Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Summary

Retrocopy Name RRAGA
Plot displaying the genomic locations of a retrocopy (in chr9) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr9:19049662-19050582  UCSC
Coordinates (T2T) chr9:19062527-19063447  UCSC
Coordinates (hg19) chr9:19049660-19050580  UCSC
Strand +
Parental Sequence NM_001354013.2
Parental seq. overlap 776 bp
Parental seq. overlap (%) 54.6%
Genomic Region Intergenic
Retrocopy Summary RRAGA, located on chr9:19049662-19050582, is a retrocopy of the parental gene RRAGB. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RRAGB
Full Name Ras related GTP binding B
Also known as RAGB|bA465E19.1
Coordinate chrX:55717747-55758774
Strand +
Gene summary Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RRAGBP1
Bonobo Pan paniscus RRAGBP1
Gorilla Gorilla gorilla RRAGBP1
Orangutan Pongo abelii RRAGBP1
Gibbon Nomascus leucogenys RRAGBP2
Green monkey Chlorocebus sabaeus RRAGBP1
Crab-eating macaque Macaca fascicularis RRAGBP2
Rhesus Macaca mulatta RRAGBP2
Baboon Papio anubis RRAGBP2
Golden snub-nosed monkey Rhinopithecus roxellana LOC104656747P2
Marmoset Callithrix jacchus RRAGBP1
Mouse lemur Microcebus murinus RRAGBP1
Rat Rattus norvegicus LOC108348096P1
Chinese hamster Cricetulus griseus Rragb_1P1
Rabbit Oryctolagus cuniculus RRAGBP1
Pig Sus scrofa RRAGBP1
Sheep Ovis aries RRAGBP1
Dolphin Tursiops truncatus LOC109547242P2
Horse Equus caballus RRAGBP1
Panda Ailuropoda melanoleuca RRAGBP1
Cat Felis catus RRAGBP1
Pale spear-nosed bat Phyllostomus discolor RRAGBP1
Velvety free-tailed bat Molossus molossus RRAGBP1
Greater mouse-eared bat Myotis myotis RRAGBP1
Kuhl's pipistrelle Pipistrellus kuhlii RRAGBP2
Greater horseshoe bat Rhinolophus ferrumequinum RRAGBP1
Egyptian rousette Rousettus aegyptiacus RRAGBP1
Sloth Choloepus didactylus RRAGBP1
Mouse Mus musculus Without Homology
Cow Bos taurus Without Homology
Dog Canis familiaris Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RRAGA
GCCAAATACAGCCATGAAGAAAAAGGTGCTGCTGATGGGGAAGAGCGGGTCGGGGAAGACCAGCATGAGGTCGATAATCTTCGCCAATTACATTGCTCGCGACACCCGGCGCCTGGGGGCCACCATTGACGTGGAACACTCCCACGTCCGATTCCTAGGGAACCTGGTGCTGAACCTGTGGGACTGTGGCGGTCAGGACACCTTCATGGAAAATTACTTCACCAGCCAGCGAGACAATATCTTCCGTAACGTGGAAGTTTTGATTTACGTGTTTGACGTGGAGAGCCGCGAACTGGAAAAGGACATGCATTATTACCAGTCGTGTCTGGAGGCCATCCTCCAGAACTCTCCTGACGCCAAAATCTTCTGCCTGGTGCACAAAATGGATCTGGTTCAGGAGGATCAGCGTGACCTGATTTTTAAAGAGCGAGAGGAAGACCTGAGGCGTCTGTCTCGCCCGCTGGAGTGTGCTTGTTTTCGAACGTCCATCTGGGATGAGACGCTCTACAAAGCCTGGTCCAGCATCGTCTACCAGCTGATTCCCAACGTTCAGCAGCTGGAGATGAACCTCAGGAATTTTGCCCAAATCATTGAGGCCGATGAAGTTCTGCTGTTCGAAAGAGCTACATTCTTGGTTATTTCCCACTACCAGTGCAAAGAGCAGCGCGACGTCCACCGGTTTGAGAAGATCAGCAACATCATCAAACAGTTCAAGCTGAGCTGCAGTAAATTGGCCGCTTCCTTCCAGAGCATGGAAGTTAGGAATTCCAACTTCGCTGCTTTCATCGACATCTTCACCTCAAATACGTACGTGATGGTGGTCATGTCAGATCCGTCGATCCCTTCTGCGGCCACTCTGATCAACATTCGCAATGCCCGGAAACACTTTGAGAAGCTGGAGAGAGTGGATGGCCCCAAGCA
>NM_001354013.2
AGATGCCCACGTGATCCTGGCCTGCAGTTGGGTGGCTGCGGTGGGTGCTACCAAATACAGCCATGAAGAAAAAGGTGCTGTTGATGGGTAAAAGTGGGTCTGGTAAGACCAGCATGAGGTCTATTATCTTTGCAAATTATATTGCCAGAGACACACGTCGCCTTGGCGCAACAATTGATGTAGAACATTCTCATGTTCGATTTCTGGGAAACCTGGTATTGAACCTGTGGGATTGTGGTGGGCAAGACACCTTCATGGAAAATTATTTCACTAGCCAACGGGACAACATCTTCCGAAATGTGGAGGTTCTGATTTATGTCTTTGATGTGGAGAGCCGCGAACTGGAAAAGGACATGCACTATTACCAATCATGCCTGGAGGCCATTCTGCAGAATTCTCCAGATGCCAAAATATTTTGCTTGGTACACAAAATGGATCTGGTACAGGAGGATCAACGGGACCTGATTTTTAAAGAGCGAGAAGAAGATTTGAGGCGTTTGTCTCGCCCATTGGAATGTTCTTGTTTCCGAACATCTATCTGGGATGAAACCCTCTATAAGGCTTGGTCCAGCATAGTTTATCAGCTGATTCCCAATGTTCAGCAGCTGGAAATGAACCTAAGGAATTTTGCTGAAATTATCGAAGCTGATGAAGTACTTCTTTTTGAGAGAGCTACTTTTCTGGTAATTTCTCACTATCAGTGTAAAGAGCAGCGTGATGCCCATAGATTTGAGAAAATAAGCAACATTATTAAGCAGTTCAAGCTGAGCTGCAGCAAGCTGGCTGCCTCTTTCCAGAGTATGGAAGTCAGGAACTCTAACTTCGCTGCTTTCATTGACATCTTTACATCCAACACTTATGTGATGGTTGTGATGTCTGATCCGTCCATTCCTTCTGCAGCTACTCTGATCAACATCCGCAATGCCAGGAAACACTTTGAAAAGCTGGAAAGAGTGGATGGACCAAAGCAGTGTCTTCTCATGCGCTAAACATTGATGAATATTGTTTCACACAAAAATTAAAAGTTTCCTAATTAATGTTGTATTCATATATGTAGGCTCTGAAATGTTGTGATGCTTATTGCTTCTGTATTTCTTCTCTACTCCCTAGTCTTAATGTTTAACCTTGAATGCTATTAACTTAAATAGCCATTGAGGAGTTAGAAGATGAATTGTTCATGAAGTCGGTGTTACATAAAAGTAGGTGATATGTAAGTTTTCTGATAACAAGGTTCTAATAGTGTTTAAATGTACTGGTAACCTGGTTCCAATAGTTGTGTTTGCCCAAGCCTTTCTCGGCATCATCTTGTATTCCTTATCAGATAGTAAGTAACCTGTAAGTTTGGAGTATTACTGTTTTCTCAGCATGCATTAAAAATATTCCTTAACTTCAATTGTAAATAAACTTTTGGTGTTAGGGA

Publications

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