| Retrocopy Name | FBLP2 |
|
| Species | Homo sapiens | |
| Coordinates (hg38) | chr5:168529948-168530448 UCSC | |
| Coordinates (T2T) | chr5:169064729-169065229 UCSC | |
| Coordinates (hg19) | chr5:167956953-167957453 UCSC | |
| Strand | + | |
| Parental Sequence | NM_001436.4_2 | |
| Parental seq. overlap | 414 bp | |
| Parental seq. overlap (%) | 36.8% | |
| Genomic Region |
Intergenic |
|
| Retrocopy Summary | FBLP2, located on chr5:168529948-168530448, is a retrocopy of the parental gene FBL. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes. |
| Gene Name | FBL |
| Full Name | fibrillarin |
| Also known as | FIB|FLRN|Nop1|RNU3IP1 |
| Coordinate | chr19:39834458-39846395 |
| Strand | - |
| Gene summary | This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008] |
| >FBLP2 |
| GTGGAACCCGTTCCGCTCTAAGCTGGCCGCGGCCATCCTGGGCGGGGTGGACCAGATCCACATCAAGCCCAAGTCCAAGGTGCTGTACCTGGGCGCCGCGTCGGGCACCACCGTCTCCCATGTCTCCGACATCATTGGCCCAGACGGCCTGGTCTACGCCGTCGAGTTCTCCCACCGCGCCGGCCGCGATCTGGTCAACGTGGCCAAGAAGCGCACCAACATCATTCCGGTCCTGGAGGACGCGCGGCACCCGCTCAAGTACCGCATGCTCATCGGGATGGTGGACGTGATCTTCGCCGACGTGGCCCAGCCGGACCAGTCCCGCATCGTGGCCCTGAACGCCCACACCTTCCTGCGCAATGGGGGCCACTTTCTCATCTCCATCAAGGCCAACTGCATCGACTCCACCGCATCCGCCGAGGCTGTGTTTGCTTCTGAGGTGAGGAAGTTGCAGCAGGAGAACTTGAAGCCTCAAGAGCAGCTGACCCTGGAGCCCTATGA |
| >NM_001436.4_2 |
| CTTTTCCACGTGCGAAAGCCCCGGACTCGTGGAGTTGTGAACGCCGCGGACTCCGGAGCCGCACAAACCAGGGCTCGCCATGAAGCCAGGATTCAGTCCCCGTGGGGGTGGCTTTGGCGGCCGAGGGGGCTTTGGTGACCGTGGTGGTCGTGGAGGCCGAGGGGGCTTTGGCGGGGGCCGAGGTCGAGGCGGAGGCTTTAGAGGTCGTGGACGAGGAGGAGGTGGAGGCGGCGGCGGCGGTGGAGGAGGAGGAAGAGGTGGTGGAGGCTTCCATTCTGGTGGCAACCGGGGTCGTGGTCGGGGAGGAAAAAGAGGAAACCAGTCGGGGAAGAATGTGATGGTGGAGCCGCATCGGCATGAGGGTGTCTTCATTTGTCGAGGAAAGGAAGATGCACTGGTCACCAAGAACCTGGTCCCTGGGGAATCAGTTTATGGAGAGAAGAGAGTCTCGATTTCGGAAGGAGATGACAAAATTGAGTACCGAGCCTGGAACCCCTTCCGCTCCAAGCTAGCAGCAGCAATCCTGGGTGGTGTGGACCAGATCCACATCAAACCGGGGGCTAAGGTTCTCTACCTCGGGGCTGCCTCGGGCACCACGGTCTCCCATGTCTCTGACATCGTTGGTCCGGATGGTCTAGTCTATGCAGTCGAGTTCTCCCACCGCTCTGGCCGTGACCTCATTAACTTGGCCAAGAAGAGGACCAACATCATTCCTGTGATCGAGGATGCTCGACACCCACACAAATACCGCATGCTCATCGCAATGGTGGATGTGATCTTTGCTGATGTGGCCCAGCCAGACCAGACCCGGATTGTGGCCCTGAATGCCCACACCTTCCTGCGTAATGGAGGACACTTTGTGATTTCCATTAAGGCCAACTGCATTGACTCCACAGCCTCAGCCGAGGCCGTGTTTGCCTCCGAAGTGAAAAAGATGCAACAGGAGAACATGAAGCCGCAGGAGCAGTTGACCCTTGAGCCATATGAAAGAGACCATGCCGTGGTCGTGGGAGTGTACAGGCCACCCCCCAAGGTGAAGAACTGAAGTTCAGCGCTGTCAGGATTGCGAGAGATGTGTGTTGATACTGTTGCACGTGTGTTTTTCTATTAAAAGACTCATCCGTC |
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