGTTTTCCCTTCAAGTCAAGCGTCTTGTTGTTTAAATAAACTTCTTGTTTAAAATGAGCTGTTTTCTTTATTCTGAGAAATATTAAATAGAAAATTGAGGCTTAGAAAAAACATAAATAGGCCTGCTTAGAAGTAACATTTCAAGAAGGAAATAAAGCTACTTGGTGTTTCTGACAGACTGATACTGATGCCAAACAAAGAATAACAGTTTTATAAATATCACCTTGTTCCAAAAGTTTCTCTAGGTCCCATGTTAATATGCAAGTATACTAGCAGAAAAATTGGGCCATAGTATCGTGGATTTCCAGGTATTTTCTGTATATTAAGTGAGGCACGGAGCATAGGGTATAGGGTAGCACATGTGGCAAGGAAAAAGTTCTGATTTTGCCTTTGTTGCTGATAAAACACTGAACCATTCTAGCCTGCACTTATCATAAGTAAATACTCCCTAACCTAAAATAAAGTTTTCGTTCCTTATTCAAGGAttttttttttgagacggagttttcctcttgttgcccaggctggagtgtagtggtgcaatttcagctcactgcaacctcagcctcctgagtagctggggggtcataggtgcatgccaccacgcccagctaattttttttctatttttagtcgagacagggttttatcacgtatgccaggctggtctcgaactcctgaccttaggtgatccacccgcctcagcctcccaaagtgcagggattacggcatgagccaccacgcctggccTATTCAAGAATATTGAGGGACAGAAAATATCTATATATATCCATCCTCAGAACCTTAAATATACAGGTCACTACAGTCTTTATTATTTTAATTTTTGTTTCTTAGGGTTTCTTTTGGTGGTGGttttttgagatggagcatcattccgtctcccaggctgtagtgcagtggcacaatcttggctcactgcaagctccgcctcccgggttcacgccattctcctgcctcagcctcccgtcttaggtctttttgaaagaggttatgcctctgttgcctagtctggagtggtgcaatggtgtgatcttggctcactgcaacctccacctccaggtcttaagagatcctccctgctcagcctcgtgagtagctagaaccgcaggtgcatgccaccacagctaattcttgtattttttatagagagtgtttcgccatattgtccaggccgggctcaaacccctgatcttaagtgatctatctgccttagcctcccaatgtgctgggtttacaggcgtgagccactatgcccagccCCtttttaattttttaaaaatgtttatttttgagatggagtttcgctcttgttgccccaactggagaccaatgacatgatctcagctcactgcaacctccgcctcccgggttcaactgattctcctccctcagcctccggaaaagctgggattacaagcatctaccatcatacctggctaattctgtatttttagtagagaaggggtttctctatgttggtcaggctggtctccacctcccgacctcaggtgatctgcctgccttggcctcccaaagtgctgagattacaggcttgagccactgtgcccggccaaatttttattatttttaaattagaggtggggtctcaccatgttgaccagtttggtctcgaacttctggcctcagtcccttgtcttggcctcccaaagtgttggggtttcaggtgttagaccccatgcccaaccACTACAGtttttgtttttgtttttgtttttttttcagacggagtcttgctctgtcgcccaggctggagtgcagtggcgcaatcttggctcacggcaagctccacctcccgggttcacgccattctcctgcctcagcctccccagtagctgggactaaaggtgcccgccaccatgcccggctaatttttttgtatttttagtagagacagggcttcaccatgttagccaggctggtctcaaactcctgacctcagttcatccacccgccttggccttccaaagtgctgggattacaggcatgatccactgcgcccggccTCACTGccattttatagatgagaaagccaagttccagaaaagttgtgaAATAGACGGTGACTATAAAACTGGGACTAGAGATAGTATCCTAATGCTTGTTGATTGTTTTTGTCCATACTGATTGTCAACCTACCAATATAATCTACCATCAAGTCA

Publications

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